As of 9/2024, our center has supported 217 publications by COBRE-funded investigators, with 85 publications by other PIs who utilized COBRE core facilities.

Publications by COBRE-funded investigators

(1) Bersch, K. L.; DeMeester, K. E.; Zagani, R.; Chen, S.; Wodzanowski, K. A.; Liu, S.; Mashayekh, S.; Reinecker, H.-C.; Grimes, C. L. Bacterial Peptidoglycan Fragments Differentially Regulate Innate Immune Signaling. ACS Central Science 2021, 7, 688-696. DOI: 10.1021/acscentsci.1c00200. PMC8155477

(2) Bharadwaj, R.; Anonick, M. V.; Jaiswal, S.; Mashayekh, S.; Brown, A.; Wodzanowski, K. A.; Okuda, K.; Silverman, N.; Grimes, C. L. Synthesis and validation of click-modified NOD1/2 agonists. Innate Immunity 2023, 29, 186-200. DOI: 10.1177/17534259231207198. PMC10621468

(3) Brown, A. R.; Wodzanowski, K. A.; Santiago, C. C.; Hyland, S. N.; Follmar, J. L.; Asare-Okai, P.; Grimes, C. L. Protected N-Acetyl Muramic Acid Probes Improve Bacterial Peptidoglycan Incorporation via Metabolic Labeling. ACS Chem. Biol. 2021, 16, 1908-1916. DOI: 10.1021/acschembio.1c00268. PMC8722712

(4) Burch, J. M.; Mashayekh, S.; Wykoff, D. D.; Grimes, C. L. Bacterial Derived Carbohydrates Bind Cyr1 and Trigger Hyphal Growth in Candida albicans. ACS Infectious Diseases 2018, 4, 53-58. DOI: 10.1021/acsinfecdis.7b00154. PMC5800403

(5) Chang, P. V.; Grimes, C. L. Designer Dendrons To Dissect Innate Immune Signaling. ACS Cent Sci 2018, 4, 948-949. DOI: 10.1021/acscentsci.8b00430. PMC6107857

(6) D’Ambrosio, E. A.; Drake, W. R.; Mashayekh, S.; Ukaegbu, O. I.; Brown, A. R.; Grimes, C. L. Modulation of the NOD-like receptors NOD1 and NOD2: A chemist’s perspective. Bioorg Med Chem Lett 2019, 29, 1153-1161. DOI: 10.1016/j.bmcl.2019.03.010. PMC7679954

(7) D’Ambrosio, E. A.; Bersch, K. L.; Lauro, M. L.; Grimes, C. L. Differential Peptidoglycan Recognition Assay Using Varied Surface Presentations. J. Am. Chem. Soc. 2020, 142, 10926-10930. DOI: 10.1021/jacs.0c03933. PMC7601999

(8) DeMeester, K. E.; Liang, H.; Jensen, M. R.; Jones, Z. S.; D’Ambrosio, E. A.; Scinto, S. L.; Zhou, J.; Grimes, C. L. Synthesis of Functionalized N-Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis. J. Am. Chem. Soc.2018, 140, 9458-9465. DOI: 10.1021/jacs.8b03304. PMC6112571

(9) Drake, W. R.; Hou, C. W.; Zachara, N. E.; Grimes, C. L. New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT. Journal of Bioenergetics and Biomembranes 2018, 50, 231-240. DOI: 10.1007/s10863-018-9754-z. PMC61269817

(10) Ghosh, S.; Ahearn, C. P.; Isabella, C. R.; Marando, V. M.; Dodge, G. J.; Bartlett, H.; McPherson, R. L.; Dugan, A. E.; Jain, S.; Neznanova, L.; Tettelin, H.; Putnik, R.; Grimes, C. L.; Ruhl, S.; Kiessling, L. L.; Imperiali, B. Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host–microbe interactions with oral commensals. Proceedings of the National Academy of Sciences 2023, 120. DOI: 10.1073/pnas.2216304120. PMC10235990

(11) Hillman, A. S.; Hyland, S. N.; Wodzanowski, K. A.; Moore, D. L.; Ratna, S.; Jemas, A.; Sandles, L. D.; Chaya, T.; Ghosh, A.; Fox, J. M.; Grimes, C. L. Minimalist Tetrazine N-Acetyl Muramic Acid Probes for Rapid and Efficient Labeling of Commensal and Pathogenic Peptidoglycans in Living Bacterial Culture and During Macrophage Invasion. J. Am. Chem. Soc.2024, 146, 6817-6829. DOI: 10.1021/jacs.3c13644. PMC10941766

(12) Hou, C. W.; Mohanan, V.; Zachara, N. E.; Grimes, C. L. Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2. Glycobiology 2016, 26, 13-18. DOI: 10.1093/glycob/cwv076. PMC4672147

(13) Hyland, S. N.; Chinthamani, S.; Ratna, S.; Wodzanowski, K. A.; Sandles, L.-M. D.; Honma, K.; Leimkuhler-Grimes, C.; Sharma, A. Bioorthogonal Labeling and Click-Chemistry-Based Visualization of the Tannerella forsythia Cell Wall, PMCID book chapter. In The Bacterial Cell Wall: Methods and Protocols, Ton-That, H. Ed.; Springer US, 2024; pp 1-16.

(14) Lauro, M. L.; Burch, J. M.; Grimes, C. L. The effect of NOD2 on the microbiota in Crohn’s disease. Current Opinion in Biotechnology 2016, 40, 97-102. DOI: 10.1016/j.copbio.2016.02.028. PMC5820027

(15) Lauro, M. L.; D’Ambrosio, E. A.; Bahnson, B. J.; Grimes, C. L. Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2. ACS Infectious Diseases 2017, 3, 264-270. DOI: 10.1021/acsinfecdis.6b00154. PMC5820023

(16) Lazor, K. M.; Zhou, J.; DeMeester, K. E.; D’Ambrosio, E. A.; Grimes, C. L. Synthesis and Application of Methyl N,O-Hydroxylamine Muramyl Peptides. Chembiochem 2019, 20, 1369-1375. DOI: 10.1002/cbic.201800731. PMC6625359

(17) Liang, H.; DeMeester, K. E.; Hou, C. W.; Parent, M. A.; Caplan, J. L.; Grimes, C. L. Metabolic labelling of the carbohydrate core in bacterial peptidoglycan and its applications. Nat Commun 2017, 8, 15015. DOI: 10.1038/ncomms15015. PMC5411481

(18) Liang, H.; Zhou, G.; Ge, Y.; D’Ambrosio, E. A.; Eidem, T. M.; Blanchard, C.; Shehatou, C.; Chatare, V. K.; Dunman, P. M.; Valentine, A. M.; Voelz, V. A.; Grimes, C. L.; Andrade, R. B. Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus. Bioorganic & Medicinal Chemistry 2018, 26, 3453-3460. DOI: 10.1016/j.bmc.2018.05.017. PMC6008248

(19) Lund, V. A.; Gangotra, H.; Zhao, Z.; Sutton, J. A. F.; Wacnik, K.; DeMeester, K.; Liang, H.; Santiago, C.; Leimkuhler Grimes, C.; Jones, S.; Foster, S. J. Coupling Novel Probes with Molecular Localization Microscopy Reveals Cell Wall Homeostatic Mechanisms in Staphylococcus aureus. ACS Chem. Biol. 2022, 17, 3298-3305. DOI: 10.1021/acschembio.2c00741. PMC9764285

(20) Mashayekh, S.; Bersch, K. L.; Ramsey, J.; Harmon, T.; Prather, B.; Genova, L. A.; Grimes, C. L. Synthesis of Bacterial-Derived Peptidoglycan Cross-Linked Fragments. J. Org. Chem.2020, 85, 16243-16253. DOI: 10.1021/acs.joc.0c01852. PMC8115198

(21) McDonald, N. D.; DeMeester, K. E.; Lewis, A. L.; Grimes, C. L.; Boyd, E. F. Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide. J. Biol. Chem. 2018, 293, 19113-19126. DOI: 10.1074/jbc.RA118.004966. PMC6295735

