Fromen Lab Publications from UD

Jarai, B.M.*, Stillman, Z.*, Attia, L., Decker. G.E., Bloch, E.D., Fromen, C.A., Evaluating UiO-66 Metal-Organic Framework (MOF) Nanoparticles as Acid-Sensitive Carriers for Pulmonary Drug Delivery Applications. ACS Appl Mater Interfaces (2020)

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Peterman, E.L., Kolewe, E.L., Fromen, C.A., Evaluating Regional Pulmonary Deposition Using Patient-Specific 3D Printed Lung Models. JOVE Bioengineering (2020) 

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Kolewe, E.L., Feng, Y., Fromen, C.A., Realizing Lobe-Specific Aerosol Targeting in a 3D Printed In Vitro Lung Model. J Aerosol Med Pulm D (2020) 

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Shirazi, J., Donzanti, M.J., Nelson, K.M., Zurakowski, R., Fromen, C.A., Gleghorn, J.P., Significant unresolved questions and opportunities for bioengineering in understanding and treating COVID-19 disease progression. Cell Mol Bioeng (2020)

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Briddell, J.W., Vandjelovic, N.D., Fromen, C.A., Peterman, E.L., Reilly, J.S., Geometric model to predict improvement after lingual frenulectomy for ankyloglossia. Int J Pediatr Otorhinolaryngol 134 (2020) 110063.

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Stillman, Z.S., Jarai, B.M., Raman, N., Patel, P., Fromen, C.A., Degradation Profiles of Poly(ethylene glycol) diacrylate (PEGDA)-based hydrogel nanoparticles. Polym Chem 11:2 (2020) 568-580. Invited for 2020 Emerging Investigators Collection

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Zhao, J., Feng, Y., Fromen, C.A., Glottis Motion Effects on Inhaled Particle Transport and Deposition in a Subject-Specific Human Mouth-to-Trachea Model: An in silico Study. Comput Biol Med 116 (2020) 103532.

https://doi.org/10.1016/j.compbiomed.2019.103532

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Decker, G.,* Stillman, Z.S.,* Attia, L., Fromen, C.A.,# Bloch, E.#, Controlling Size, Defectiveness, and Fluorescence in Nanoparticle UiO-66 Through Water and Ligand Modulation. Chem Mater 31:13 (2019) 4831-4839.

https://doi.org/10.1021/acs.chemmater.9b01383

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Publications Prior to UD

Kelley, W.J., Onyskiw, P. Fromen, C.A., Eniola-Adefeso, O., Model Particulate Drug Carriers Modulate Leukocyte Adhesion in Human Blood Flows. ACS Biomater Sci Eng 5:12 (2019) 6530-6540.

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Kelley, W.J., Fromen, C.A., Lopez-Cazares, G., Eniola-Adefeso, O., PEGylation of model drug carriers enhances phagocytosis by primary human neutrophils. Acta Biomater 71:1 (2018) 283-293.

https://doi.org/10.1016/j.actbio.2018.09.001
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Noble, J., Zimmerman, A., Fromen, C.A., Potent Immune Stimulation from” Nanoparticle Carriers Relies on the Interplay of Adjuvant Surface Density and Adjuvant Mass Distribution. ACS Biomater Sci Eng 3:4 (2017) 560-571.

https://doi.org/10.1021/acsbiomaterials.6b00756
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Fromen, C.A., Kelley, W.J., Fish, M.B., Adili, R., Noble, J., Hoenerhoff, M.J., Holinstat, M., Eniola-Adefeso, O., Neutrophil-Particle Interactions in Blood Circulation Drive Particle Clearance and Alter Neutrophil Responses in Acute Inflammation. ACS Nano 11:11 (2017) 10797–10807.

https://doi.org/10.1021/acsnano.7b03190
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Fish, M.B., Fromen, C.A., Lopez-Cazares, G., Golinski, A.W., Scott, T.F., Adili, R., Holinstat, M., Eniola-Adefeso, O., Exploring Deformable Particles in Vascular-Targeted Drug Delivery: Softer is Only Sometimes Better. Biomaterials 124 (2017) 169-179.

https://doi.org/10.1016/j.biomaterials.2017.02.002
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Fromen, C.A., Fish, M.B., Zimmerman, A., Adili, R. Holinstat, M., Eniola-Adefeso, O, Evaluation of Receptor-Ligand Mechanisms of Dual-Targeted Particles to an Inflamed Endothelium. Bioeng Transl Med 1 (2016) 103-115.

