Publications
Publications
JOURNAL PUBLICATIONS
Porter A, Peng Y, Santare M, Han L, Peolquin J, Lu XL. Comparison of mechanical response of temporomandibular joint and knee condylar cartilage under dynamic mechanical loading. Osteoarthritis and Cartilage 2025, Advanced online publication. https://doi.org/10.1016/j.joca.2025.09.007.
Porter A, Newcomb E, DiStefano S, Poplawski J, Kim J, Axe M, Lu XL. Triamcinolone Acetonide Has Minimal Effect on Short- and Long-Term Metabolic Activities of Cartilage. Journal of Orthopaedic Research 2024, 42 (11), 2426-2436. https://doi.org/10.1002/jor.25913.
Che VL, Zimmermann J, Zhou Y, Lu XL, Van Rienen U. Deriving Models of Cartilaginous Cells From Confocal Fluorescence Microscopy Images to Estimate Dielectric Properties. IEEE Transactions on Magnetics 2024, 60 (3), 1–4. https://doi.org/10.1109/TMAG.2023.3307009.
Che VL, Zimmermann J, Zhou Y, Lu XL, Van Rienen U. Contributions of Deep Learning to Automated Numerical Modelling of the Interaction of Electric Fields and Cartilage Tissue Based on 3D Images. Frontiers in Bioengineering and Biotechnology 2023, 11. https://doi.org/10.3389/fbioe.2023.1225495.
Li W, Zhou Y, Han L, Wang L, Lu XL. Calcium Signaling of Primary Chondrocytes and ATDC5 Chondrogenic Cells under Osmotic Stress and Mechanical Stimulation. Journal of Biomechanics 2022, 145, 111388. https://doi.org/10.1016/j.jbiomech.2022.111388.
Fan M, Wang C, Kwok B, Kahle ER, He L, Lu XL, Mauck RL, Han L. Impacts of Aging on Murine Cartilage Biomechanics and Chondrocyte in Situ Calcium Signaling. Journal of Biomechanics 2022, 144, 111336. https://doi.org/10.1016/j.jbiomech.2022.111336.
Porter A, Wang L, Han L, Lu XL. Bio-Orthogonal Click Chemistry Methods to Evaluate the Metabolism of Inflammatory Challenged Cartilage after Traumatic Overloading. ACS Biomater. Sci. Eng. 2022, 8 (6), 2564–2573. https://doi.org/10.1021/acsbiomaterials.2c00024.
Kahle ER, Han B, Chandrasekaran P, Phillips ER, Mulcahey MK, Lu XL, Marcolongo MS, Han L. Molecular Engineering of Pericellular Microniche via Biomimetic Proteoglycans Modulates Cell Mechanobiology. ACS Nano 2022, 16 (1), 1220–1230. https://doi.org/10.1021/acsnano.1c09015.
Pei S, Wang S, Martinez JR, Parajuli A, Kirn-Safran CB, Farach-Carson MC, Lu XL, Wang L. Osteocytic Pericellular Matrix (PCM): Accelerated Degradation under In Vivo Loading and Unloading Conditions Using a Novel Imaging Approach. Genes 2022, 13 (1), 72. https://doi.org/10.3390/genes13010072.
Chandrasekaran P, Kwok B, Han B, Adams SM, Wang C, Chery DR, Mauck RL, Dyment NA, Lu XL, Frank DB, Koyama E, Birk DE, Han L. Type V Collagen Regulates the Structure and Biomechanics of TMJ Condylar Cartilage: A Fibrous-Hyaline Hybrid. Matrix Biology 2021, 102, 1–19. https://doi.org/10.1016/j.matbio.2021.07.002.
Chery DR, Han B, Zhou Y, Wang C, Adams SM, Chandrasekaran P, Kwok B, Heo SJ, Enomoto-Iwamoto M, Lu XL, Kong D, Iozzo RV, Birk DE, Mauck RL, Han L. Decorin Regulates Cartilage Pericellular Matrix Micromechanobiology. Matrix Biology 2021, 96, 1–17. https://doi.org/10.1016/j.matbio.2020.11.002.
