Sharon Rozovsky, Ph.D.
Professor
I got my Ph.D. from Columbia University, working on how proteins’ movement helps them make reactions go faster. For my postdoc at UC Berkeley, I studied the binding and interactions of proteins with biomembranes. In my own group, we combine these interests: how proteins utilize conformational mobility to perform their function and how they work together in large complexes. Specifically, we look at proteins that reside in the membrane and are involved in the trafficking of vesicles, communication between organelles, protein quality control, and protecting the cell against oxidants and invaders. I am also fascinated by the roles of selenium in proteins and the contributions of selenoproteins to human health.
Farid Ghelichkhani
Graduate Student
After receiving my bachelor’s degree in microbiology, I entered the University of Tehran to study microbial biotechnology. In my master period, I worked on purification and characterization of an extracellular protease from an actinomycete. This enzyme is highly active in extreme conditions such as high temperature and high alkalinity, which is useful for industrial purposes. My current project is centered around characterizing, both quantitatively and qualitatively, protein-protein interactions involved in a key protein degradation pathway in the endoplasmic reticulum, specifically those of selenoprotein S (selenos) using proteomics.
Fabio Gonzalez
Graduate Student
I obtained my bachelor’s degree in Chemistry and Pharmaceutical Chemistry in 2019 at Icesi University, in Colombia. My current interests involve structural biology of selenos protein complxes using cryo-electron microscopy.
Bio: Video
Masha Kapitonova
Graduate Student
Hi! My name is Masha (she/her/hers), and I am a third-year graduate student. Before joining the Rozovsky group I received a Specialist degree (the equivalent of a Master’s degree) in Lomonosov Moscow State University. My field of study lies in the intersection of virology, molecular biology, and biochemistry. Since my undergrad study, I have been studying the mechanisms of virus replication and how human proteins participate in these processes. In Prof. Rozovsky’s group, particularly, I am studying the role of selenos in the unfolded protein response, a cellular pathway that ensures optimal protein functionality.
Atinuke Odunsi
Graduate Student
I received my Bachelor’s and Master’s degrees in Biochemistry from the University of Ibadan, Nigeria. I enrolled in the Ph.D program at the University of Delaware in 2021 and I am interested in understanding how selenoprotein k (selenok) contribute to the immune system. At present, I utilize proteomics to identify and characterize interaction partners of selenok .
Erfan Rahmani
Graduate Student
I am Erfan. I received my master’s degree in Chemical Engineering from the University of Tehran, Iran. During my master’s, I developed pH-sensitive drug delivery systems for targeted cancer treatment and wound healing applications. Currently, as a graduate researcher in the Rozovsky group at the University of Delaware, I study the role of selenoprotein k (selenok) in the immune system, aiming to understand its impact on immune response and potential therapeutic applications.
Samiran Subedi
Graduate Student
Samiran earned his Master of Science degree from Tribhuvan University. His research focus on the study of derlins, integral components of the endoplasmic reticulum degradation pathway. Derlins are specialized in identifying membrane proteins and safeguarding them against incorrect folding or assembly.
Nora Zandi
Graduate Student
I am Nora, I hold a Bachelor’s degree in Medical Laboratory Science from Qazvin University of Medical Sciences, Iran. During my undergraduate studies, I conducted research on wound healing, focusing on targeted drug delivery to reduce drug side effects. Currently, I am pursuing a Ph.D. at the University of Delaware, having joined Dr. Rozovsky’s lab in 2023. My research focuses on the ATPase protein p97, which plays a critical role in the ER-associated degradation (ERAD) pathway for protein degradation. I am also involved in the structural study of p97, its interactions with selenos, and other adaptors.
Luke Coster
Undergraduate Researcher
I am a biochemistry major. I am interested in chemistry, history, cooking, and of course, cleaning glassware. I work with Fabio to identify protein partners of selenoprotein S.
Vincent Zhang
Undergraduate Researcher
Vincent is pursuing a major in Engineering and assists in the coordination and organization of the laboratory.