https://doi.org/10.1002/btm2.10008
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Rahhal, T.B., Fromen, C.A., Wilson, E.M., Kai, M.P., Shen, T.W., Luft, J.C., DeSimone, J.M., Pulmonary Delivery of Butyrylcholinesterase as a Model Protein to the Lung. Mol Pharmaceutics 13:5 (2016) 1626-1635.

https://doi.org/10.1021/acs.molpharmaceut.6b00066
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Fromen, C.A., Rahhal, T.B., Robbins, G.R., Kai, M.P., Shen, T.W., Luft, J.C., DeSimone, J.M, Nanoparticle Surface Charge Impacts Distribution, Uptake and Lymph Node Trafficking by Pulmonary Antigen-Presenting Cells. Nanomed. Nanotechnol, Biol, Med 12:3 (2016) 677-687. – Featured Cover Article

https://doi.org/10.1016/j.nano.2015.11.002
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Kai, M.P., Brighton, H.E., Fromen, C.A., Shen, T.W., Luft, J.C., Luft, Y.E., Keeler, A.W., Robbins, G.R., Ting, J.P.Y., Zamboni, W.C., Bear, J.E., DeSimone, J.M., Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance. ACS Nano 10:1 (2016) 861-870.

https://doi.org/10.1021/acsnano.5b05999
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Fromen, C.A.*, Robbins, G.R.*, Shen, T.W., Kai, M.P., Ting, J.P.Y., DeSimone, J.M., Controlled Analysis of Nanoparticle Charge on Mucosal and Systemic Antibody Responses Following Pulmonary Immunization. Proc Natl Acad Sci USA 112 (2015) 488-493.

https://doi.org/10.1073/pnas.1422923112
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Shen, T.W.*, Fromen, C.A.*, Kai, M.P., Luft, J.C., Rahhal, T.R., Robbins, G.R., DeSimone, J.M., Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery. Pharm Res 32 (2015) 3248-3260.

https://dx.doi.org/10.1007%2Fs11095-015-1701-7
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Fish, M.B., Thompson, A.J., Fromen, C.A., Eniola-Adefeso, O., Emergence and Utility of Non-Spherical Particles in Biomedicine. Ind Eng Chem Fundam 56:16 (2015) 4043-4059.

https://doi.org/10.1021/ie504452j
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Robbins, G.R., Fromen, C.A., Rahhal, T.B., Luft, J.C., Wang, A.Z., Pecot, C.V., DeSimone, J.M., “Non-Intravenous Routes of Delivery: Aerosol Therapy for Cancer Management” in NCI Alliance for Nanotechnology in Cancer: Cancer Nanotechnology Plan 2015. Section I: Emerging Strategies in Cancer Nanotechnolgy (2015) 39-43.

https://www.cancer.gov/sites/nano/research/plan/cananoplan-2015-complete.pdf
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Sobczynski, D.J., Fish, M.B., Fromen, C.A., Carrasco-Teja, M., Coleman, R.M., Eniola-Adefeso, O., Drug Carrier Interactions in Blood. Ther Deliv 6:8 (2015) 916-934.

https://doi.org/10.4155/TDE.15.38
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Petrosko, S.A., Fromen, C.A., Auyeung, E., DeSimone, J.M., Mirkin, C.A., Nanotechnology: an Enduring Bridge Between Engineering and Medicine. National Academy of Engineering, The Bridge (2013) 7-15.

https://www.nae.edu/Publications/Bridge/88361/88391.aspx
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Fromen, C.A., Shen, T.W., Larus, A.E., Mack, P., Luft, J.C., Maynor, B.W., DeSimone, J.M., Synthesis and Characterization of Monodisperse Uniformly Shaped Respirable Aerosols. AIChE Journal 59:9 (2013) 3184-3194.

https://doi.org/10.1002/aic.14157
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Garcia A., Mack P., Williams, S., Fromen, C.A., Shen, T.W., Pillai, J., Kuehl, P., Napier, M.E., DeSimone, J.M., Maynor, B.W., Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications. Journal of Drug Delivery (2011) 941243.

http://dx.doi.org/10.1155/2012/941243
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Wang, Y., Merkel, T.J., Chen, K.; Fromen, C.A., Betts, D.E., DeSimone, J.M., Generation of a Library of Particles Having Controlled Sizes and Shapes via the Mechanical Elongation of Master Templates. Langmuir 27 (2011) 524-528.

https://doi.org/10.1021/la1045095
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Cox, G.P., Marshall, K.L., Lambropoulos, J.C., Leitch, M., Fromen, C.A., Jacobs, S.D., Modeling the Effects of Microencapsulation on the Electro-Optic Behavior of Polymer Cholesteric Liquid Crystal Flakes. J Appl Phys 106 (2009) 24911-1.

https://doi.org/10.1063/1.3272106
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