López Ruiz, A.,* Slaughter, E.,* Kloxin, A.M.,# Fromen, C.A.,# Bridging the gender gap in autoimmunity with T-cell targeted biomaterials. Current Opinion in Biotechnology (2024)

https://doi.org/10.1016/j.copbio.2024.103075

Woodward, I.R., Fromen, C.A., Recent developments in aerosol pulmonary drug delivery: new technologies, new cargos, and new targets. Annual Reviews in Biomedical Engineering. (2024) Accepted

https://doi.org/10.1146/annurev-bioeng-110122-010848 

Bartlett, B.A., Feng, Y., Fromen, C.A., Ford Versypt, A.N. Computational Modeling of Aerosol Particle Transport through Lung Mucosa. Computers and Chemical Engineering 179 (2023) 108458.

https://doi.org/10.1016/j.compchemeng.2023.108458

Graf, J., Trautmann-Rodriguez, M., Sabnis, S., Kloxin, A.M.,# Fromen, C.A.,# On the Path to Predicting Immune Responses in the Lung: Modeling the Pulmonary Innate Immune system at the Air-Liquid Interface (ALI). European Journal Pharmaceutical Science. (2023) Just Accepted.

https://doi.org/10.1016/j.ejps.2023.106596 

Kolewe, E.L., Padhye, S., Woodward, I.R., Feng, Y., Briddell, J.W., Fromen, C.A., A pediatric upper airway library to evaluate interpatient variability of in silico aerosol deposition. AAPS PharmSciTech (2023)

https://doi.org/10.1208/s12249-023-02619-3

Bomb, K.,* Zhang, Q.,* Fromen, C.A.,# Kloxin, A. M.,# Site-specific D-amino acid substitution to control peptide and hydrogel degradation in cellular microenvironments. ACS Macro Letters. 12 (2023)

https://doi.org/10.1021/acsmacrolett.3c00144

Sudduth, E.,* Trautmann-Rodriguez, M.,* Gill, N., Bomb, K., Fromen, C.A., Aerosol Pulmonary Immune Engineering. Advanced Drug Delivery Reviews (2023)

https://doi.org/10.1016/j.addr.2023.114831

Jarai, B.M., Bomb, K., Fromen, C.A., Nanoparticle Pre-treatment for Enhancing the Survival and Activation of Pulmonary Macrophage Transplant Therapy. Drug Delivery and Translational Research (2023) 

https://doi.org/10.1007/s13346-023-01319-6

Stillman, Z., Decker, G.E., Dworzak, M.R., Bloch, E.D., Fromen, C.A., Aluminum-Based Metal-Organic Framework Nanoparticles as Pulmonary Vaccine Adjuvants. J Nanobiotechnology 21 (2023) 39. DOI: 10.1186/s12951-023-01782-w.

https://doi.org/10.1186/s12951-023-01782-w

Sudduth, E.R., Kolewe, E.L., Graf, J., Yu, Y., Somma, J., Fromen, C.A., Nebulization of Model Hydrogel Nanoparticles to Macrophages at the Air-Liquid Interface. Frontiers in Chemical Engineering (2023) 4, DOI: 10.3389/fceng.2022.1086031.

https://doi.org/10.3389/fceng.2022.1086031

Bomb, K.,* LeValley, P.J.,* Woodward, I.R., Cassel, S.E., Yun, Z., Sutherland, B., Bhattacharjee, A., Steen, J., Kurdzo, E., McCoskey, J., Burris, D., Levine, K., Carbrello, C., Lenhoff, A.M., Fromen, C.A.,# Kloxin, A.M.# Cell therapy biomanufacturing: uniting biomaterial and flow-based membrane technologies for production of engineered T-cells, Advanced Materials Technologies (2022)

https://doi.org/10.1002/admt.202201155

Kolewe, E.L., Padhye, S., Woodward, I.R., Wee, J., Rahman, T., Feng, Y., Briddell, J.W., Fromen, C.A., Spatial aerosol deposition correlated to anatomic feature development in 6-year-old upper airway computational models. Comput Biol Med (2022).

