Fromen Lab Publications from UD
Yu, Y., Zhang, N., Hoffman, D., Rastogi, D., Woodward, I.R., Fromen, C.A., Design and Evaluation of 3D-printed Lattice Structures as High Flow Rate Aerosol Filters. ACS Applied Engineering Materials (2024) just accepted
Woodward, I.R., Yu, Yinkui, Fromen, C.A., Experimental Full-volume Airway Approximation for Assessing Breath-dependent Regional Aerosol Deposition (2024) 100514
Sudduth, E., Lopez Ruiz, A., Trautmann-Rodriguez, M., Fromen, C.A., Age-Dependent Changes in Phagocytic Activity: in vivo Response of Mouse Pulmonary Antigen Presenting Cells to Direct Lung Delivery of Charged PEGDA Nanoparticles. J Nanobiotechnology 22:476 (2024).
Graf, J.,* Bomb, K.,* Trautmann-Rodriguez, Jarai, B.M., Gill, N.,, Kloxin, A.M.,# Fromen, C.A.,# Macrophage variance: investigating how macrophage origin influences responses to soluble and physical cues with immortalized vs. primary cells in 2D and 3D culture. Frontiers in Biomaterials Science 3 (2024) DOI: 10.3389/fbiom.2024.1399448
López Ruiz, A.,* Slaughter, E.,* Kloxin, A.M.,# Fromen, C.A.,# Bridging the gender gap in autoimmunity with T-cell targeted biomaterials. Current Opinion in Biotechnology (2024)
Woodward, I.R., Fromen, C.A., Recent developments in aerosol pulmonary drug delivery: new technologies, new cargos, and new targets. Annual Reviews in Biomedical Engineering. (2024) Accepted
Bartlett, B.A., Feng, Y., Fromen, C.A., Ford Versypt, A.N. Computational Modeling of Aerosol Particle Transport through Lung Mucosa. Computers and Chemical Engineering 179 (2023) 108458.
Graf, J., Trautmann-Rodriguez, M., Sabnis, S., Kloxin, A.M.,# Fromen, C.A.,# On the Path to Predicting Immune Responses in the Lung: Modeling the Pulmonary Innate Immune system at the Air-Liquid Interface (ALI). European Journal Pharmaceutical Science. (2023) Just Accepted.
Kolewe, E.L., Padhye, S., Woodward, I.R., Feng, Y., Briddell, J.W., Fromen, C.A., A pediatric upper airway library to evaluate interpatient variability of in silico aerosol deposition. AAPS PharmSciTech (2023)
Bomb, K.,* Zhang, Q.,* Fromen, C.A.,# Kloxin, A. M.,# Site-specific D-amino acid substitution to control peptide and hydrogel degradation in cellular microenvironments. ACS Macro Letters. 12 (2023)
Sudduth, E.,* Trautmann-Rodriguez, M.,* Gill, N., Bomb, K., Fromen, C.A., Aerosol Pulmonary Immune Engineering. Advanced Drug Delivery Reviews (2023)
Jarai, B.M., Bomb, K., Fromen, C.A., Nanoparticle Pre-treatment for Enhancing the Survival and Activation of Pulmonary Macrophage Transplant Therapy. Drug Delivery and Translational Research (2023)
Stillman, Z., Decker, G.E., Dworzak, M.R., Bloch, E.D., Fromen, C.A., Aluminum-Based Metal-Organic Framework Nanoparticles as Pulmonary Vaccine Adjuvants. J Nanobiotechnology 21 (2023) 39. DOI: 10.1186/s12951-023-01782-w.
Sudduth, E.R., Kolewe, E.L., Graf, J., Yu, Y., Somma, J., Fromen, C.A., Nebulization of Model Hydrogel Nanoparticles to Macrophages at the Air-Liquid Interface. Frontiers in Chemical Engineering (2023) 4, DOI: 10.3389/fceng.2022.1086031.
Bomb, K.,* LeValley, P.J.,* Woodward, I.R., Cassel, S.E., Yun, Z., Sutherland, B., Bhattacharjee, A., Steen, J., Kurdzo, E., McCoskey, J., Burris, D., Levine, K., Carbrello, C., Lenhoff, A.M., Fromen, C.A.,# Kloxin, A.M.# Cell therapy biomanufacturing: uniting biomaterial and flow-based membrane technologies for production of engineered T-cells, Advanced Materials Technologies (2022)
Kolewe, E.L., Padhye, S., Woodward, I.R., Wee, J., Rahman, T., Feng, Y., Briddell, J.W., Fromen, C.A., Spatial aerosol deposition correlated to anatomic feature development in 6-year-old upper airway computational models. Comput Biol Med (2022).
