Biomimicry is an exciting new subfield of nanomedicine, and at its forefront is the use of cell-derived membranes to coat nanoparticles. Membrane-wrapped nanoparticles can avoid immune recognition and bind homologous cells in vitro and in vivo, as depicted above. In the Day Lab, we are developing membrane-wrapped nanoparticles for targeted cargo delivery to either hematopoietic stem and progenitor cells or cancer cells. In the future, these nanoparticles could transform the way we manage diseases such as cancer, blood disorders, and more.
1. Harris JC, Scully MA, Day ES. Cancer cell membrane-coated nanoparticles for cancer management. Cancers. 2019; 11: 1836.
2. Valcourt DM, Harris J, Riley RS, Dang M, Wang J, Day ES. Advances in targeted nanotherapeutics: from bioconjugation to biomimicry. Nano Research. 2018; 11(10): 4999-5016. 2018 Young Innovator Award in Nanobiotechnology.