Discovery of Chemical Probes and Therapeutic Leads

An NIH Center of Biomedical Research Excellence


96.      Lazor, K.; Zhou, J.; DeMeester, K.; D’Ambrosio, E.; Grimes, C. L. Synthesis and application of methyl N,O-hydroxylamine muramyl peptides Chembiochem 2019. PMCID in process. 10.1002/cbic.201800731

95.      Zhang, Z.; Liu, J.; Rozovsky, S. Preparation of Selenocysteine-Containing Forms of Human SELENOK and SELENOS Methods Mol Biol 2018, 1661, 241-263. PMC6160314. 10.1007/978-1-4939-7258-6_18

94.      Xu, F.; Shuler, S. A.; Watson, D. A. Synthesis of N-H Bearing Imidazolidinones and Dihydroimidazolones Using Aza-Heck Cyclizations Angew Chem Int Ed Engl 2018, 57, 12081-12085. PMC6141047. 10.1002/anie.201806295

93.      Smith, N. J.; Rohlfing, K.; Sawicki, L. A.; Kharkar, P. M.; Boyd, S. J.; Kloxin, A. M.; Fox, J. M. Fast, irreversible modification of cysteines through strain releasing conjugate additions of cyclopropenyl ketones Org Biomol Chem 2018, 16, 2164-2169. PMC5877462. 10.1039/c8ob00166a

92.      Sawicki, L. A.; Choe, L. H.; Wiley, K. L.; Lee, K. H.; Kloxin, A. M. Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices ACS Biomater Sci Eng 2018, 4, 836-845. PMC5850091. 10.1021/acsbiomaterials.7b00647

91.      Rowland, C. A.; Lorzing, G. R.; Gosselin, E. J.; Trump, B. A.; Yap, G. P. A.; Brown, C. M.; Bloch, E. D. Methane Storage in Paddlewheel-Based Porous Coordination Cages J Am Chem Soc 2018, 140, 11153-11157. PMC6207189. 10.1021/jacs.8b05780

90.      Riley, R. S.; O’Sullivan, R. K.; Potocny, A. M.; Rosenthal, J.; Day, E. S. Evaluating Nanoshells and a Potent Biladiene Photosensitizer for Dual Photothermal and Photodynamic Therapy of Triple Negative Breast Cancer Cells Nanomaterials (Basel) 2018, 8, 658. PMC6164691. 10.3390/nano8090658

89.      Potocny, A. M.; Riley, R. S.; O’Sullivan, R. K.; Day, E. S.; Rosenthal, J. Photochemotherapeutic Properties of a Linear Tetrapyrrole Palladium(II) Complex displaying an Exceptionally High Phototoxicity Index Inorg Chem 2018, 57, 10608-10615. PMC6167929. 10.1021/acs.inorgchem.8b01225

88.      Ovadia, E. M.; Colby, D. W.; Kloxin, A. M. Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells Biomater Sci 2018, 6, 1358-1370. PMC6126667. 10.1039/c8bm00099a

87.      Moon, D. J.; Al-Amin, M.; Lewis, R. S.; Arnold, K. M.; Yap, G. P. A.; Sims-Mourtada, J.; Chain, W. J. A Strategy toward Icetexane Natural Products European J Org Chem 2018, 2018, 3348-3351. NIHMS989402, PMCID in process. 10.1002/ejoc.201800707

86.      McDonald, N. D.; DeMeester, K. E.; Lewis, A. L.; Grimes, C. L.; Boyd, E. F. Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide J Biol Chem 2018, 293, 19113-19126. PMC6295735. 10.1074/jbc.RA118.004966

85.      Macdougall, L. J.; Wiley, K. L.; Kloxin, A. M.; Dove, A. P. Design of synthetic extracellular matrices for probing breast cancer cell growth using robust cyctocompatible nucleophilic thiol-yne addition chemistry Biomaterials 2018, 178, 435-447. NIHMSID 990269, PMCID in process. 10.1016/j.biomaterials.2018.04.046