Chery DR, Han B, Li Q, Zhou Y, Heo SJ, Kwok B, Chandrasekaran P, Wang C, Qin L, Lu XL, Kong D, Enomoto-Iwamoto M, Mauck RL, Han L. Early Changes in Cartilage Pericellular Matrix Micromechanobiology Portend the Onset of Post-Traumatic Osteoarthritis. Acta Biomaterialia 2020, 111, 267–278. https://doi.org/10.1016/j.actbio.2020.05.005.
Wang Q, Pei S, Lu XL, Wang L, Wu Q. On the Characterization of Interstitial Fluid Flow in the Skeletal Muscle Endomysium. Journal of the Mechanical Behavior of Biomedical Materials 2020, 102, 103504. https://doi.org/10.1016/j.jmbbm.2019.103504.
Pei S, Parthasarathy S, Parajuli A, Martinez J, Lv M, Jiang S, Wu D, Wei S, Lu XL, Farach-Carson MC, Kirn-Safran CB, Wang L. Perlecan/Hspg2 Deficiency Impairs Bone’s Calcium Signaling and Associated Transcriptome in Response to Mechanical Loading. Bone 2020, 131, 115078. https://doi.org/10.1016/j.bone.2019.115078.
Parajuli A, Pei S, Zhao H, Martinez JR, Lu XL, Liu XS, Farach-Carson MC, Kirn-Safran CB, Wang L. Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton. Biomolecules 2020, 10 (2), 198. https://doi.org/10.3390/biom10020198.
Han B, Li Q, Wang C, Patel P, Adams SM, Doyran B, Nia HT, Oftadeh R, Zhou S, Li CY, Liu XS, Lu XL, Enomoto-Iwamoto M, Qin L, Mauck RL, Iozzo RV, Birk DE, Han L. Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix. ACS nano 2019, 13 (10), 11320. https://doi.org/10.1021/acsnano.9b04477
Zhou Y, Lv M, Li T, Zhang T, Duncan R, Wang L, Lu XL. Spontaneous Calcium Signaling of Cartilage Cells: From Spatiotemporal Features to Biophysical Modeling. The FASEB Journal 2019, 33 (4), 4675. https://doi.org/10.1096/fj.201801460R.
Lv M, Zhou Y, Polson SW, Wan LQ, Wang M, Han L, Wang L, Lu XL. Identification of Chondrocyte Genes and Signaling Pathways in Response to Acute Joint Inflammation. Sci Rep 2019, 9 (1), 93. https://doi.org/10.1038/s41598-018-36500-2.
Zhao W, Li T, Li Y, O’Brien DJ, Terrones M, Wei B, Suhr J, Lu XL. Mechanical Properties of Nanocomposites Reinforced by Carbon Nanotube Sponges. Journal of Materiomics 2018, 4 (2), 157–164. https://doi.org/10.1016/j.jmat.2018.01.006.
Zhang J, Liao L, Zhu J, Wan X, Xie M, Zhang H, Zhang M, Lu L, Yang H, Jing D, Liu X, Yu S, Lu XL, Chen C, Shan Z, Wang M. Osteochondral Interface Stiffening in Mandibular Condylar Osteoarthritis. J Dent Res 2018, 97 (5), 563–570. https://doi.org/10.1177/0022034517748562.
Lv M, Zhou Y, Chen X, Han L, Wang L, Lu XL. Calcium Signaling of in Situ Chondrocytes in Articular Cartilage under Compressive Loading: Roles of Calcium Sources and Cell Membrane Ion Channels. Journal of Orthopaedic Research 2018, 36 (2), 730. https://doi.org/10.1002/jor.23768.
