In this NIH IDeA Center Of Biomedical Research Excellence (COBRE),  a team of scientists is developing new approaches for the discovery of molecules that can be used to study and treat a number of diseases, including breast cancer, renal cancer, Crohn’s disease, tuberculosis, and Legionnaires disease.  Using a multidisciplinary approach, this center is developing new libraries for high-throughput screening, developing chemical biology tools for studying molecular mechanisms of disease, providing perspectives on innate immune response, developing new molecules for renal cancer treatment, enabling new screening technology and advancing the state-of-the-art in virtual screening.