84.      Lyman, E.; Hsieh, C. L.; Eggeling, C. From Dynamics to Membrane Organization: Experimental Breakthroughs Occasion a “Modeling Manifesto” Biophys J 2018, 115, 595-604. PMC6103736. 10.1016/j.bpj.2018.07.012

83.      Liu, J.; Cheng, R.; Wu, H.; Li, S.; Wang, P. G.; DeGrado, W. F.; Rozovsky, S.; Wang, L. Building and Breaking Bonds via a Compact S-propargyl-cysteine to Chemically Control Enzymes and Modify Proteins Angewandte Chemie International Edition 2018, 57, 12702-12706. PMC6169525. doi:10.1002/anie.201806197

82.      Liu, J.; Chen, Q.; Rozovsky, S. Selenocysteine-Mediated Expressed Protein Ligation of SELENOM Methods Mol Biol 2018, 1661, 265-283. PMC5821492. 10.1007/978-1-4939-7258-6_19

81.      Liao, J.; Guan, W.; Boscoe, B. P.; Tucker, J. W.; Tomlin, J. W.; Garnsey, M. R.; Watson, M. P. Transforming Benzylic Amines into Diarylmethanes: Cross-Couplings of Benzylic Pyridinium Salts via C-N Bond Activation Org Lett 2018, 20, 3030-3033. PMC6005208. 10.1021/acs.orglett.8b01062

80.      Liang, H.; Zhou, G.; Ge, Y.; D’Ambrosio, E. A.; Eidem, T. M.; Blanchard, C.; Shehatou, C.; Chatare, V. K.; Dunman, P. M.; Valentine, A. M.; Voelz, V. A.; Grimes, C. L.; Andrade, R. B. Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus Bioorg Med Chem 2018, 26, 3453-3460. PMC6008248. 10.1016/j.bmc.2018.05.017

79.      Li, J.; Perfetto, M.; Neuner, R.; Bahudhanapati, H.; Christian, L.; Mathavan, K.; Bridges, L. C.; Alfandari, D.; Wei, S. Xenopus ADAM19 regulates Wnt signaling and neural crest specification by stabilizing ADAM13 Development 2018, 145. PMC5963864. 10.1242/dev.158154

78.      LeValley, P. J.; Ovadia, E. M.; Bresette, C. A.; Sawicki, L. A.; Maverakis, E.; Bai, S.; Kloxin, A. M. Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications Chem Commun (Camb) 2018, 54, 6923-6926. NIHMSID 988867, PMCID in process. 10.1039/c8cc03218a

77.      LeValley, P. J.; Noren, B.; Kharkar, P. M.; Kloxin, A. M.; Gatlin, J. C.; Oakey, J. S. Fabrication of Functional Biomaterial Microstructures by in Situ Photopolymerization and Photodegradation ACS Biomater Sci Eng 2018, 4, 3078-3087. NIHMSID 990268, PMCID in process. 10.1021/acsbiomaterials.8b00350

76.      Guan, W.; Liao, J.; Watson, M. P. Vinylation of Benzylic Amines via C-N Bond Functionalization of Benzylic Pyridinium Salts Synthesis (Stuttg) 2018, 50, 3231-3237. PMC6112771. 10.1055/s-0037-1610084

75.      Gosselin, E. J.; Rowland, C. A.; Balto, K. P.; Yap, G. P. A.; Bloch, E. D. Design and Synthesis of Porous Nickel(II) and Cobalt(II) Cages Inorg Chem 2018, 57, 11847-11850. PMC6207193. 10.1021/acs.inorgchem.8b01130

74.      Fang, Y.; Zhang, H.; Huang, Z.; Scinto, S. L.; Yang, J. C.; Am Ende, C. W.; Dmitrenko, O.; Johnson, D. S.; Fox, J. M. Photochemical syntheses, transformations, and bioorthogonal chemistry of trans-cycloheptene and sila trans-cycloheptene Ag(i) complexes Chem Sci 2018, 9, 1953-1963. PMC5892336. 10.1039/c7sc04773h