Fleck AKM, Kruger U, Carlson K, Waltz C, McCallum SA, Lu XL, Wan LQ. Zonal Variation of MRI-Measurable Parameters Classifies Cartilage Degradation. Journal of Biomechanics 2017, 65, 176–184. https://doi.org/10.1016/j.jbiomech.2017.10.011.
Chandrasekaran P, Doyran B, Li Q, Han B, Bechtold TE, Koyama E, Lu XL, Han L. Biomechanical properties of murine TMJ articular disc and condyle cartilage via AFM-nanoindentation. Journal of Biomechanics 2017, 60. https://doi.org/10.1016/j.jbiomech.2017.06.031.
Doyran B, Tong W, Li Q, Jia H, Zhang X, Chen C, Enomoto-Iwamoto M, Lu XL, Qin L, Han L. Nanoindentation Modulus of Murine Cartilage: A Sensitive Indicator of the Initiation and Progression of Post-Traumatic Osteoarthritis. Osteoarthritis and Cartilage 2017, 25 (1), 108–117. https://doi.org/10.1016/j.joca.2016.08.008.
Zhang H, Cui JW, Lu XL, Wang MQ. Finite Element Analysis on Tooth and Periodontal Stress under Simulated Occlusal Loads. Journal of Oral Rehabilitation 2017, 44 (7), 526–536. https://doi.org/10.1111/joor.12512.
Jia H, Ma X, Tong W, Doyran B, Sun Z, Wang L, Zhang X, Zhou Y, Badar F, Chandra A, Lu XL, Xia Y, Han L, Enomoto-Iwamoto M, Qin L. EGFR Signaling Is Critical for Maintaining the Superficial Layer of Articular Cartilage and Preventing Osteoarthritis Initiation. Proceedings of the National Academy of Sciences of the United States of America 2016, 113 (50), 14360. https://doi.org/10.1073/pnas.1608938113.
Abu-Hakmeh A, Kung A, Mintz BR, Kamal S, Cooper JA, Lu XL, Wan LQ. Sequential Gelation of Tyramine-Substituted Hyaluronic Acid Hydrogels Enhances Mechanical Integrity and Cell Viability. Med Biol Eng Comput 2016, 54 (12), 1893–1902. https://doi.org/10.1007/s11517-016-1474-0.
Fan L, Pei S, Lu XL, Wang L. A Multiscale 3D Finite Element Analysis of Fluid/Solute Transport in Mechanically Loaded Bone. Bone research 2016, 4. https://doi.org/10.1038/boneres.2016.32.
Zhou Y, David MA, Chen X, Wan LQ, Duncan R, Wang L, Lu XL. Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes. Annals of biomedical engineering 2016, 44 (4), 1138. https://doi.org/10.1007/s10439-015-1406-4.
Chen X, Zhou Y, Wang L, Santare MH, Wan LQ, Lu XL. Determining Tension-Compression Nonlinear Mechanical Properties of Articular Cartilage from Indentation Testing. Annals of biomedical engineering 2016, 44 (4), 1148. https://doi.org/10.1007/s10439-015-1402-8.
Han B, Chery DR, Yin J, Lu XL, Lee D, Han L. Nanomechanics of Layer-by-Layer Polyelectrolyte Complexes: A Manifestation of Ionic Cross-Links and Fixed Charges. Soft Matter 2016, 12 (4), 1158–1169. https://doi.org/10.1039/C5SM01430A.
Zhao W, Elias AL, Rajukumar LP, Kim HI, O’Brien DJ, Zimmerman BK, Penev ES, Terrones M, Yakobson BI, Wei B, Lu XL, Suhr J. Controllable and Predictable Viscoelastic Behavior of 3D Boron-Doped Multiwalled Carbon Nanotube Sponges. Particle & Particle Systems Characterization 2016, 33 (1), 21–26. https://doi.org/10.1002/ppsc.201500136.
