Biomimicry is an exciting subfield of nanomedicine. At its forefront is the use of cell-derived membranes to coat nanoparticles. Membrane-wrapped nanoparticles can avoid immune recognition and bind homologous cells in vitro and in vivo, as depicted above. In the Day Lab, we are developing membrane-wrapped nanoparticles for targeted cargo delivery to hematopoietic stem and progenitor cells and cancer cells. In the future, these nanoparticles could transform the way we manage diseases such as cancers, blood disorders, and more.
- Scully MA, Wilkins DE, Dang MN, Hoover EC, Aboeleneen SB, Day ES. Cancer cell membrane wrapped nanoparticles for the delivery of a Bcl2 inhibitor to triple-negative breast cancer. Molecular Pharmaceutics. 2023; 20(8): 3895–3913.
- Das S*, Harris JC*, Winter EJ, Kao C-Y, Day ES#, Papoutsakis ET#. Megakaryocyte membrane-wrapped nanoparticles for targeted cargo delivery to hematopoietic stem and progenitor cells. Bioengineering & Translational Medicine. 2023; 8(3): e10456. *co-first authors; #co-corresponding authors
- Harris JC, Sterin EH, Day ES. Membrane-wrapped nanoparticles for enhanced chemotherapy of acute myeloid leukemia. ACS Biomaterials Science & Engineering. 2022; 8(10): 4439-4448.
- Aboeleneen SB, Scully MA, Harris JC, Sterin EH, Day ES. Membrane-wrapped nanoparticles for photothermal cancer therapy. Nano Convergence. 2022; 9: 37.
Scully MA, Sterin EH, Day ES. Membrane-wrapped nanoparticles for nucleic acid delivery. Biomaterials Science. 2022; 10: 4378-4391.
- Harris JC, Scully MA, Day ES. Cancer cell membrane-coated nanoparticles for cancer management. Cancers. 2019; 11: 1836.
- Valcourt DM, Harris J, Riley RS, Dang M, Wang J, Day ES. Advances in targeted nanotherapeutics: from bioconjugation to biomimicry. Nano Research. 2018; 11(10): 4999-5016. 2018 Young Innovator Award in Nanobiotechnology.