73.      Drolen, C.; Conklin, E.; Hetterich, S. J.; Krishnamurthy, A.; Andrade, G. A.; Dimeglio, J. L.; Martin, M. I.; Tran, L. K.; Yap, G. P. A.; Rosenthal, J.; Young, E. R. pH-Driven Mechanistic Switching from Electron Transfer to Energy Transfer between [Ru(bpy)3](2+) and Ferrocene Derivatives J Am Chem Soc 2018, 140, 10169-10178. PMC6192533. 10.1021/jacs.8b03933

72.      Drake, W. R.; Hou, C. W.; Zachara, N. E.; Grimes, C. L. New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT J Bioenerg Biomembr 2018, 50, 231-240. PMC6126917. 10.1007/s10863-018-9754-z

71.      Dicker, K. T.; Song, J.; Moore, A. C.; Zhang, H.; Li, Y.; Burris, D. L.; Jia, X.; Fox, J. M. Core-shell patterning of synthetic hydrogels via interfacial bioorthogonal chemistry for spatial control of stem cell behavior Chem Sci 2018, 9, 5394-5404. PMC6009435. 10.1039/c8sc00495a

70.      DeMeester, K. E.; Liang, H.; Jensen, M. R.; Jones, Z. S.; D’Ambrosio, E. A.; Scinto, S. L.; Zhou, J.; Grimes, C. L. Synthesis of Functionalized N-Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis J Am Chem Soc 2018, 140, 9458-9465. PMC6112571. 10.1021/jacs.8b03304

69.      Burch, J. M.; Mashayekh, S.; Wykoff, D. D.; Grimes, C. L. Bacterial Derived Carbohydrates Bind Cyr1 and Trigger Hyphal Growth in Candida albicans ACS Infect Dis 2018, 4, 53-58. PMC5800403. 10.1021/acsinfecdis.7b00154

68.      Ashkar, R.; Bilheux, H. Z.; Bordallo, H.; Briber, R.; Callaway, D. J. E.; Cheng, X.; Chu, X. Q.; Curtis, J. E.; Dadmun, M.; Fenimore, P.; Fushman, D.; Gabel, F.; Gupta, K.; Herberle, F.; Heinrich, F.; Hong, L.; Katsaras, J.; Kelman, Z.; Kharlampieva, E.; Kneller, G. R.; Kovalevsky, A.; Krueger, S.; Langan, P.; Lieberman, R.; Liu, Y.; Losche, M.; Lyman, E.; Mao, Y.; Marino, J.; Mattos, C.; Meilleur, F.; Moody, P.; Nickels, J. D.; O’Dell, W. B.; O’Neill, H.; Perez-Salas, U.; Peters, J.; Petridis, L.; Sokolov, A. P.; Stanley, C.; Wagner, N.; Weinrich, M.; Weiss, K.; Wymore, T.; Zhang, Y.; Smith, J. C. Neutron scattering in the biological sciences: progress and prospects Acta Crystallogr D Struct Biol 2018, 74, 1129-1168. PMCID in process. 10.1107/S2059798318017503

67.      Allgood, S. C.; Neunuebel, M. R. The recycling endosome and bacterial pathogens Cell Microbiol 2018, 20, e12857. PMC5993623. 10.1111/cmi.12857

66.      Wu, Z.; Zhao, S.; Fash, D. M.; Li, Z.; Chain, W. J.; Beutler, J. A. Englerins: A Comprehensive Review J Nat Prod 2017, 80, 771-781. PMC6198806. 10.1021/acs.jnatprod.6b01167