(22) Melnyk, J. E.; Mohanan, V.; Schaefer, A. K.; Hou, C. W.; Grimes, C. L. Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2. J. Am. Chem. Soc.2015, 137, 6987-6990. DOI: 10.1021/jacs.5b01607. PMC4878121

(23) Schaefer, A. K.; Melnyk, J. E.; Baksh, M. M.; Lazor, K. M.; Finn, M. G.; Grimes, C. L. Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2. ACS Chem. Biol. 2017, 12, 2216-2224. DOI: 10.1021/acschembio.7b00469. PMC5569645

(24) Schaefer, A. K.; Wastyk, H. C.; Mohanan, V.; Hou, C. W.; Lauro, M. L.; Melnyk, J. E.; Burch, J. M.; Grimes, C. L. Crohn’s Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70. Biochemistry 2017, 56, 4445-4448. DOI: 10.1021/acs.biochem.7b00470. PMC5820029

(25) Taylor, J. A.; Bratton, B. P.; Sichel, S. R.; Blair, K. M.; Jacobs, H. M.; DeMeester, K. E.; Kuru, E.; Gray, J.; Biboy, J.; VanNieuwenhze, M. S.; Vollmer, W.; Grimes, C. L.; Shaevitz, J. W.; Salama, N. R. Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori. eLife 2020, 9, e52482. DOI: 10.7554/eLife.52482. PMC7012605

(26) Taylor, J. A.; Santiago, C. C.; Gray, J.; Wodzanowski, K. A.; DeMeester, K. E.; Biboy, J.; Vollmer, W.; Grimes, C. L.; Salama, N. R. Localizing Peptidoglycan Synthesis in Helicobacter pylori using Clickable Metabolic Probes. Current Protocols 2021, 1, e80. DOI: 10.1002/cpz1.80. PMC8118225

(27) Wang, Y.; Lazor, K. M.; DeMeester, K. E.; Liang, H.; Heiss, T. K.; Grimes, C. L. Postsynthetic Modification of Bacterial Peptidoglycan Using Bioorthogonal N-Acetylcysteamine Analogs and Peptidoglycan O-Acetyltransferase B. J. Am. Chem. Soc. 2017, 139, 13596-13599. DOI: 10.1021/jacs.7b06820. PMC5837961

(28) Wodzanowski, K. A.; Hyland, S. N.; Chinthamani, S.; Sandles, L.-M. D.; Honma, K.; Sharma, A.; Grimes, C. L. Investigating Peptidoglycan Recycling Pathways in Tannerella forsythia with N-Acetylmuramic Acid Bioorthogonal Probes. ACS Infectious Diseases 2022, 8, 1831-1838. DOI: 10.1021/acsinfecdis.2c00333. PMC9464701

(29) Kim, R. S.; Kgoadi, L. O.; Hayes, J. C.; Rainboth, D. P.; Mudd, C. M.; Yap, G. P. A.; Watson, D. A. Nickel-Catalyzed Atroposelective Cross-Electrophile Coupling of Aryl Halides: A General and Practical Route to Diverse MOP-Type Ligands. J. Am. Chem. Soc. 2024, 146, 17606-17612. DOI: 10.1021/jacs.4c04608. PMC11222061

(30) Rezazadeh, S.; Martin, M. I.; Kim, R. S.; Yap, G. P. A.; Rosenthal, J.; Watson, D. A. Photoredox-Nickel Dual-Catalyzed C-Alkylation of Secondary Nitroalkanes: Access to Sterically Hindered α-Tertiary Amines. J. Am. Chem. Soc. 2023, 145, 4707-4715. DOI: 10.1021/jacs.2c13174. PMC9992296

(31) Pawley, S. B.; Conner, A. M.; Omer, H. M.; Watson, D. A. Development of a General Method for the Hiyama–Denmark Cross-Coupling of Tetrasubstituted Vinyl Silanes. ACS Catalysis 2022, 12, 13108-13115. DOI: 10.1021/acscatal.2c03981. PMC9933925

(32) Korch, K. M.; Hayes, J. C.; Kim, R. S.; Sampson, J.; Kelly, A. T.; Watson, D. A. Selected Ion Monitoring Using Low-Cost Mass Spectrum Detectors Provides a Rapid, General, and Accurate Method for Enantiomeric Excess Determination in High-Throughput Experimentation. ACS Catalysis 2022, 12, 6737-6745. DOI: 10.1021/acscatal.2c01628. PMC9894240

(33) Zuo, Z.; Kim, R. S.; Watson, D. A. Synthesis of Axially Chiral 2,2′-Bisphosphobiarenes via a Nickel-Catalyzed Asymmetric Ullmann Coupling: General Access to Privileged Chiral Ligands without Optical Resolution. J. Am. Chem. Soc. 2021, 143, 1328-1333. DOI: 10.1021/jacs.0c12843. PMC8173523

(34) Korch, K. M.; Watson, D. A. Total Synthesis of (±)-Impatien A via Aza-Heck Cyclization. Org. Lett. 2021, 23, 7285-7289. DOI: 10.1021/acs.orglett.1c02767. PMC8454492

(35) Idowu, O. O.; Hayes, J. C.; Reid, W. B.; Watson, D. A. Synthesis of 1,1-Diboryl Alkenes Using the Boryl-Heck Reaction. Org. Lett. 2021, 23, 4838-4842. DOI: 10.1021/acs.orglett.1c01567. PMC8217338

(36) Gao, R.-D.; Shuler, S. A.; Watson, D. A. Tandem aza-Heck Suzuki and carbonylation reactions of O-phenyl hydroxamic ethers: complex lactams via carboamination. Chemical Science 2021, 12, 8859-8864. DOI: 10.1039/d1sc02075g. PMC8246078

(37) Xu, F.; Duke, O. M.; Rojas, D.; Eichelberger, H. M.; Kim, R. S.; Clark, T. B.; Watson, D. A. Arylphosphonate-Directed Ortho C–H Borylation: Rapid Entry into Highly-Substituted Phosphoarenes. J. Am. Chem. Soc. 2020, 142, 11988-11992. DOI: 10.1021/jacs.0c04159. PMC7405988

(38) Wisthoff, M. F.; Pawley, S. B.; Cinderella, A. P.; Watson, D. A. Stereoselective Synthesis of Cis- and Trans-Tetrasubstituted Vinyl Silanes Using a Silyl-Heck Strategy and Hiyama Conditions for Their Cross-Coupling. J. Am. Chem. Soc. 2020, 142, 12051-12055. DOI: 10.1021/jacs.0c05382. PMC7405989

(39) Kim, R. S.; Dinh-Nguyen, L. V.; Shimkin, K. W.; Watson, D. A. Copper-Catalyzed Propargylation of Nitroalkanes. Org. Lett. 2020, 22, 8106-8110. DOI: 10.1021/acs.orglett.0c03061. PMC7579671

(40) Xu, F.; Korch, K. M.; Watson, D. A. Synthesis of Indolines and Derivatives by Aza-Heck Cyclization. Angew. Chem. Int. Ed. 2019, 58, 13448-13451. DOI: 10.1002/anie.201907758. PMC6750995

(41) Reid, W. B.; McAtee, J. R.; Watson, D. A. Synthesis of Unsaturated Silyl Heterocycles via an Intramolecular Silyl-Heck Reaction. Organometallics 2019, 38, 3796-3803. DOI: 10.1021/acs.organomet.9b00498. PMC7236810

(42) Krause, S. B.; Watson, D. A. Silyl-Heck, Silyl-Negishi, and Related Reactions. In Organosilicon Chemistry – Novel Approaches and Reactions, Hiyama, T., Oestreich, M. Eds.; Wiley-VCH, 2019.