Zhao W, Shan C, Elias AL, Rajukumar LP, O’Brien DJ, Terrones M, Wei B, Suhr J, Lu XL. Hyperelasticity of Three-Dimensional Carbon Nanotube Sponge Controlled by the Stiffness of Covalent Junctions. Carbon 2015, 95, 640–645. https://doi.org/10.1016/j.carbon.2015.08.068.
Parajuli A, Liu C, Li W, Gu X, Lai X, Pei S, Price C, You L, Lu XL, Wang L. Bone’s Responses to Mechanical Loading Are Impaired in Type I Diabetes. Bone 2015, 81, 152. https://doi.org/10.1016/j.bone.2015.07.012.
Ruggiero L, Zimmerman BK, Park M, Han L, Wang L, Burris DL, Lu XL. Roles of the Fibrous Superficial Zone in the Mechanical Behavior of TMJ Condylar Cartilage. Ann Biomed Eng 2015, 43 (11), 2652–2662. https://doi.org/10.1007/s10439-015-1320-9.
Moore AC, Zimmerman BK, Chen X, Lu XL, Burris DL. Experimental Characterization of Biphasic Materials Using Rate-Controlled Hertzian Indentation. Tribology international 2015, 89, 2. https://doi.org/10.1016/j.triboint.2015.02.001.
Li Q, Doyran B, Gamer LW, Lu XL, Qin L, Ortiz C, Grodzinsky AJ, Rosen V, Han L. Biomechanical Properties of Murine Meniscus Surface via AFM-Based Nanoindentation. Journal of biomechanics 2015, 48 (8), 1364. https://doi.org/10.1016/j.jbiomech.2015.02.064.
Zhou Y, Park M, Cheung E, Wang L, Lu XL. The Effect of Chemically Defined Medium on Spontaneous Calcium Signaling of In Situ Chondrocytes during Long-Term Culture. Journal of biomechanics 2015, 48 (6), 990. https://doi.org/10.1016/j.jbiomech.2015.02.005.
Singh AV, Raymond M, Pace F, Certo A, Zuidema JM, McKay CA, Gilbert RJ, Lu XL, Wan LQ. Astrocytes Increase ATP Exocytosis Mediated Calcium Signaling in Response to Microgroove Structures. Sci Rep 2015, 5 (1), 7847. https://doi.org/10.1038/srep07847.
Chen X, Zimmerman BK, Lu XL. Determine the Equilibrium Mechanical Properties of Articular Cartilage from the Short-Term Indentation Response. Journal of Biomechanics 2015, 48 (1), 176–180. https://doi.org/10.1016/j.jbiomech.2014.10.036.
Zimmerman BK, Bonnevie ED, Park M, Zhou Y, Wang L, Burris DL, Lu XL. Role of Interstitial Fluid Pressurization in TMJ Lubrication. J Dent Res 2015, 94 (1), 85–92. https://doi.org/10.1177/0022034514553626.
Lai X, Price C, Lu XL, Wang L. Imaging and Quantifying Solute Transport Across Periosteum: Implications for Muscle-Bone Crosstalk. Bone 2014, 66, 82. https://doi.org/10.1016/j.bone.2014.06.002.
Qiu J, Baik AD, Lu XL, Hillman EMC, Zhuang Z, Dong C, Guo XE. A Noninvasive Approach to Determine Viscoelastic Properties of an Individual Adherent Cell under Fluid Flow. Journal of biomechanics 2014, 47 (6), 1537. https://doi.org/10.1016/j.jbiomech.2014.01.056.
Jing D, Baik AD, Lu XL, Zhou B, Lai X, Wang L, Luo E, Guo XE. In Situ Intracellular Calcium Oscillations in Osteocytes in Intact Mouse Long Bones under Dynamic Mechanical Loading. The FASEB Journal 2014, 28 (4), 1582. https://doi.org/10.1096/fj.13-237578.