65.      Wu, B.; McDonald, A. J.; Markham, K.; Rich, C. B.; McHugh, K. P.; Tatzelt, J.; Colby, D. W.; Millhauser, G. L.; Harris, D. A. The N-terminus of the prion protein is a toxic effector regulated by the C-terminus Elife 2017, 6. PMC5469617. 10.7554/eLife.23473

64.      Wolfe, A. J.; Si, W.; Zhang, Z.; Blanden, A. R.; Hsueh, Y. C.; Gugel, J. F.; Pham, B.; Chen, M.; Loh, S. N.; Rozovsky, S.; Aksimentiev, A.; Movileanu, L. Quantification of Membrane Protein-Detergent Complex Interactions J Phys Chem B 2017, 121, 10228-10241. PMC5680101. 10.1021/acs.jpcb.7b08045

63.      Wang, Y.; Lazor, K. M.; DeMeester, K. E.; Liang, H.; Heiss, T. K.; Grimes, C. L. Postsynthetic Modification of Bacterial Peptidoglycan Using Bioorthogonal N-Acetylcysteamine Analogs and Peptidoglycan O-Acetyltransferase B J Am Chem Soc 2017, 139, 13596-13599. PMC5837961. 10.1021/jacs.7b06820

62.      Wang, P.; Killian, M. M.; Saber, M. R.; Qiu, T.; Yap, G. P. A.; Popescu, C. V.; Rosenthal, J.; Dunbar, K. R.; Brunold, T. C.; Riordan, C. G. Electronic, Magnetic, and Redox Properties and O2 Reactivity of Iron(II) and Nickel(II) o-Semiquinonate Complexes of a Tris(thioether) Ligand: Uncovering the Intradiol Cleaving Reactivity of an Iron(II) o-Semiquinonate Complex Inorg Chem 2017, 56, 10481-10495. PMC6200398. 10.1021/acs.inorgchem.7b01491

61.      Vulovic, B.; Watson, D. A. Heck-like Reactions Involving Heteroatomic Electrophiles European J Org Chem 2017, 2017, 4996-5009. PMC5665589. 10.1002/ejoc.201700485

60.      Vulovic, B.; Cinderella, A. P.; Watson, D. A. Palladium-Catalyzed Cross-Coupling of Monochlorosilanes And Grignard Reagents ACS Catal 2017, 7, 8113-8117. PMC5984048. 10.1021/acscatal.7b03465

59.      Urello, M. A.; Kiick, K. L.; Sullivan, M. O. ECM turnover-stimulated gene delivery through collagen-mimetic peptide-plasmid integration in collagen Acta Biomater 2017, 62, 167-178. PMC5654588. 10.1016/j.actbio.2017.08.038

58.      Schaefer, A. K.; Wastyk, H. C.; Mohanan, V.; Hou, C. W.; Lauro, M. L.; Melnyk, J. E.; Burch, J. M.; Grimes, C. L. Crohn’s Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70 Biochemistry 2017, 56, 4445-4448. PMC5820029. 10.1021/acs.biochem.7b00470

57.      Schaefer, A. K.; Melnyk, J. E.; Baksh, M. M.; Lazor, K. M.; Finn, M. G.; Grimes, C. L. Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2 ACS Chem Biol 2017, 12, 2216-2224. PMC5569645. 10.1021/acschembio.7b00469

56.      Rouviere, E.; Arnarez, C.; Yang, L.; Lyman, E. Identification of Two New Cholesterol Interaction Sites on the A2A Adenosine Receptor Biophys J 2017, 113, 2415-2424. PMC5738547. 10.1016/j.bpj.2017.09.027

55.      Rezazadeh, S.; Devannah, V.; Watson, D. A. Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides J Am Chem Soc 2017, 139, 8110-8113. PMC5531607. 10.1021/jacs.7b04312

54.      Rehmann, M. S.; Skeens, K. M.; Kharkar, P. M.; Ford, E. M.; Maverakis, E.; Lee, K. H.; Kloxin, A. M. Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels Biomacromolecules 2017, 18, 3131-3142. NIHMSID 990267, PMCID in process. 10.1021/acs.biomac.7b00781

