Synthetic Chemistry Core Facility
Empowering researchers with the power of custom chemical synthesis and a universe of possibilities.
Synthetic Chemistry Core Facility (SCCF)
Since 2021, the COBRE supported Synthetic Chemistry Core Facility (SCCF) at UD provides convenient small molecule custom synthesis service to facilitate the scientific research program at the University of Delaware and other institutes. The SCCF offers expert support consultation and guidance for chemists and non-chemistry experts.
In-House Services
The core can support the synthesis of a broad range of small molecules. ●Substrates ●inhibitors ●agonists ●antagonists and other therapeutic probes and leads. ●Fluorescent probes ●bioorthogonal handles including azide/ alkyne, TCO, tetrazine, DHT ●Stable isotope labeled compounds ●Photo-caged compounds ●Photoaffinity probes ●Linkers ●Custom polymerization monomers ●Custom Phorphoramidites for DNA (or RNA synthesis) ●non-standard amino acids ●metabolic probes and precursors ●Small molecule purification and characterization.
State of the Art Resources
The SCCF is equipped with state-of-the-art instrumentation and capabilities, including GENESIS glove box, two CombiFlash NextGen 300+ flash chromatography system, JC Meyer solvent systems, Biotage® V-10 Touch, Teledyne Isco ACCQPrep HP150 chromatography system, Bruker 400 MHz NMR (shared), Waters UPLC, H-Class/SQD2
Expert Chemical Liaison
Sometimes projects can be done cheaper or faster by working with a CRO or partner facility. When working with an outside CRO, it is still essential to have an experienced chemist. We can help clients find the right company, negotiate the service charge, communicate with the service team, evaluate analytical data (NMR, MS, HPLC etc.), and ensure the quality of the product delivered. The core manager has established relationships working with multiple CROs. The SCCF can also work with the High-Throughput Experimentation Core to develop new synthetic protocols and reaction conditions.
Meet the Synthetic Chemistry Core Facility Manager:
Dr. Yinzhi Fang, Ph.D.
With over 15 years of synthetic chemistry experience Dr. Fang has synthesized over 50 distinct chemical compounds in the past 3 years. He has worked with over 20 different research groups and organizations.
The Synthetic Chemistry Core Facility is integrated within iLab system
External users should contact the core manager
For internal users, please take the following steps to submit your service request:
Getting Started with iLab:
1. Login (https://udel.ilabsolutions.com/service_center/show_external/6208/synthetic_chemistry_core_facility) using your iLab username and password. (IMPORTANT: On initial login, set your account time zone, click ‘update’, then log out once to set the change.)
2. Select a core from the list of cores at the University of Delaware by clicking the ‘core facilities’ list in the left-hand menu.
3. Once on the core’s page, click the ‘about our core’ tab to learn more about the available services
Create a Service Request:
If your lab has an iLab account with assigned Purpose Code(s), you can create service requests. External users should contact the core manager.
1. Navigate to the core page: https://udel.ilabsolutions.com/sc/6208/synthetic-chemistry-core-facility
2. Enter the username and password provided by iLab and click the “login” button.
3. Select the Request Services tab and click on the ‘Request Service’ under service of interest.
4. You will need to complete a form before submitting your request.
5. Your request will be pending until reviewed and accepted.
Contact us
Core Manager:
Yinzhi Fang, Ph.D. Department of Chemistry & Biochemistry, University of Delaware
302-277-756
yinzhif@udel.edu
Business Officer (internal user):
Dawn Yasik, Department of Chemistry & Biochemistry University of Delaware
(302)831-2433
dyasik@udel.edu
Business Officer (external user):
Eileen Adams, Financial Processor II, University of Delaware
ewadams@udel.edu
We welcome your questions and inquiries.
The SCCF is located at the
Ammon-Pinizzotto Pharmaceutical Innovation Center on the University of Delaware’s STAR Campus:
590 Avenue 1743
Newark, DE 19713