(43) Korch, K. M.; Watson, D. A. Cross-Coupling of Heteroatomic Electrophiles. Chemical Reviews 2019, 119, 8192-8228. DOI: 10.1021/acs.chemrev.8b00628. PMC6620169

(44) Devannah, V.; Sharma, R.; Watson, D. A. Nickel-Catalyzed Asymmetric C-Alkylation of Nitroalkanes: Synthesis of Enantioenriched β-Nitroamides. J. Am. Chem. Soc. 2019, 141, 8436-8440. DOI: 10.1021/jacs.9b04175. PMC6547819

(45) Xu, F.; Shuler, S. A.; Watson, D. A. Synthesis of N-H Bearing Imidazolidinones and Dihydroimidazolones Using Aza-Heck Cyclizations. Angew. Chem. Int. Ed. 2018, 57, 12081–12085. DOI: 10.1002/anie.201806295. PMC6141047

(46) Reid, W. B.; Watson, D. A. Synthesis of Trisubstituted Alkenyl Boronic Esters from Alkenes Using the Boryl-Heck Reaction. Org. Lett. 2018, 20, 6832-6835. DOI: 10.1021/acs.orglett.8b02949. PMC6388719

(47) Vulovic, B.; Watson, D. A. Heck-like Reactions Involving Heteroatomic Electrophiles. Eur. J. Org. Chem. 2017, 2017, 4996-5009. DOI: 10.1002/ejoc.201700485. PMC5665589

(48) Vulovic, B.; Cinderella, A. P.; Watson, D. A. Palladium-Catalyzed Cross-Coupling of Monochlorosilanes And Grignard Reagents. ACS Catal 2017, 7, 8113-8117. DOI: 10.1021/acscatal.7b03465. PMC5984048

(49) Rezazadeh, S.; Devannah, V.; Watson, D. A. Nickel-Catalyzed C-Alkylation of Nitroalkanes with Unactivated Alkyl Iodides. J. Am. Chem. Soc.2017, 139, 8110-8113. DOI: 10.1021/jacs.7b04312. PMC5531607

(50) Krause, S. B.; McAtee, J. R.; Yap, G. P. A.; Watson, D. A. A Bench-Stable, Single-Component Precatalyst for Silyl-Heck Reactions. Org. Lett. 2017, 19, 5641-5644. DOI: 10.1021/acs.orglett.7b02807. PMC5983356

(51) Gietter-Burch, A. A. S.; Devannah, V.; Watson, D. A. Trifluoromethylation of Secondary Nitroalkanes. Org. Lett. 2017, 19, 2957-2960. DOI: 10.1021/acs.orglett.7b01196. PMC5531277

(52) Cinderella, A. P.; Vulovic, B.; Watson, D. A. Palladium-Catalyzed Cross-Coupling of Silyl Electrophiles with Alkylzinc Halides: A Silyl-Negishi Reaction. J. Am. Chem. Soc.2017, 139, 7741-7744. DOI: 10.1021/jacs.7b04364. PMC5531279

(53) Shuler, S. A.; Yin, G.; Krause, S. B.; Vesper, C. M.; Watson, D. A. Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction. J. Am. Chem. Soc.2016, 138, 13830-13833. DOI: 10.1021/jacs.6b08932. PMC5395365

(54) Shimkin, K. W.; Gildner, P. G.; Watson, D. A. Copper-Catalyzed Alkylation of Nitroalkanes with alpha-Bromonitriles: Synthesis of beta-Cyanonitroalkanes. Org. Lett. 2016, 18, 988-991. DOI: 10.1021/acs.orglett.6b00093. PMC4927086

(55) Reid, W. B.; Spillane, J. J.; Krause, S. B.; Watson, D. A. Direct Synthesis of Alkenyl Boronic Esters from Unfunctionalized Alkenes: A Boryl-Heck Reaction. J. Am. Chem. Soc.2016, 138, 5539-5542. DOI: 10.1021/jacs.6b02914. PMC4957246

(56) Mori-Quiroz, L. M.; Shimkin, K. W.; Rezazadeh, S.; Kozlowski, R. A.; Watson, D. A. Copper-Catalyzed Amidation of Primary and Secondary Alkyl Boronic Esters. Chem. Eur. J. 2016, 22, 15654-15658. DOI: 10.1002/chem.201603677. PMC5080986

(57) Shimkin, K. W.; Watson, D. A. Recent developments in copper-catalyzed radical alkylations of electron-rich pi-systems. Beilstein J. Org. Chem. 2015, 11, 2278-2288. DOI: 10.3762/bjoc.11.248. PMC4685898

(58) McAtee, J. R.; Krause, S. B.; Watson, D. A. Simplified Preparation of Trialkylvinylsilanes via the Silyl-Heck Reaction Utilizing a Second Generation Catalyst. Adv. Synth. Cat. 2015, 357, 2317-2321. DOI: 10.1002/adsc.201500436. PMC4912221

(59) Gietter-Burch, A. A.; Mitrut, R. E.; Watson, D. A. Highly Diastereoselective Michael Reactions Using beta-Nitrocarbonyl Nucleophiles. Org. Lett. 2015, 17, 5468-5471. DOI: 10.1021/acs.orglett.5b02832. PMC4795467

(60) Twitty, J. C.; Hong, Y.; Garcia, B.; Tsang, S.; Liao, J.; Schultz, D. M.; Hanisak, J.; Zultanski, S. L.; Dion, A.; Kalyani, D.; Watson, M. P. Diversifying Amino Acids and Peptides via Deaminative Reductive Cross-Couplings Leveraging High-Throughput Experimentation. J. Am. Chem. Soc. 2023, 145, 5684-5695. DOI: 10.1021/jacs.2c11451. PMC10117303

(61) Gopal, M. R.; Dickey, R. M.; Butler, N. D.; Talley, M. R.; Nakamura, D. T.; Mohapatra, A.; Watson, M. P.; Chen, W.; Kunjapur, A. M. Reductive Enzyme Cascades for Valorization of Polyethylene Terephthalate Deconstruction Products. ACS Catalysis 2023, 13, 4778-4789. DOI: 10.1021/acscatal.2c06219.

(62) Garcia, B.; Sampson, J.; Watson, M. P.; Kalyani, D. Primary vs. secondary alkylpyridinium salts: a comparison under electrochemical and chemical reduction conditions. Faraday Discussions 2023, 247, 324-332. DOI: 10.1039/D3FD00120B. PMC10799965

(63) Fu, J.; Lundy, W.; Chowdhury, R.; Twitty, J. C.; Dinh, L. P.; Sampson, J.; Lam, Y.-h.; Sevov, C. S.; Watson, M. P.; Kalyani, D. Nickel-Catalyzed Electroreductive Coupling of Alkylpyridinium Salts and Aryl Halides. ACS Catalysis 2023, 13, 9336-9345. DOI: 10.1021/acscatal.3c01939. PMC10769313

(64) Baker, K. M.; Bercher, O. P.; Twitty, J. C.; Mortimer, T.; Watson, M. P. 2,6-Bis(pyrazol-1-yl)pyridine (1-bpp) as a General Ligand for the Negishi Alkylation of Alkylpyridinium Salts. J. Org. Chem.2023. DOI: 10.1021/acs.joc.3c00665.