Bomb, K., Pradhan, L., Qi, Z., Jarai, B.M., Bhattacharjee, A., Burris, D., Kloxin, A.M.,* Fromen, C.A.,* Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic Interleukin 13 impair alveolar macrophage phenotype and function. Biomaterials Science (2022)
https://doi.org/10.1039/D2BM00828A
part of the Biomaterials Science Emerging Investigator Series
Jarai, B.M., Fromen, C.A. Nanoparticle Internalization Promotes the Survival of Primary Macrophages. Advanced NanoBiomed Research (2022)
Woodward, I.R., Fromen, C.A. Scalable, process-oriented beam lattices: generation, characterization, and compensation for open cellular structures. Additive Manufacturing (2021)
Woodward, I.R., Attia, L.M., Patel, P. Fromen, C.A. Scalable 3D Printed Lattices for Pressure Control in Fluid Applications. AIChE J (2021) DOI: 10.1002/aic.17452 Invited for 2021 Futures Issue
https://doi.org/10.1002/aic.17452
https://udspace.udel.edu/handle/19716/29934
Ro, E, Fromen, C.A., Sullivan, M.O. Inhalable mRNA vaccines for respiratory diseases: A roadmap. Current Opinion in Biotechnology (2021) in press.
Jarai, B.M., Stillman, Z., Fromen, C.A. Hydrogel Nanoparticle Degradation Influences the Activation and Survival of Primary Macrophages. J Mat Chem B (2021) Invited for 2021 Emerging Investigators Themed Issue
Kolewe, E.L., Stillman, Z.S., Woodward, I.R., Fromen, C.A., Check the Gap: Facemask Performance and Exhaled Aerosol Distributions Around the Wearer. PLOS ONE (2020).
Jarai, B.M., Stillman, Z.S., Bomb, K., Kloxin, A. M., Fromen, C.A. Biomaterials-Based Opportunities to Engineer the Pulmonary Host Immune Response in COVID-19. ACS Biomaterials Science & Engineering (2020)
Jarai, B.M.*, Stillman, Z.*, Attia, L., Decker. G.E., Bloch, E.D., Fromen, C.A., Evaluating UiO-66 Metal-Organic Framework (MOF) Nanoparticles as Acid-Sensitive Carriers for Pulmonary Drug Delivery Applications. ACS Appl Mater Interfaces (2020)
Peterman, E.L., Kolewe, E.L., Fromen, C.A., Evaluating Regional Pulmonary Deposition Using Patient-Specific 3D Printed Lung Models. JOVE Bioengineering (2020)
Kolewe, E.L., Feng, Y., Fromen, C.A., Realizing Lobe-Specific Aerosol Targeting in a 3D Printed In Vitro Lung Model. J Aerosol Med Pulm D (2020)
Shirazi, J., Donzanti, M.J., Nelson, K.M., Zurakowski, R., Fromen, C.A., Gleghorn, J.P., Significant unresolved questions and opportunities for bioengineering in understanding and treating COVID-19 disease progression. Cell Mol Bioeng (2020)
Briddell, J.W., Vandjelovic, N.D., Fromen, C.A., Peterman, E.L., Reilly, J.S., Geometric model to predict improvement after lingual frenulectomy for ankyloglossia. Int J Pediatr Otorhinolaryngol 134 (2020) 110063.
Stillman, Z.S., Jarai, B.M., Raman, N., Patel, P., Fromen, C.A., Degradation Profiles of Poly(ethylene glycol) diacrylate (PEGDA)-based hydrogel nanoparticles. Polym Chem 11:2 (2020) 568-580. Invited for 2020 Emerging Investigators Collection
Zhao, J., Feng, Y., Fromen, C.A., Glottis Motion Effects on Inhaled Particle Transport and Deposition in a Subject-Specific Human Mouth-to-Trachea Model: An in silico Study. Comput Biol Med 116 (2020) 103532.
https://doi.org/10.1016/j.compbiomed.2019.103532
Decker, G.,* Stillman, Z.S.,* Attia, L., Fromen, C.A.,# Bloch, E.#, Controlling Size, Defectiveness, and Fluorescence in Nanoparticle UiO-66 Through Water and Ligand Modulation. Chem Mater 31:13 (2019) 4831-4839.
https://doi.org/10.1021/acs.chemmater.9b01383
Publications Prior to UD
Kelley, W.J., Onyskiw, P. Fromen, C.A., Eniola-Adefeso, O., Model Particulate Drug Carriers Modulate Leukocyte Adhesion in Human Blood Flows. ACS Biomater Sci Eng 5:12 (2019) 6530-6540.
Kelley, W.J., Fromen, C.A., Lopez-Cazares, G., Eniola-Adefeso, O., PEGylation of model drug carriers enhances phagocytosis by primary human neutrophils. Acta Biomater 71:1 (2018) 283-293.
Noble, J., Zimmerman, A., Fromen, C.A., Potent Immune Stimulation from” Nanoparticle Carriers Relies on the Interplay of Adjuvant Surface Density and Adjuvant Mass Distribution. ACS Biomater Sci Eng 3:4 (2017) 560-571.