53.      Liu, J.; Chen, Q.; Rozovsky, S. Utilizing Selenocysteine for Expressed Protein Ligation and Bioconjugations J Am Chem Soc 2017, 139, 3430-3437. PMC5824972. 10.1021/jacs.6b10991

52.      Liang, H.; DeMeester, K. E.; Hou, C. W.; Parent, M. A.; Caplan, J. L.; Grimes, C. L. Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications Nat Commun 2017, 8, 15015. PMC5411481. 10.1038/ncomms15015

51.      Li, J.; Qu, J.; Shi, Y.; Perfetto, M.; Ping, Z.; Christian, L.; Niu, H.; Mei, S.; Zhang, Q.; Yang, X.; Wei, S. Nicotinic acid inhibits glioma invasion by facilitating Snail1 degradation Sci Rep 2017, 7, 43173. PMC5335718. 10.1038/srep43173

50.      Lauro, M. L.; D’Ambrosio, E. A.; Bahnson, B. J.; Grimes, C. L. Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2 ACS Infect Dis 2017, 3, 264-270. PMC5820023. 10.1021/acsinfecdis.6b00154

49.      Lambert, W. D.; Scinto, S. L.; Dmitrenko, O.; Boyd, S. J.; Magboo, R.; Mehl, R. A.; Chin, J. W.; Fox, J. M.; Wallace, S. Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling Org Biomol Chem 2017, 15, 6640-6644. PMC5708333. 10.1039/c7ob01707c

48.      Krause, S. B.; McAtee, J. R.; Yap, G. P. A.; Watson, D. A. A Bench-Stable, Single-Component Precatalyst for Silyl-Heck Reactions Org Lett 2017, 19, 5641-5644. PMC5983356. 10.1021/acs.orglett.7b02807

47.      Kharkar, P. M.; Scott, R. A.; Olney, L. P.; LeValley, P. J.; Maverakis, E.; Kiick, K. L.; Kloxin, A. M. Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential Adv Healthc Mater 2017, 6. PMC5806702. 10.1002/adhm.201700713

46.      Kalburge, S. S.; Carpenter, M. R.; Rozovsky, S.; Boyd, E. F. Quorum Sensing Regulators Are Required for Metabolic Fitness in Vibrio parahaemolyticus Infect Immun 2017, 85. PMC5328491. 10.1128/iai.00930-16

45.      Guo, C.; Kim, H.; Ovadia, E. M.; Mourafetis, C. M.; Yang, M.; Chen, W.; Kloxin, A. M. Bio-orthogonal conjugation and enzymatically triggered release of proteins within multi-layered hydrogels Acta Biomater 2017, 56, 80-90. PMC5510749. 10.1016/j.actbio.2017.04.002

44.      Gietter-Burch, A. A. S.; Devannah, V.; Watson, D. A. Trifluoromethylation of Secondary Nitroalkanes Org Lett 2017, 19, 2957-2960. PMC5531277. 10.1021/acs.orglett.7b01196

43.      Drolle, E.; Bennett, W. F. D.; Hammond, K.; Lyman, E.; Karttunen, M.; Leonenko, Z. Molecular dynamics simulations and Kelvin probe force microscopy to study of cholesterol-induced electrostatic nanodomains in complex lipid mixtures Soft Matter 2017, 13, 355-362. NIHMSID 987589, PMCID in process. 10.1039/C6SM01350C

42.      Cobb, K. M.; Rabb-Lynch, J. M.; Hoerrner, M. E.; Manders, A.; Zhou, Q.; Watson, M. P. Stereospecific, Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling of Allylic Pivalates To Deliver Quaternary Stereocenters Org Lett 2017, 19, 4355-4358. PMC5576553. 10.1021/acs.orglett.7b02063