https://doi.org/10.1016/j.compbiomed.2022.106058

Bomb, K., Pradhan, L., Qi, Z., Jarai, B.M., Bhattacharjee, A., Burris, D., Kloxin, A.M.,* Fromen, C.A.,* Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic Interleukin 13 impair alveolar macrophage phenotype and function. Biomaterials Science (2022)

https://doi.org/10.1039/D2BM00828A

part of the Biomaterials Science Emerging Investigator Series

Jarai, B.M., Fromen, C.A. Nanoparticle Internalization Promotes the Survival of Primary Macrophages. Advanced NanoBiomed Research (2022)

http://doi.org/10.1002/anbr.202100127

Advanced NanoBiomed Research 2022

Woodward, I.R., Fromen, C.A. Scalable, process-oriented beam lattices: generation, characterization, and compensation for open cellular structures. Additive Manufacturing (2021)

https://doi.org/10.1016/j.addma.2021.102386

https://udspace.udel.edu/handle/19716/32838 

Woodward, I.R., Attia, L.M., Patel, P. Fromen, C.A. Scalable 3D Printed Lattices for Pressure Control in Fluid Applications. AIChE J (2021) DOI: 10.1002/aic.17452 Invited for 2021 Futures Issue

https://doi.org/10.1002/aic.17452

https://udspace.udel.edu/handle/19716/29934

Ro, E, Fromen, C.A., Sullivan, M.O. Inhalable mRNA vaccines for respiratory diseases: A roadmap. Current Opinion in Biotechnology (2021) in press.

https://doi.org/10.1016/j.copbio.2021.10.017

Jarai, B.M., Stillman, Z., Fromen, C.A. Hydrogel Nanoparticle Degradation Influences the Activation and Survival of Primary Macrophages. J Mat Chem B (2021) Invited for 2021 Emerging Investigators Themed Issue

https://doi.org/10.1039/D1TB00982F

https://udspace.udel.edu/handle/19716/30126 

Kolewe, E.L., Stillman, Z.S., Woodward, I.R., Fromen, C.A., Check the Gap: Facemask Performance and Exhaled Aerosol Distributions Around the Wearer. PLOS ONE (2020).

https://doi.org/10.1371/journal.pone.0243885

Jarai, B.M., Stillman, Z.S., Bomb, K., Kloxin, A. M., Fromen, C.A. Biomaterials-Based Opportunities to Engineer the Pulmonary Host Immune Response in COVID-19. ACS Biomaterials Science & Engineering (2020)

https://doi.org/10.1021/acsbiomaterials.0c01287

Jarai, B.M.*, Stillman, Z.*, Attia, L., Decker. G.E., Bloch, E.D., Fromen, C.A., Evaluating UiO-66 Metal-Organic Framework (MOF) Nanoparticles as Acid-Sensitive Carriers for Pulmonary Drug Delivery Applications. ACS Appl Mater Interfaces (2020)

https://doi.org/10.1021/acsami.0c10900

Peterman, E.L., Kolewe, E.L., Fromen, C.A., Evaluating Regional Pulmonary Deposition Using Patient-Specific 3D Printed Lung Models. JOVE Bioengineering (2020) 

https://dx.doi.org/10.3791/61706

Kolewe, E.L., Feng, Y., Fromen, C.A., Realizing Lobe-Specific Aerosol Targeting in a 3D Printed In Vitro Lung Model. J Aerosol Med Pulm D (2020) 

http://doi.org/10.1089/jamp.2019.1564

Shirazi, J., Donzanti, M.J., Nelson, K.M., Zurakowski, R., Fromen, C.A., Gleghorn, J.P., Significant unresolved questions and opportunities for bioengineering in understanding and treating COVID-19 disease progression. Cell Mol Bioeng (2020)

https://doi.org/10.1007/s12195-020-00637-w

Briddell, J.W., Vandjelovic, N.D., Fromen, C.A., Peterman, E.L., Reilly, J.S., Geometric model to predict improvement after lingual frenulectomy for ankyloglossia. Int J Pediatr Otorhinolaryngol 134 (2020) 110063.