(65) Twitty, J. C.; Hong, Y.; Garcia, B.; Tsang, S.; Liao, J.; Schultz, D.; Dion, A.; Kalyani, D.; Watson, M. Diversifying Amino Acids and Peptides via Deaminative Reductive Cross-Couplings Leveraging High-Throughput Experimentation. J. Am. Chem. Soc 2023, 145, 5684-5695. DOI: 10.1021/jacs.2c11451. PMC10117303

(66) Fu, J.; Lundy, W.; Twitty, C.; Sampson, J.; Watson, M.; Kalyani, D. Nickel-Catalyzed Electrochemical Reductive Cross-Electrophile Coupling of Alkylpyridinium Salts and Aryl Halides. ACS Catalysis 2023, 13, 9336-9345. PMC10769313

(67) Xu, J.; Twitty, J. C.; Watson, M. P. Nickel-Catalyzed Deaminative Cyanation: Nitriles and One-Carbon Homologation from Alkyl Amines. Org. Lett. 2021, 23, 6242-6245. DOI: 10.1021/acs.orglett.1c01959. PMC8653511

(68) Xu, J.; Bercher, O. P.; Watson, M. P. Overcoming the Naphthyl Requirement in Stereospecific Cross-Couplings to Form Quaternary Stereocenters. J. Am. Chem. Soc. 2021, 143, 8608-8613. DOI: 10.1021/jacs.1c03898. PMC8255275

(69) Xu, J.; Bercher, O. P.; Talley, M. R.; Watson, M. P. Nickel-Catalyzed, Stereospecific C–C and C–B Cross-Couplings via C–N and C–O Bond Activation. ACS Catalysis 2021, 11, 1604-1612. DOI: 10.1021/acscatal.0c05484. PMC8112725

(70) Bercher, O. P.; Plunkett, S.; Mortimer, T. E.; Watson, M. P. Deaminative Reductive Methylation of Alkylpyridinium Salts. Org. Lett. 2021, 23, 7059-7063. DOI: 10.1021/acs.orglett.1c02458. PMC8448964

(71) Baker, K. M.; Tallon, A.; Loach, R. P.; Bercher, O. P.; Perry, M. A.; Watson, M. P. α-Chiral Amines via Thermally Promoted Deaminative Addition of Alkylpyridinium Salts to Sulfinimines. Org. Lett. 2021, 23, 7735-7739. DOI: 10.1021/acs.orglett.1c02708. PMC8653508

(72) Wang, J.; Hoerrner, M. E.; Watson, M. P.; Weix, D. J. Nickel-Catalyzed Synthesis of Dialkyl Ketones from the Coupling of N-Alkyl Pyridinium Salts with Activated Carboxylic Acids. Angewandte Chemie International Edition 2020, 59, 13484-13489. DOI: 10.1002/anie.202002271. PMC7397811

(73) Guan, W.; Santana, S. O.; Liao, J.; Henninger, K.; Watson, M. P. Enantioselective Alkynylation of Unstabilized Cyclic Iminium Ions. ACS Catalysis 2020, 10, 13820-13824. DOI: 10.1021/acscatal.0c04223. PMC10769448

(74) Plunkett, S.; Basch, C. H.; Santana, S. O.; Watson, M. P. Harnessing Alkylpyridinium Salts as Electrophiles in Deaminative Alkyl–Alkyl Cross-Couplings. J. Am. Chem. Soc. 2019, 141, 2257-2262. DOI: 10.1021/jacs.9b00111. PMC6434706

(75) Liao, J.; Basch, C. H.; Hoerrner, M. E.; Talley, M. R.; Boscoe, B. P.; Tucker, J. W.; Garnsey, M. R.; Watson, M. P. Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides. Org. Lett. 2019, 21, 2941-2946. DOI: 10.1021/acs.orglett.9b01014. PMC6517243

(76) Hoerrner, M. E.; Baker, K. M.; Basch, C. H.; Bampo, E. M.; Watson, M. P. Deaminative Arylation of Amino Acid-derived Pyridinium Salts. Org. Lett. 2019, 21, 7356-7360. DOI: 10.1021/acs.orglett.9b02643. PMC6894616

(77) Baker, K. M.; Lucas Baca, D.; Plunkett, S.; Daneker, M. E.; Watson, M. P. Engaging Alkenes and Alkynes in Deaminative Alkyl–Alkyl and Alkyl–Vinyl Cross-Couplings of Alkylpyridinium Salts. Org. Lett. 2019, 21, 9738-9741. DOI: 10.1021/acs.orglett.9b03899. PMC6933946

(78) Pound, S. M.; Watson, M. P. Asymmetric synthesis via stereospecific C–N and C–O bond activation of alkyl amine and alcohol derivatives. Chemical Communications 2018, 54, 12286-12301. DOI: 10.1039/C8CC07093H. PMC6261259

(79) Liao, J.; Guan, W.; Boscoe, B. P.; Tucker, J. W.; Tomlin, J. W.; Garnsey, M. R.; Watson, M. P. Transforming Benzylic Amines into Diarylmethanes: Cross-Couplings of Benzylic Pyridinium Salts via C-N Bond Activation. Org. Lett. 2018, 20, 3030-3033. DOI: 10.1021/acs.orglett.8b01062. PMC6005208

(80) Guan, W.; Liao, J.; Watson, M. P. Vinylation of Benzylic Amines via C–N Bond Functionalization of Benzylic Pyridinium Salts. Synthesis 2018, 50, 3231-3237. PMC6112771

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(120) LeValley, P. J.; Ovadia, E. M.; Bresette, C. A.; Sawicki, L. A.; Maverakis, E.; Bai, S.; Kloxin, A. M. Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications. Chemical Communications 2018, 54, 6923-6926. DOI: 10.1039/C8CC03218A. PMC7433322

(121) LeValley, P. J.; Sutherland, B. P.; Jaje, J.; Gibbs, S.; Jones, R. M.; Gala, R. P.; Kloxin, C. J.; Kiick, K. L.; Kloxin, A. M. On-Demand and Tunable Dual Wavelength Release of Antibodies Using Light-Responsive Hydrogels. ACS Applied Bio Materials 2020, 3, 6944-6958. DOI: 10.1021/acsabm.0c00823. PMC8315695

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(123) Locke, R. C.; Ford, E. M.; Silbernagel, K. G.; Kloxin, A. M.; Killian, M. L. Success Criteria and Preclinical Testing of Multifunctional Hydrogels for Tendon Regeneration. Tissue Eng Part C Methods 2020, 26, 506-518. DOI: 10.1089/ten.TEC.2020.0199. PMC7869878

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(125) Macdougall, L. J.; Wiley, K. L.; Kloxin, A. M.; Dove, A. P. Design of synthetic extracellular matrices for probing breast cancer cell growth using robust cyctocompatible nucleophilic thiol-yne addition chemistry. Biomaterials 2018, 178, 435-447. DOI: 10.1016/j.biomaterials.2018.04.046. PMC6699181

(126) Ovadia, E. M.; Colby, D. W.; Kloxin, A. M. Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells. Biomaterials Science 2018, 6, 1358-1370. DOI: 10.1039/c8bm00099a. PMC6126667

(127) Palmese, L. L.; LeValley, P. J.; Pradhan, L.; Parsons, A. L.; Oakey, J. S.; Abraham, M.; D’Addio, S. M.; Kloxin, A. M.; Liang, Y.; Kiick, K. L. Injectable liposome-containing click hydrogel microparticles for release of macromolecular cargos. Soft Matter 2024, 20, 1736-1745. DOI: 10.1039/D3SM01009K. PMC10880143

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(129) Rehmann, M. S.; Skeens, K. M.; Kharkar, P. M.; Ford, E. M.; Maverakis, E.; Lee, K. H.; Kloxin, A. M. Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels. Biomacromolecules 2017, 18, 3131-3142. DOI: 10.1021/acs.biomac.7b00781. PMC6699171

(130) Sawicki, L. A.; Choe, L. H.; Wiley, K. L.; Lee, K. H.; Kloxin, A. M. Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices. ACS Biomater Sci Eng 2018, 4, 836-845. DOI: 10.1021/acsbiomaterials.7b00647. PMC5850091

(131) Sawicki, L. A.; Kloxin, A. M. Light-mediated Formation and Patterning of Hydrogels for Cell Culture Applications. Journal of visualized experiments : JoVE 2016, e54462, doi: 54410.53791/54462. DOI: 10.3791/54462. PMC5092079

(132) Sawicki, L. A.; Ovadia, E. M.; Pradhan, L.; Cowart, J. E.; Ross, K. E.; Wu, C. H.; Kloxin, A. M. Tunable synthetic extracellular matrices to investigate breast cancer response to biophysical and biochemical cues. APL Bioeng 2019, 3, 016101. DOI: 10.1063/1.5064596. PMC6481819

(133) Smith, N. J.; Rohlfing, K.; Sawicki, L. A.; Kharkar, P. M.; Boyd, S. J.; Kloxin, A. M.; Fox, J. M. Fast, irreversible modification of cysteines through strain releasing conjugate additions of cyclopropenyl ketones. Org. Biomol. Chem. 2018, 16, 2164-2169. DOI: 10.1039/c8ob00166a. PMC5877462