41.      Cinderella, A. P.; Vulovic, B.; Watson, D. A. Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction J Am Chem Soc 2017, 139, 7741-7744. PMC5531279. 10.1021/jacs.7b04364

40.      Basch, C. H.; Liao, J.; Xu, J.; Piane, J. J.; Watson, M. P. Harnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C-N Bond Activation J Am Chem Soc 2017, 139, 5313-5316. PMC5480296. 10.1021/jacs.7b02389

39.      Zhou, Q.; Srinivas, H. D.; Zhang, S.; Watson, M. P. Accessing Both Retention and Inversion Pathways in Stereospecific, Nickel-Catalyzed Miyaura Borylations of Allylic Pivalates J Am Chem Soc 2016, 138, 11989-11995. PMC5023504. 10.1021/jacs.6b07396

38.      Zhou, Q.; Cobb, K. M.; Tan, T.; Watson, M. P. Stereospecific Cross Couplings To Set Benzylic, All-Carbon Quaternary Stereocenters in High Enantiopurity J Am Chem Soc 2016, 138, 12057-12060. PMC5034765. 10.1021/jacs.6b08075

37.      Zhang, H.; Trout, W. S.; Liu, S.; Andrade, G. A.; Hudson, D. A.; Scinto, S. L.; Dicker, K. T.; Li, Y.; Lazouski, N.; Rosenthal, J.; Thorpe, C.; Jia, X.; Fox, J. M. Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation J Am Chem Soc 2016, 138, 5978-5983. PMC4920269. 10.1021/jacs.6b02168

36.      Zgorski, A.; Lyman, E. Toward Hydrodynamics with Solvent Free Lipid Models: STRD Martini Biophys J 2016, 111, 2689-2697. PMC5192689. 10.1016/j.bpj.2016.11.010

35.      Wang, M.; Svatunek, D.; Rohlfing, K.; Liu, Y.; Wang, H.; Giglio, B.; Yuan, H.; Wu, Z.; Li, Z.; Fox, J. Conformationally Strained trans-Cyclooctene (sTCO) Enables the Rapid Construction of (18)F-PET Probes via Tetrazine Ligation Theranostics 2016, 6, 887-895. PMC4860896. 10.7150/thno.14742

34.      Urello, M. A.; Kiick, K. L.; Sullivan, M. O. Integration of growth factor gene delivery with collagen-triggered wound repair cascades using collagen-mimetic peptides Bioeng Transl Med 2016, 1, 207-219. PMC5125401. 10.1002/btm2.10037

33.      Sodt, A. J.; Venable, R. M.; Lyman, E.; Pastor, R. W. Nonadditive Compositional Curvature Energetics of Lipid Bilayers Phys Rev Lett 2016, 117, 138104. PMC5134905. 10.1103/PhysRevLett.117.138104

32.      Shuler, S. A.; Yin, G.; Krause, S. B.; Vesper, C. M.; Watson, D. A. Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction J Am Chem Soc 2016. PMC5395365. 10.1021/jacs.6b08932

31.      Shimkin, K. W.; Gildner, P. G.; Watson, D. A. Copper-Catalyzed Alkylation of Nitroalkanes with alpha-Bromonitriles: Synthesis of beta-Cyanonitroalkanes Org Lett 2016, 18, 988-991. PMC4927086. 10.1021/acs.orglett.6b00093

30.      Sawicki, L. A.; Kloxin, A. M. Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications J Vis Exp 2016, doi: 10.3791/54462. PMC5092079. 10.3791/54462

29.      Reid, W. B.; Spillane, J. J.; Krause, S. B.; Watson, D. A. Direct Synthesis of Alkenyl Boronic Esters from Unfunctionalized Alkenes: A Boryl-Heck Reaction J Am Chem Soc 2016, 138, 5539-5542. PMC4957246. 10.1021/jacs.6b02914