Zhou B, Liu XS, Wang J, Lu XL, Fields AJ, Guo XE. Dependence of Mechanical Properties of Trabecular Bone on Plate-Rod Microstructure Determined by Individual Trabecula Segmentation (ITS). Journal of biomechanics 2014, 47 (3), 702. https://doi.org/10.1016/j.jbiomech.2013.11.039.
Shan C, Zhao W, Lu XL, O’Brien DJ, Li Y, Cao Z, Elias AL, Cruz-Silva R, Terrones M, Wei B, Suhr J. Three-Dimensional Nitrogen-Doped Multiwall Carbon Nanotube Sponges with Tunable Properties. Nano Lett. 2013, 13 (11), 5514–5520. https://doi.org/10.1021/nl403109g.
Jing D, Lu XL, Luo E, Sajda P, Leong PL, Guo XE. Spatiotemporal Properties of Intracellular Calcium Signaling in Osteocytic and Osteoblastic Cell Networks under Fluid Flow. Bone 2013, 53 (2), 531. https://doi.org/10.1016/j.bone.2013.01.008.
Lu XL, Huo B, Park M, Guo XE. Calcium Response in Osteocytic Networks under Steady and Oscillatory Fluid Flow. Bone 2012, 51 (3), 466. https://doi.org/10.1016/j.bone.2012.05.021.
Lu XL, Huo B, Chiang V, Guo XE. Osteocytic Network Is More Responsive in Calcium Signaling than Osteoblastic Network under Fluid Flow. Journal of Bone and Mineral Research 2012, 27 (3), 563. https://doi.org/10.1002/jbmr.1474.
Su JH, Xu F, Lu XL, Lu TJ. Fluid Flow Induced Calcium Response in Osteoblasts: Mathematical Modeling. Journal of Biomechanics 2011, 44 (11), 2040–2046. https://doi.org/10.1016/j.jbiomech.2011.05.004.
Qiu J, Baik AD, Lu XL, Hillman EMC, Zhuang Z, Guo XE. Theoretical Analysis of Novel Quasi-3D Microscopy of Cell Deformation. Cellular and molecular bioengineering 2011, 5 (2), 165. https://doi.org/10.1007/s12195-011-0218-3.
Baik AD, Lu XL, QiuJ, Huo B, Hillman EMC, Dong C, Guo XE. Quasi-3D Cytoskeletal Dynamics of Osteocytes under Fluid Flow. Biophysical Journal 2010, 99 (9), 2812. https://doi.org/10.1016/j.bpj.2010.08.064.
Wan LQ, Kang S M, Eng G, Grayson WL, Lu XL, Huo B, Gimble J, Guo XE, Mow VC, Vunjak-Novakovic G. Geometric Control of Human Stem Cell Morphology and Differentiation. Integrative biology : quantitative biosciences from nano to macro 2010, 2 (0), 346. https://doi.org/10.1039/c0ib00016g.
Maleke C, Luo J, Gamarnik V, Lu XL, Konofagou EE. Simulation Study of Amplitude-Modulated (AM) Harmonic Motion Imaging (HMI) for Stiffness Contrast Quantification with Experimental Validation. Ultrason Imaging 2010, 32 (3), 154–176. https://doi.org/10.1177/016173461003200304.
Lu XL, Wan LQ, Guo XE, Mow VC. A Linearized Formulation of Triphasic Mixture Theory for Articular Cartilage, and Its Application to Indentation Analysis. Journal of Biomechanics 2010, 43 (4), 673–679. https://doi.org/10.1016/j.jbiomech.2009.10.026.
Yadav VK, Balaji S, Suresh PS, Liu XS, Lu X, Li Z, Guo XE, Mann JJ, Balapure AK, Gershon MD, Medhamurthy R, Vidal M, Karsenty G, Ducy P. Inhibition of Gut-Derived Serotonin Synthesis: A Potential Bone Anabolic Treatment. Nature medicine 2010, 16 (3), 308. https://doi.org/10.1038/nm.2098.