(134) Smithmyer, M. E.; Cassel, S. E.; Kloxin, A. M. Bridging 2D and 3D culture: probing impact of extracellular environment on fibroblast activation in layered hydrogels. AIChE J 2019, 65. DOI: 10.1002/aic.16837. PMC7480898

(135) Smithmyer, M. E.; Deng, C. C.; Cassel, S. E.; LeValley, P. J.; Sumerlin, B. S.; Kloxin, A. M. Self-Healing Boronic Acid-Based Hydrogels for 3D Co-cultures. ACS Macro Letters 2018, 7, 1105-1110. DOI: 10.1021/acsmacrolett.8b00462. PMC7437986

(136) Smithmyer, M. E.; Spohn, J. B.; Kloxin, A. M. Probing Fibroblast Activation in Response to Extracellular Cues with Whole Protein- or Peptide-Functionalized Step-Growth Hydrogels. ACS Biomaterials Science & Engineering 2018, 4, 3304-3316. DOI: 10.1021/acsbiomaterials.8b00491. PMC7269182

(137) Sutherland, B. P.; LeValley, P. J.; Bischoff, D. J.; Kloxin, A. M.; Kloxin, C. J. Sequence-defined vinyl sulfonamide click nucleic acids (VS-CNAs) and their assembly into dynamically responsive materials. Chemical Communications 2020, 56, 11263-11266. DOI: 10.1039/D0CC04235H. PMC7530108

(138) Wiley, K. L.; Ovadia, E. M.; Calo, C. J.; Huber, R. E.; Kloxin, A. M. Rate-based approach for controlling the mechanical properties of ‘thiol-ene’ hydrogels formed with visible light. Polym Chem 2019, 10, 4428-4440. DOI: 10.1039/c9py00447e. PMC7218207

(139) Amor, A. J.; Schmitz, K. R.; Baker, T. A.; Sauer, R. T. Roles of the ClpX IGF loops in ClpP association, dissociation, and protein degradation. Protein Sci 2019, 28, 756-765. DOI: 10.1002/pro.3590. PMC6423715

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(162) Thames, T.; Bryer, A. J.; Qiao, X.; Jeon, J.; Weed, R.; Janicki, K.; Hu, B.; Gor’kov, P. L.; Hung, I.; Gan, Z.; Perilla, J. R.; Chen, B. Curvature of the Retroviral Capsid Assembly Is Modulated by a Molecular Switch. The journal of physical chemistry letters 2021, 12, 7768-7776. DOI: 10.1021/acs.jpclett.1c01769. PMC9083439

(163) Xu, C.; Fischer, D. K.; Rankovic, S.; Li, W.; Dick, R. A.; Runge, B.; Zadorozhnyi, R.; Ahn, J.; Aiken, C.; Polenova, T.; Engelman, A. N.; Ambrose, Z.; Rousso, I.; Perilla, J. R. Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis. PLoS Biol 2020, 18, e3001015. DOI: 10.1371/journal.pbio.3001015. PMC7775124

(164) Xu, C.; Katyal, N.; Nesterova, T.; Perilla, J. R. Molecular determinants of Ebola nucleocapsid stability from molecular dynamics simulations. The Journal of chemical physics 2020, 153, 155102. DOI: 10.1063/5.0021491. PMC7577750

(165) Andrade, G. A.; DiMeglio, J. L.; Guardino, E. T.; Yap, G. P. A.; Rosenthal, J. Synthesis and structure of palladium(II) complexes supported by bis-NHC pincer ligands for the electrochemical activation of CO2. Polyhedron 2017, 135, 134-143. DOI: 10.1016/j.poly.2017.06.018. PMC6457682

(166) Antonio, A. M.; Rosenthal, J.; Bloch, E. D. Electrochemically Mediated Syntheses of Titanium(III)-Based Metal–Organic Frameworks. J. Am. Chem. Soc. 2019, 141, 11383-11387. DOI: 10.1021/jacs.9b05035. PMC6743718

(167) Atifi, A.; Boyce, D. W.; DiMeglio, J. L.; Rosenthal, J. Directing the Outcome of CO2 Reduction at Bismuth Cathodes Using Varied Ionic Liquid Promoters. ACS Catalysis 2018, 8, 2857-2863. DOI: 10.1021/acscatal.7b03433. PMC6457684

(168) Drolen, C.; Conklin, E.; Hetterich, S. J.; Krishnamurthy, A.; Andrade, G. A.; Dimeglio, J. L.; Martin, M. I.; Tran, L. K.; Yap, G. P. A.; Rosenthal, J.; Young, E. R. pH-Driven Mechanistic Switching from Electron Transfer to Energy Transfer between [Ru(bpy)3](2+) and Ferrocene Derivatives. J. Am. Chem. Soc.2018, 140, 10169-10178. DOI: 10.1021/jacs.8b03933. PMC6192533

(169) Kunene, T.; Xiong, L.; Rosenthal, J. Solar-powered synthesis of hydrocarbons from carbon dioxide and water. Proc. Natl. Acad. Sci. 2019, 116, 9693-9695. PMC6525484

(170) Marek, M. R. J.; Pham, T.-N.; Wang, J.; Cai, Q.; Yap, G. P. A.; Day, E. S.; Rosenthal, J. Isocorrole-Loaded Polymer Nanoparticles for Photothermal Therapy under 980 nm Light Excitation. ACS Omega 2022, 7, 36653-36662. DOI: 10.1021/acsomega.2c04723. PMC9583081

(171) Martin, M. I.; Cai, Q.; Yap, G. P. A.; Rosenthal, J. Synthesis, Redox, and Spectroscopic Properties of Pd(II) 10,10-Dimethylisocorrole Complexes Prepared via Bromination of Dimethylbiladiene Oligotetrapyrroles. Inorganic chemistry 2020, 59, 18241-18252. DOI: 10.1021/acs.inorgchem.0c02721. PMC8211382

(172) Martin, M. I.; Pham, T.-N.; Ward, K. N.; Rice, A. T.; Hertler, P. R.; Yap, G. P. A.; Gilmartin, P. H.; Rosenthal, J. Mapping the influence of ligand electronics on the spectroscopic and 1O2 sensitization characteristics of Pd(ii) biladiene complexes bearing phenyl–alkynyl groups at the 2- and 18-positions. Dalton Transactions 2023, 52, 7512-7523. DOI: 10.1039/D3DT00691C. PMC10263192

(173) Nieto-Pescador, J.; Abraham, B.; Pistner, A. J.; Rosenthal, J.; Gundlach, L. Electronic state dependence of heterogeneous electron transfer: injection from the S1 and S2 state of phlorin into TiO2. Physical chemistry chemical physics : PCCP 2015, 17, 7914-7923. DOI: 10.1039/c5cp00296f. PMC4806798

(174) Potocny, A. M.; Pistner, A. J.; Yap, G. P.; Rosenthal, J. Electrochemical, Spectroscopic and 1O2 Sensitization Characteristics of Synthetically Accessible Linear Tetrapyrrole Complexes of Palladium and Platinum. Inorganic chemistry 2017, 56, 12703–12711. PMC6192536

(175) Potocny, A. M.; Riley, R. S.; O’Sullivan, R. K.; Day, E. S.; Rosenthal, J. Photochemotherapeutic Properties of a Linear Tetrapyrrole Palladium(II) Complex displaying an Exceptionally High Phototoxicity Index. Inorganic chemistry 2018, 57, 10608–10615. DOI: 10.1021/acs.inorgchem.8b01225. PMC6167929

(176) Potocny, A. M.; Teesdale, J. J.; Marangoz, A.; Yap, G. P. A.; Rosenthal, J. Spectroscopic and 1O2 Sensitization Characteristics of a Series of Isomeric Re(bpy)(CO)3Cl Complexes Bearing Pendant BODIPY Chromophores. Inorganic chemistry 2019, 58, 5042-5050. DOI: 10.1021/acs.inorgchem.9b00102. PMC7202256

