The Day Lab develops innovative nanomaterials that enable high precision therapy of cancer and other diseases, and elucidates how nanoparticle architecture impacts function by studying nano/bio interactions from the subcellular to whole organism level. The nanoparticles we develop enable high precision by: (1) binding to and inhibiting molecules that are expressed exclusively in diseased cells, (2) remaining in an inactive state until they are activated in diseased cells by externally applied tissue-penetrating near-infrared light, or (3) using cell-derived membranes as coatings to avoid detection by the immune system and facilitate cell-specific cargo delivery. Our research is at the forefront of nanomedicine, and is advancing the field by revealing important information regarding the design and implementation of nanoparticles for therapeutic applications. In the future, the technologies we develop may transform the way we manage diseases such as cancer, blood disorders, pregnancy-related conditions, and more.
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