28.      Rehmann, M. S.; Luna, J. I.; Maverakis, E.; Kloxin, A. M. Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiation J Biomed Mater Res A 2016, 104, 1162-1174. PMC5510610. 10.1002/jbm.a.35650

27.      Panish, R. A.; Chintala, S. R.; Fox, J. M. A Mixed-Ligand Chiral Rhodium(II) Catalyst Enables the Enantioselective Total Synthesis of Piperarborenine B Angew Chem Int Ed Engl 2016, 55, 4983-4987. PMC4900183. 10.1002/anie.201600766

26.      Nieto-Pescador, J.; Abraham, B.; Li, J.; Batarseh, A.; Bartynski, R. A.; Galoppini, E.; Gundlach, L. Heterogeneous Electron-Transfer Dynamics through Dipole-Bridge Groups J Phys Chem C Nanomater Interfaces 2016, 120, 48-55. PMC5418589. 10.1021/acs.jpcc.5b09463

25.      Mori-Quiroz, L. M.; Shimkin, K. W.; Rezazadeh, S.; Kozlowski, R. A.; Watson, D. A. Copper-Catalyzed Amidation of Primary and Secondary Alkyl Boronic Esters Chemistry 2016, 22, 15654-15658. PMC5080986. 10.1002/chem.201603677

24.      Lyman, E.; Sodt, A. J. Amphipathic Helices-Wedge? Or Nae Nae? Biophys J 2016, 110, 1-2. PMC4806210. 10.1016/j.bpj.2015.11.3513

23.      Lauro, M. L.; Burch, J. M.; Grimes, C. L. The effect of NOD2 on the microbiota in Crohn’s disease Curr Opin Biotechnol 2016, 40, 97-102. PMC5820027. 10.1016/j.copbio.2016.02.028

22.      Kharkar, P. M.; Rehmann, M. S.; Skeens, K. M.; Maverakis, E.; Kloxin, A. M. Thiol-ene click hydrogels for therapeutic delivery ACS Biomater Sci Eng 2016, 2, 165-179. PMC5369354. 10.1021/acsbiomaterials.5b00420

21.      Hou, C. W.; Mohanan, V.; Zachara, N. E.; Grimes, C. L. Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2 Glycobiology 2016, 26, 13-18. PMC4672147. 10.1093/glycob/cwv076

20.      Hilderbrand, A. M.; Ovadia, E. M.; Rehmann, M. S.; Kharkar, P. M.; Guo, C.; Kloxin, A. M. Biomaterials for 4D stem cell culture Curr Opin Solid State Mater Sci 2016, 20, 212-224. PMC5510611. 10.1016/j.cossms.2016.03.002

19.      DeAngelis, A.; Panish, R.; Fox, J. M. Rh-Catalyzed Intermolecular Reactions of alpha-Alkyl-alpha-Diazo Carbonyl Compounds with Selectivity over beta-Hydride Migration Acc Chem Res 2016, 49, 115-127. PMC4898907. 10.1021/acs.accounts.5b00425

18.      Dasgupta, S.; Liu, J.; Shoffler, C. A.; Yap, G. P.; Watson, M. P. Enantioselective, Copper-Catalyzed Alkynylation of Ketimines To Deliver Isoquinolines with alpha-Diaryl Tetrasubstituted Stereocenters Org Lett 2016, 18, 6006-6009. PMC5161116. 10.1021/acs.orglett.6b02787

17.      Basch, C. H.; Cobb, K. M.; Watson, M. P. Nickel-Catalyzed Borylation of Benzylic Ammonium Salts: Stereospecific Synthesis of Enantioenriched Benzylic Boronates Org Lett 2016, 18, 136-139. PMC4809423. 10.1021/acs.orglett.5b03455

16.      Arnarez, C.; Webb, A.; Rouviere, E.; Lyman, E. Hysteresis and the Cholesterol Dependent Phase Transition in Binary Lipid Mixtures with the Martini Model J Phys Chem B 2016, 120, 13086-13093. NIHMSID 987587, PMCID in process. 10.1021/acs.jpcb.6b09728