(177) Riley, R. S.; O’Sullivan, R. K.; Potocny, A. M.; Rosenthal, J.; Day, E. S. Evaluating Nanoshells and a Potent Biladiene Photosensitizer for Dual Photothermal and Photodynamic Therapy of Triple Negative Breast Cancer Cells. Nanomaterials 2018, 8, 658. PMC6164691

(178) Tcyrulnikov, S.; Cai, Q.; Twitty, J. C.; Xu, J.; Atifi, A.; Bercher, O. P.; Yap, G. P. A.; Rosenthal, J.; Watson, M. P.; Kozlowski, M. C. Dissection of Alkylpyridinium Structures to Understand Deamination Reactions. ACS Catalysis 2021, 11, 8456-8466. DOI: 10.1021/acscatal.1c01860. PMC8570559

(179) Wang, J.; Potocny, A. M.; Rosenthal, J.; Day, E. S. Gold Nanoshell-Linear Tetrapyrrole Conjugates for Near Infrared-Activated Dual Photodynamic and Photothermal Therapies. ACS Omega 2020, 5, 926-940. DOI: 10.1021/acsomega.9b04150. PMC6964518

(180) Wang, P.; Killian, M. M.; Saber, M. R.; Qiu, T.; Yap, G. P. A.; Popescu, C. V.; Rosenthal, J.; Dunbar, K. R.; Brunold, T. C.; Riordan, C. G. Electronic, Magnetic, and Redox Properties and O2 Reactivity of Iron(II) and Nickel(II) o-Semiquinonate Complexes of a Tris(thioether) Ligand: Uncovering the Intradiol Cleaving Reactivity of an Iron(II) o-Semiquinonate Complex. Inorganic chemistry 2017, 56, 10481-10495. DOI: 10.1021/acs.inorgchem.7b01491. PMC6200398

(181) Zhang, H.; Trout, W. S.; Liu, S.; Andrade, G. A.; Hudson, D. A.; Scinto, S. L.; Dicker, K. T.; Li, Y.; Lazouski, N.; Rosenthal, J.; Thorpe, C.; Jia, X.; Fox, J. M. Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation. J. Am. Chem. Soc.2016, 138, 5978-5983. DOI: 10.1021/jacs.6b02168. PMC4920269

(182) Bush, T. S.; Yap, G. P. A.; Chain, W. J. Transformation of N, N-Dimethylaniline N-Oxides into Diverse Tetrahydroquinoline Scaffolds via Formal Povarov Reactions. Org. Lett. 2018, 20, 5406-5409. DOI: 10.1021/acs.orglett.8b02318. PMC6779048

(183) Fash, D. M.; Peer, C. J.; Li, Z.; Talisman, I. J.; Hayavi, S.; Sulzmaier, F. J.; Ramos, J. W.; Sourbier, C.; Neckers, L.; Figg, W. D.; Beutler, J. A.; Chain, W. J. Synthesis of a stable and orally bioavailable englerin analogue. Bioorg Med Chem Lett 2016, 26, 2641-2644. DOI: 10.1016/j.bmcl.2016.04.016. PMC4862412

(184) Hatch, C. E.; Chain, W. J. Electrochemically Enabled Total Syntheses of Natural Products. ChemElectroChem 2023, 10. DOI: 10.1002/celc.202300140. PMC10723087

(185) Hatch, C. E.; Martin, M. I.; Gilmartin, P. H.; Xiong, L.; Beam, D. J.; Yap, G. P. A.; Von Bargen, M. J.; Rosenthal, J.; Chain, W. J. Electrochemically Mediated Oxidation of Sensitive Propargylic Benzylic Alcohols. Org. Lett. 2022, 24, 1423-1428. DOI: 10.1021/acs.orglett.1c03860. PMC9097598

(186) Lewis, R. S.; Garza, C. J.; Dang, A. T.; Pedro, T. K.; Chain, W. J. Michael Additions of Highly Basic Enolates to ortho-Quinone Methides. Org. Lett. 2015, 17, 2278-2281. DOI: 10.1021/acs.orglett.5b00972. PMC4500648

(187) Moon, D. J.; Al-Amin, M.; Lewis, R. S.; Arnold, K. M.; Yap, G. P. A.; Sims-Mourtada, J.; Chain, W. J. A Strategy toward Icetexane Natural Products. Eur. J. Org. Chem. 2018, 2018, 3348-3351. DOI: 10.1002/ejoc.201800707. PMC6433415

(188) Naeini, A. A.; Ziegelmeier, A. A.; Chain, W. J. Recent Developments with Icetexane Natural Products. Chem Biodivers 2022, 19, e202200793. DOI: 10.1002/cbdv.202200793. PMC11067433

(189) Reed, H.; Paul, T. R.; Chain, W. J. Synthesis of Halogenated Anilines by Treatment of N, N-Dialkylaniline N-Oxides with Thionyl Halides. J Org Chem 2018, 83, 11359-11368. DOI: 10.1021/acs.joc.8b01590. PMC6745195

(190) Wu, Z.; Suppo, J. S.; Tumova, S.; Strope, J.; Bravo, F.; Moy, M.; Weinstein, E. S.; Peer, C. J.; Figg, W. D.; Chain, W. J.; Echavarren, A. M.; Beech, D. J.; Beutler, J. A. Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition. ACS Med Chem Lett 2020, 11, 1711-1716. DOI: 10.1021/acsmedchemlett.0c00186. PMC7488277

(191) Wu, Z.; Zhao, S.; Fash, D. M.; Li, Z.; Chain, W. J.; Beutler, J. A. Englerins: A Comprehensive Review. J Nat Prod 2017, 80, 771-781. DOI: 10.1021/acs.jnatprod.6b01167. PMC6198806

(192) Abraham, B.; Nieto-Pescador, J.; Gundlach, L. Ultrafast Relaxation Dynamics of Photoexcited Zinc-Porphyrin: Electronic-Vibrational Coupling. The journal of physical chemistry letters 2016, 7, 3151-3156. DOI: 10.1021/acs.jpclett.6b01439. PMC5424700

(193) Nieto-Pescador, J.; Abraham, B.; Li, J.; Batarseh, A.; Bartynski, R. A.; Galoppini, E.; Gundlach, L. Heterogeneous Electron-Transfer Dynamics through Dipole-Bridge Groups. The journal of physical chemistry. C, Nanomaterials and interfaces 2016, 120, 48-55. DOI: 10.1021/acs.jpcc.5b09463. PMC5418589

(194) Gosselin, E. J.; Rowland, C. A.; Balto, K. P.; Yap, G. P. A.; Bloch, E. D. Design and Synthesis of Porous Nickel(II) and Cobalt(II) Cages. Inorganic chemistry 2018, 57, 11847-11850. DOI: 10.1021/acs.inorgchem.8b01130. PMC6207193

(195) Lorzing, G. R.; Gosselin, E. J.; Trump, B. A.; York, A. H. P.; Sturluson, A.; Rowland, C. A.; Yap, G. P. A.; Brown, C. M.; Simon, C. M.; Bloch, E. D. Understanding Gas Storage in Cuboctahedral Porous Coordination Cages. J. Am. Chem. Soc. 2019, 141, 12128-12138. DOI: 10.1021/jacs.9b05872. PMC6746114

(196) Rowland, C. A.; Lorzing, G. R.; Gosselin, E. J.; Trump, B. A.; Yap, G. P. A.; Brown, C. M.; Bloch, E. D. Methane Storage in Paddlewheel-Based Porous Coordination Cages. J. Am. Chem. Soc.2018, 140, 11153-11157. DOI: 10.1021/jacs.8b05780. PMC6207189

(197) El-Zaatari, B.; Tibbits, A. C.; Yan, Y.; Kloxin, C. J. Photoinitiated Copper(I)-Catalyzed Azide–Alkyne Cycloaddition Reaction for Ion Conductive Networks. ACS Macro Letters 2019, 8, 795-799. DOI: 10.1021/acsmacrolett.9b00324. PMC7451218