Huo B, Lu XL, Costa KD, Xu Q, Guo XE. An ATP-Dependent Mechanism Mediates Intercellular Calcium Signaling in Bone Cell Network under Single Cell Nanoindentation. Cell calcium 2010, 47 (3), 234. https://doi.org/10.1016/j.ceca.2009.12.005.
Huo B, Lu XL, Guo XE. Intercellular Calcium Wave Propagation in Linear and Circuit-like Bone Cell Networks. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2010, 368 (1912), 617. https://doi.org/10.1098/rsta.2009.0221.
Chan ME, Lu XL, Huo B, Baik AD, Chiang V, Guldberg RE, Lu HH, Guo XE. A Trabecular Bone Explant Model of Osteocyte–Osteoblast Co-Culture for Bone Mechanobiology. Cellular and molecular bioengineering 2009, 2 (3), 405. https://doi.org/10.1007/s12195-009-0075-5.
Mow VC, Lai WM, Setton LA, Gu W, Yao H, Wan LQ, Lu XL. Discussion: “On the Thermodynamical Admissibility of the Triphasic Theory of Charged Hydrated Tissues” (Huyghe, J. M., Wilson, W., and Malakpoor, K., ASME J. Biomech. Eng., 2009, 131, p. 044504). Journal of Biomechanical Engineering 2009, 131 (095501). https://doi.org/10.1115/1.3128727.
Lu XL, Mow VC, Guo XE. Proteoglycans and Mechanical Behavior of Condylar Cartilage. Journal of Dental Research 2009, 88 (3), 244. https://doi.org/10.1177/0022034508330432.
Huo B, Lu XL, Hung CT, Costa KD, Xu Q, Whitesides GM, Guo XE. Fluid Flow Induced Calcium Response in Bone Cell Network. Cellular and molecular bioengineering 2008, 1 (1), 58. https://doi.org/10.1007/s12195-008-0011-0.
Lu XL, Mow VC. Biomechanics of Articular Cartilage and Determination of Material Properties. Med Sci Sports Exerc 2008, 40 (2), 193–199. https://doi.org/10.1249/mss.0b013e31815cb1fc.
Lu XL, Miller C, Chen FH, Guo XE, Mow VC. The Generalized Triphasic Correspondence Principle for Simultaneous Determination of the Mechanical Properties and Proteoglycan Content of Articular Cartilage by Indentation. Journal of Biomechanics 2007, 40 (11), 2434–2441. https://doi.org/10.1016/j.jbiomech.2006.11.015.
Lu XL, Sun DDN, Guo XE, Chen FH, Lai WM, Mow VC. Indentation Determined Mechanoelectrochemical Properties and Fixed Charge Density of Articular Cartilage. Annals of biomedical engineering 2004, 32 (3). https://doi.org/10.1023/b:abme.0000017534.06921.24.
BOOK & BOOK CHAPTERS
- Yao H, Wu Y, Lu XL.
- “Cartilage Mechanobiology”, in Mechanobiology Handbook, edited by Jiro Nagatomi.ISBN: 9781420091212, Taylor & Francis Group LLC, 2010 (work after joining UD)
- Mow VC, Lu XL, Wan LQ.
- “Rigorous Mechanics And Elegant Mathematics Formulation of Constitutive Laws for Complex Materials: An Example from Biomechanics”, in From Waves in Complex Systems to Dynamics of Generalized Continua, ISBN: 9789814340717, World Scientific Publishing Company, 2010.
- Huo B, Lu XL, Guo XE.
- “Fluid Flow Induced Calcium Response in Bone Cell Network”, in Tributes to Yuan-Cheng Fung on His 90th Birthday: Biomechanics, from Molecules to Man, edited by Shu Chien et al., ISBN: 9789814289870 World Scientific Publishing Company, 2009
- Lu X, Zhang T.
- “Engineering Design Graphics – AutoCAD 2000”, in Chinese, ISBN：9787114034374. China Communications Press, Beijing, China, 2000