Fromen, C.A., Kelley, W.J., Fish, M.B., Adili, R., Noble, J., Hoenerhoff, M.J., Holinstat, M., Eniola-Adefeso, O., Neutrophil-Particle Interactions in Blood Circulation Drive Particle Clearance and Alter Neutrophil Responses in Acute Inflammation. ACS Nano 11:11 (2017) 10797–10807.
Fish, M.B., Fromen, C.A., Lopez-Cazares, G., Golinski, A.W., Scott, T.F., Adili, R., Holinstat, M., Eniola-Adefeso, O., Exploring Deformable Particles in Vascular-Targeted Drug Delivery: Softer is Only Sometimes Better. Biomaterials 124 (2017) 169-179.
Fromen, C.A., Fish, M.B., Zimmerman, A., Adili, R. Holinstat, M., Eniola-Adefeso, O, Evaluation of Receptor-Ligand Mechanisms of Dual-Targeted Particles to an Inflamed Endothelium. Bioeng Transl Med 1 (2016) 103-115.
Rahhal, T.B., Fromen, C.A., Wilson, E.M., Kai, M.P., Shen, T.W., Luft, J.C., DeSimone, J.M., Pulmonary Delivery of Butyrylcholinesterase as a Model Protein to the Lung. Mol Pharmaceutics 13:5 (2016) 1626-1635.
Fromen, C.A., Rahhal, T.B., Robbins, G.R., Kai, M.P., Shen, T.W., Luft, J.C., DeSimone, J.M, Nanoparticle Surface Charge Impacts Distribution, Uptake and Lymph Node Trafficking by Pulmonary Antigen-Presenting Cells. Nanomed. Nanotechnol, Biol, Med 12:3 (2016) 677-687. – Featured Cover Article
Kai, M.P., Brighton, H.E., Fromen, C.A., Shen, T.W., Luft, J.C., Luft, Y.E., Keeler, A.W., Robbins, G.R., Ting, J.P.Y., Zamboni, W.C., Bear, J.E., DeSimone, J.M., Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance. ACS Nano 10:1 (2016) 861-870.
Fromen, C.A.*, Robbins, G.R.*, Shen, T.W., Kai, M.P., Ting, J.P.Y., DeSimone, J.M., Controlled Analysis of Nanoparticle Charge on Mucosal and Systemic Antibody Responses Following Pulmonary Immunization. Proc Natl Acad Sci USA 112 (2015) 488-493.
Shen, T.W.*, Fromen, C.A.*, Kai, M.P., Luft, J.C., Rahhal, T.R., Robbins, G.R., DeSimone, J.M., Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery. Pharm Res 32 (2015) 3248-3260.
Fish, M.B., Thompson, A.J., Fromen, C.A., Eniola-Adefeso, O., Emergence and Utility of Non-Spherical Particles in Biomedicine. Ind Eng Chem Fundam 56:16 (2015) 4043-4059.
Robbins, G.R., Fromen, C.A., Rahhal, T.B., Luft, J.C., Wang, A.Z., Pecot, C.V., DeSimone, J.M., “Non-Intravenous Routes of Delivery: Aerosol Therapy for Cancer Management” in NCI Alliance for Nanotechnology in Cancer: Cancer Nanotechnology Plan 2015. Section I: Emerging Strategies in Cancer Nanotechnolgy (2015) 39-43.
Sobczynski, D.J., Fish, M.B., Fromen, C.A., Carrasco-Teja, M., Coleman, R.M., Eniola-Adefeso, O., Drug Carrier Interactions in Blood. Ther Deliv 6:8 (2015) 916-934.
Petrosko, S.A., Fromen, C.A., Auyeung, E., DeSimone, J.M., Mirkin, C.A., Nanotechnology: an Enduring Bridge Between Engineering and Medicine. National Academy of Engineering, The Bridge (2013) 7-15.
Fromen, C.A., Shen, T.W., Larus, A.E., Mack, P., Luft, J.C., Maynor, B.W., DeSimone, J.M., Synthesis and Characterization of Monodisperse Uniformly Shaped Respirable Aerosols. AIChE Journal 59:9 (2013) 3184-3194.
Garcia A., Mack P., Williams, S., Fromen, C.A., Shen, T.W., Pillai, J., Kuehl, P., Napier, M.E., DeSimone, J.M., Maynor, B.W., Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications. Journal of Drug Delivery (2011) 941243.
Wang, Y., Merkel, T.J., Chen, K.; Fromen, C.A., Betts, D.E., DeSimone, J.M., Generation of a Library of Particles Having Controlled Sizes and Shapes via the Mechanical Elongation of Master Templates. Langmuir 27 (2011) 524-528.
Cox, G.P., Marshall, K.L., Lambropoulos, J.C., Leitch, M., Fromen, C.A., Jacobs, S.D., Modeling the Effects of Microencapsulation on the Electro-Optic Behavior of Polymer Cholesteric Liquid Crystal Flakes. J Appl Phys 106 (2009) 24911-1.