(198) El-Zaatari, B. M.; Cole, S. M.; Bischoff, D. J.; Kloxin, C. J. Copper Ligand and Anion Effects: Controlling the Kinetics of the Photoinitiated Copper(I) Catalyzed Azide-Alkyne Cycloaddition Polymerization. Polym Chem 2018, 9, 4772-4780. DOI: 10.1039/C8PY01004H. PMC6483394

(199) Kabra, M.; Kloxin, C. J. CuAAC–methacrylate interpenetrating polymer network (IPN) properties modulated by visible-light photoinitiation. Polymer Chemistry 2023, 14, 3739-3748. DOI: 10.1039/D3PY00507K. PMC10470441

(200) Ma, S. J.; Ford, E. M.; Sawicki, L. A.; Sutherland, B. P.; Halaszynski, N. I.; Carberry, B. J.; Wagner, N. J.; Kloxin, A. M.; Kloxin, C. J. Surface Chemical Functionalization of Wrinkled Thiol–Ene Elastomers for Promoting Cellular Alignment. ACS Applied Bio Materials 2020, 3, 3731-3740. DOI: 10.1021/acsabm.0c00346. PMC8315696

(201) Sutherland, B. P.; El-Zaatari, B. M.; Halaszynski, N. I.; French, J. M.; Bai, S.; Kloxin, C. J. On-Resin Macrocyclization of Peptides Using Vinyl Sulfonamides as a Thiol-Michael “Click” Acceptor. Bioconjugate Chemistry 2018, 29, 3987-3992. DOI: 10.1021/acs.bioconjchem.8b00751. PMC6467758

(202) Sutherland, B. P.; Kabra, M.; Kloxin, C. J. Expanding the thiol–X toolbox: photoinitiation and materials application of the acid-catalyzed thiol–ene (ACT) reaction. Polymer Chemistry 2021, 12, 1562-1570. DOI: 10.1039/D0PY01593H. PMC8011277

(203) Bhandari, N.; Rourke, C.; Wilmoth, T.; Bheemreddy, A.; Schulman, D.; Collins, D.; Smith, H. E.; Golden, A.; Jaramillo-Lambert, A. Identification of Suppressors of top-2 Embryonic Lethality in Caenorhabditis elegans. G3 (Bethesda) 2020, 10, 1183-1191. DOI: 10.1534/g3.119.400927. PMC7144083

(204) Warminski, M.; Trepkowska, E.; Smietanski, M.; Sikorski, P. J.; Baranowski, M. R.; Bednarczyk, M.; Kedzierska, H.; Majewski, B.; Mamot, A.; Papiernik, D.; Popielec, A.; Serwa, R. A.; Shimanski, B. A.; Sklepkiewicz, P.; Sklucka, M.; Sokolowska, O.; Spiewla, T.; Toczydlowska-Socha, D.; Warminska, Z.; Wolosewicz, K.; Zuberek, J.; Mugridge, J. S.; Nowis, D.; Golab, J.; Jemielity, J.; Kowalska, J. Trinucleotide mRNA Cap Analogue N6-Benzylated at the Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo. J. Am. Chem. Soc. 2024, 146, 8149-8163. DOI: 10.1021/jacs.3c12629. PMC10979456

(205) Bednarczyk, M.; Peters, J. K.; Kasprzyk, R.; Starek, J.; Warminski, M.; Spiewla, T.; Mugridge, J. S.; Gross, J. D.; Jemielity, J.; Kowalska, J. Fluorescence-Based Activity Screening Assay Reveals Small Molecule Inhibitors of Vaccinia Virus mRNA Decapping Enzyme D9. ACS Chem. Biol. 2022, 17, 1460-1471. DOI: 10.1021/acschembio.2c00049. PMC9207806

(206) Nguyen, D. M.; Wu, Y.; Nolin, A.; Lo, C. Y.; Guo, T.; Dhong, C.; Martin, D. C.; Kayser, L. V. Electronically Conductive Hydrogels by in Situ Polymerization of a Water-Soluble EDOT-Derived Monomer. Adv Eng Mater 2022, 24. DOI: 10.1002/adem.202200280. PMC9586015

(207) Lo, C. Y.; Wu, Y.; Awuyah, E.; Meli, D.; Nguyen, D. M.; Wu, R.; Xu, B.; Strzalka, J.; Rivnay, J.; Martin, D. C.; Kayser, L. V. Influence of the molecular weight and size distribution of PSS on mixed ionic-electronic transport in PEDOT:PSS. Polym Chem 2022, 13, 2764-2775. DOI: 10.1039/d2py00271j. PMC9523623

(208) Wu, B.; McDonald, A. J.; Markham, K.; Rich, C. B.; McHugh, K. P.; Tatzelt, J.; Colby, D. W.; Millhauser, G. L.; Harris, D. A. The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. eLife 2017, 6. DOI: 10.7554/eLife.23473. PMC5469617

(209) Morozova, O. A.; Gupta, S.; Colby, D. W. Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation. FEBS Lett 2015, 589, 1897-1903. DOI: 10.1016/j.febslet.2015.05.041.

(210) Halakos, E. G.; Connell, A. J.; Glazewski, L.; Wei, S.; Mason, R. W. Bottom up proteomics reveals novel differentiation proteins in neuroblastoma cells treated with 13-cis retinoic acid. J Proteomics 2019, 209, 103491. DOI: 10.1016/j.jprot.2019.103491. PMC7079284

(211) Halakos, E. G.; Connell, A. J.; Glazewski, L.; Wei, S.; Mason, R. W. Bottom up proteomics identifies neuronal differentiation pathway networks activated by cathepsin inhibition treatment in neuroblastoma cells that are enhanced by concurrent 13-cis retinoic acid treatment. J Proteomics 2021, 232, 104068. DOI: 10.1016/j.jprot.2020.104068. PMC7814974

(212) Li, J.; Perfetto, M.; Materna, C.; Li, R.; Thi Tran, H.; Vleminckx, K.; Duncan, M. K.; Wei, S. A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus. Sci Rep 2019, 9, 11191. DOI: 10.1038/s41598-019-47665-9. PMC6672020

(213) Li, J.; Qu, J.; Shi, Y.; Perfetto, M.; Ping, Z.; Christian, L.; Niu, H.; Mei, S.; Zhang, Q.; Yang, X.; Wei, S. Nicotinic acid inhibits glioma invasion by facilitating Snail1 degradation. Sci Rep 2017, 7, 43173. DOI: 10.1038/srep43173. PMC5335718

(214) Singh, Y.; Bird, J. G. A gel electrophoresis-based assay for measuring enzymatic RNA decapping activity. Methods Enzymol 2022, 675, 323-350. DOI: 10.1016/bs.mie.2022.07.014.

(215) Butler, N. D.; Sen, S.; Brown, L. B.; Lin, M.; Kunjapur, A. M. A platform for distributed production of synthetic nitrated proteins in live bacteria. Nat Chem Biol 2023, 19, 911-920. DOI: 10.1038/s41589-023-01338-x.