15.      Abraham, B.; Nieto-Pescador, J.; Gundlach, L. Ultrafast Relaxation Dynamics of Photoexcited Zinc-Porphyrin: Electronic-Vibrational Coupling J Phys Chem Lett 2016, 7, 3151-3156. PMC5424700. 10.1021/acs.jpclett.6b01439

14.      Srinivas, H. D.; Maity, P.; Yap, G. P.; Watson, M. P. Enantioselective copper-catalyzed alkynylation of benzopyranyl oxocarbenium ions J Org Chem 2015, 80, 4003-4016. PMC4822504. 10.1021/acs.joc.5b00364

13.      Sodt, A. J.; Pastor, R. W.; Lyman, E. Hexagonal Substructure and Hydrogen Bonding in Liquid-Ordered Phases Containing Palmitoyl Sphingomyelin Biophys J 2015, 109, 948-955. PMC4564825. 10.1016/j.bpj.2015.07.036

12.      Shimkin, K. W.; Watson, D. A. Recent developments in copper-catalyzed radical alkylations of electron-rich pi-systems Beilstein J Org Chem 2015, 11, 2278-2288. PMC4685898. 10.3762/bjoc.11.248

11.      Panish, R.; Selvaraj, R.; Fox, J. M. Rh(II)-Catalyzed Reactions of Diazoesters with Organozinc Reagents Org Lett 2015, 17, 3978-3981. PMC4552333. 10.1021/acs.orglett.5b01836

10.      Nieto-Pescador, J.; Abraham, B.; Pistner, A. J.; Rosenthal, J.; Gundlach, L. Electronic state dependence of heterogeneous electron transfer: injection from the S1 and S2 state of phlorin into TiO2 Phys Chem Chem Phys 2015, 17, 7914-7923. PMC4806798. 10.1039/c5cp00296f

9.         Murrey, H. E.; Judkins, J. C.; Am Ende, C. W.; Ballard, T. E.; Fang, Y.; Riccardi, K.; Di, L.; Guilmette, E. R.; Schwartz, J. W.; Fox, J. M.; Johnson, D. S. Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging J Am Chem Soc 2015, 137, 11461-11475. PMC4572613. 10.1021/jacs.5b06847

8.         Morozova, O. A.; Gupta, S.; Colby, D. W. Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation FEBS Lett 2015, 589, 1897-1903. 10.1016/j.febslet.2015.05.041

7.         Melnyk, J. E.; Mohanan, V.; Schaefer, A. K.; Hou, C. W.; Grimes, C. L. Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2 J Am Chem Soc 2015, 137, 6987-6990. PMC4878121. 10.1021/jacs.5b01607

6.         McAtee, J. R.; Krause, S. B.; Watson, D. A. Simplified Preparation of Trialkylvinylsilanes via the Silyl-Heck Reaction Utilizing a Second Generation Catalyst Adv Synth Catal 2015, 357, 2317-2321. PMC4912221. 10.1002/adsc.201500436

5.         Lyman, E. Retinal Flips the Script Biophys J 2015, 108, 2754. PMC4472061. 10.1016/j.bpj.2015.05.002

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2.         Ehle, A. R.; Morris, M. G.; Klebon, B. D.; Yap, G. P.; Watson, M. P. Stereoselective Synthesis of Trisubstituted Vinyl Bromides by Addition of Alkynes to Oxocarbenium Ions Synlett 2015, 26, 2702-2706. PMC4961304. 10.1055/s-0035-1560265

1.         Dasgupta, S.; Rivas, T.; Watson, M. P. Enantioselective Copper(I)-Catalyzed Alkynylation of Oxocarbenium Ions to Set Diaryl Tetrasubstituted Stereocenters Angew Chem Int Ed Engl 2015, 54, 14154-14158. PMC4819992. 10.1002/anie.201507373