(216) Jones, M. A.; Butler, N. D.; Anderson, S. R.; Wirt, S. A.; Govil, I.; Lyu, X.; Fang, Y.; Kunjapur, A. M. Discovery of L-threonine transaldolases for enhanced biosynthesis of beta-hydroxylated amino acids. Commun Biol 2023, 6, 929. DOI: 10.1038/s42003-023-05293-0. PMC10495429

(217) Nain, P.; Dickey, R. M.; Somasundaram, V.; Sulzbach, M.; Kunjapur, A. M. Reductive amination cascades in cell-free and resting whole cell formats for valorization of lignin deconstruction products. Biotechnol Bioeng 2024, 121, 593-604. DOI: 10.1002/bit.28604. PMC10872919

Additional publications which utilized COBRE core facilities

(218) Fang, Y.; Hillman, A. S.; Fox, J. M. Advances in the Synthesis of Bioorthogonal Reagents: s-Tetrazines, 1,2,4-Triazines, Cyclooctynes, Heterocycloheptynes, and trans-Cyclooctenes. Top Curr Chem (Cham) 2024, 382, 15. DOI: 10.1007/s41061-024-00455-y. PMC38703255

(219) Dunagan, M. M.; Dabilla, N.; McNinch, C.; Brenchley, J. M.; Dolan, P. T.; Fox, J. M. Activating FcgammaRs on monocytes are necessary for optimal Mayaro virus clearance. bioRxiv 2024. DOI: 10.1101/2024.07.23.604823. PMC11326306

(220) Xu, M.; Ma, X.; Pigga, J. E.; Zhang, H.; Wang, S.; Zhao, W.; Deng, H.; Wu, A. M.; Liu, R.; Wu, Z.; Fox, J. M.; Li, Z. Development of (18)F-Labeled hydrophilic trans-cyclooctene as a bioorthogonal tool for PET probe construction. Chemical Communications 2023, 59, 14387-14390. DOI: 10.1039/d3cc04212j. PMC10785124

(221) Tallon, A. M.; Xu, Y.; West, G. M.; Am Ende, C. W.; Fox, J. M. Thiomethyltetrazines Are Reversible Covalent Cysteine Warheads Whose Dynamic Behavior can be “Switched Off” via Bioorthogonal Chemistry Inside Live Cells. J. Am. Chem. Soc.2023, 145, 16069-16080. DOI: 10.1021/jacs.3c04444. PMC10530612

(222) Rosenberger, J. E.; Xie, Y.; Fang, Y.; Lyu, X.; Trout, W. S.; Dmitrenko, O.; Fox, J. M. Ligand-Directed Photocatalysts and Far-Red Light Enable Catalytic Bioorthogonal Uncaging inside Live Cells. J. Am. Chem. Soc.2023, 145, 6067-6078. DOI: 10.1021/jacs.2c10655. PMC10589873

(223) Pol, M.; Gao, H.; Zhang, H.; George, O. J.; Fox, J. M.; Jia, X. Dynamic modulation of matrix adhesiveness induces epithelial-to-mesenchymal transition in prostate cancer cells in 3D. Biomaterials 2023, 299, 122180. DOI: 10.1016/j.biomaterials.2023.122180. PMC10330660

(224) Song, J.; Gao, H.; Zhang, H.; George, O. J.; Hillman, A. S.; Fox, J. M.; Jia, X. Matrix Adhesiveness Regulates Myofibroblast Differentiation from Vocal Fold Fibroblasts in a Bio-orthogonally Cross-linked Hydrogel. ACS Appl Mater Interfaces 2022, 14, 51669-51682. DOI: 10.1021/acsami.2c13852. PMC10350853

(225) Scinto, S. L.; Reagle, T. R.; Fox, J. M. Affinity Bioorthogonal Chemistry (ABC) Tags for Site-Selective Conjugation, On-Resin Protein-Protein Coupling, and Purification of Protein Conjugates. Angewandte Chemie International Edition 2022, 61, e202207661. DOI: 10.1002/anie.202207661. PMC10029600

(226) Jemas, A.; Xie, Y.; Pigga, J. E.; Caplan, J. L.; am Ende, C. W.; Fox, J. M. Catalytic Activation of Bioorthogonal Chemistry with Light (CABL) Enables Rapid, Spatiotemporally Controlled Labeling and No-Wash, Subcellular 3D-Patterning in Live Cells Using Long Wavelength Light. J. Am. Chem. Soc. 2022, 144, 1647-1662. DOI: 10.1021/jacs.1c10390. PMC9364228

(227) George, O. J.; Song, J.; Benson, J. M.; Fang, Y.; Zhang, H.; Burris, D. L.; Fox, J. M.; Jia, X. Tunable Synthesis of Hydrogel Microfibers via Interfacial Tetrazine Ligation. Biomacromolecules 2022, 23, 3017-3030. DOI: 10.1021/acs.biomac.2c00504. PMC10410669

(228) Wang, C.; Zhang, H.; Zhang, T.; Zou, X.; Wang, H.; Rosenberger, J. E.; Vannam, R.; Trout, W. S.; Grimm, J. B.; Lavis, L. D.; Thorpe, C.; Jia, X.; Li, Z.; Fox, J. M. Enabling In Vivo Photocatalytic Activation of Rapid Bioorthogonal Chemistry by Repurposing Silicon-Rhodamine Fluorophores as Cytocompatible Far-Red Photocatalysts. J. Am. Chem. Soc.2021, 143, 10793-10803. DOI: 10.1021/jacs.1c05547. PMC8765119

(229) Scinto, S. L.; Bilodeau, D. A.; Hincapie, R.; Lee, W.; Nguyen, S. S.; Xu, M.; Am Ende, C. W.; Finn, M. G.; Lang, K.; Lin, Q.; Pezacki, J. P.; Prescher, J. A.; Robillard, M. S.; Fox, J. M. Bioorthogonal chemistry. Nat Rev Methods Primers 2021, 1. DOI: 10.1038/s43586-021-00028-z. PMC8469592

(230) Pigga, J. E.; Rosenberger, J. E.; Jemas, A.; Boyd, S. J.; Dmitrenko, O.; Xie, Y.; Fox, J. M. General, Divergent Platform for Diastereoselective Synthesis of trans-Cyclooctenes with High Reactivity and Favorable Physiochemical Properties*. Angew. Chem. Int. Ed. 2021, 60, 14975-14980. DOI: 10.1002/anie.202101483. PMC8754160

(231) Xie, Y.; Fang, Y.; Huang, Z.; Tallon, A. M.; Am Ende, C. W.; Fox, J. M. Divergent Synthesis of Monosubstituted and Unsymmetrical 3,6-Disubstituted Tetrazines from Carboxylic Ester Precursors. Angew. Chem. Int. Ed. 2020, 59, 16967-16973. DOI: 10.1002/anie.202005569. PMC7733736

(232) Pigga, J. E.; Fox, J. M. Flow Photochemical Syntheses of trans-Cyclooctenes and trans-Cycloheptenes Driven by Metal Complexation. Isr J Chem 2020, 60, 207-218. DOI: 10.1002/ijch.201900085. PMC8186252

(233) O’Brien, J. G. K.; Jemas, A.; Asare-Okai, P. N.; Am Ende, C. W.; Fox, J. M. Probing the Mechanism of Photoaffinity Labeling by Dialkyldiazirines through Bioorthogonal Capture of Diazoalkanes. Org. Lett. 2020, 22, 9415-9420. DOI: 10.1021/acs.orglett.0c02714. PMC7802889

(234) Feng, H.; Zhang, H.; Wang, M.; Vannam, R.; Wang, H.; Yan, X.; Ouyang, W.; Jia, X.; Fox, J. M.; Li, Z. Improving Tumor-to-Background Contrast through Hydrophilic Tetrazines: The Construction of (18) F-Labeled PET Agents Targeting Nonsmall Cell Lung Carcinoma. Chemistry 2020, 26, 4690-4694. DOI: 10.1002/chem.202000028. PMC7764167

(235) Wang, M.; Vannam, R.; Lambert, W. D.; Xie, Y.; Wang, H.; Giglio, B.; Ma, X.; Wu, Z.; Fox, J.; Li, Z. Hydrophilic (18)F-labeled trans-5-oxocene (oxoTCO) for efficient construction of PET agents with improved tumor-to-background ratios in neurotensin receptor (NTR) imaging. Chem Commun 2019, 55, 2485-2488. DOI: 10.1039/c8cc09747j. PMC7347157

(236) Scinto, S. L.; Ekanayake, O.; Seneviratne, U.; Pigga, J. E.; Boyd, S. J.; Taylor, M. T.; Liu, J.; Am Ende, C. W.; Rozovsky, S.; Fox, J. M. Dual-Reactivity trans-Cyclooctenol Probes for Sulfenylation in Live Cells Enable Temporal Control via Bioorthogonal Quenching. J. Am. Chem. Soc.2019, 141, 10932-10937. DOI: 10.1021/jacs.9b01164. PMC6756850

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