Stillman, Z.S., Jarai, B.M., Raman, N., Patel, P., Fromen, C.A., Degradation Profiles of Poly(ethylene glycol) diacrylate (PEGDA)-based hydrogel nanoparticles. Polym Chem 11:2 (2020) 568-580. Invited for 2020 Emerging Investigators Collection

Zhao, J., Feng, Y., Fromen, C.A., Glottis Motion Effects on Inhaled Particle Transport and Deposition in a Subject-Specific Human Mouth-to-Trachea Model: An in silico Study. Comput Biol Med 116 (2020) 103532.

Decker, G.,* Stillman, Z.S.,* Attia, L., Fromen, C.A.,# Bloch, E.#, Controlling Size, Defectiveness, and Fluorescence in Nanoparticle UiO-66 Through Water and Ligand Modulation. Chem Mater 31:13 (2019) 4831-4839.

Kelley, W.J., Onyskiw, P. Fromen, C.A., Eniola-Adefeso, O., Model Particulate Drug Carriers Modulate Leukocyte Adhesion in Human Blood Flows. ACS Biomater Sci Eng 5:12 (2019) 6530-6540.

Kelley, W.J., Fromen, C.A., Lopez-Cazares, G., Eniola-Adefeso, O., PEGylation of model drug carriers enhances phagocytosis by primary human neutrophils. Acta Biomater 71:1 (2018) 283-293.

Noble, J., Zimmerman, A., Fromen, C.A., Potent Immune Stimulation from” Nanoparticle Carriers Relies on the Interplay of Adjuvant Surface Density and Adjuvant Mass Distribution. ACS Biomater Sci Eng 3:4 (2017) 560-571.

Fish, M.B., Fromen, C.A., Lopez-Cazares, G., Golinski, A.W., Scott, T.F., Adili, R., Holinstat, M., Eniola-Adefeso, O., Exploring Deformable Particles in Vascular-Targeted Drug Delivery: Softer is Only Sometimes Better. Biomaterials 124 (2017) 169-179.

Fromen, C.A., Fish, M.B., Zimmerman, A., Adili, R. Holinstat, M., Eniola-Adefeso, O, Evaluation of Receptor-Ligand Mechanisms of Dual-Targeted Particles to an Inflamed Endothelium. Bioeng Transl Med 1 (2016) 103-115.

Rahhal, T.B., Fromen, C.A., Wilson, E.M., Kai, M.P., Shen, T.W., Luft, J.C., DeSimone, J.M., Pulmonary Delivery of Butyrylcholinesterase as a Model Protein to the Lung. Mol Pharmaceutics 13:5 (2016) 1626-1635.

Kai, M.P., Brighton, H.E., Fromen, C.A., Shen, T.W., Luft, J.C., Luft, Y.E., Keeler, A.W., Robbins, G.R., Ting, J.P.Y., Zamboni, W.C., Bear, J.E., DeSimone, J.M., Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance. ACS Nano 10:1 (2016) 861-870.

Fromen, C.A.*, Robbins, G.R.*, Shen, T.W., Kai, M.P., Ting, J.P.Y., DeSimone, J.M., Controlled Analysis of Nanoparticle Charge on Mucosal and Systemic Antibody Responses Following Pulmonary Immunization. Proc Natl Acad Sci USA 112 (2015) 488-493.

Shen, T.W.*, Fromen, C.A.*, Kai, M.P., Luft, J.C., Rahhal, T.R., Robbins, G.R., DeSimone, J.M., Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery. Pharm Res 32 (2015) 3248-3260.

Robbins, G.R., Fromen, C.A., Rahhal, T.B., Luft, J.C., Wang, A.Z., Pecot, C.V., DeSimone, J.M., “Non-Intravenous Routes of Delivery: Aerosol Therapy for Cancer Management” in NCI Alliance for Nanotechnology in Cancer: Cancer Nanotechnology Plan 2015. Section I: Emerging Strategies in Cancer Nanotechnolgy (2015) 39-43.

Sobczynski, D.J., Fish, M.B., Fromen, C.A., Carrasco-Teja, M., Coleman, R.M., Eniola-Adefeso, O., Drug Carrier Interactions in Blood. Ther Deliv 6:8 (2015) 916-934.

Petrosko, S.A., Fromen, C.A., Auyeung, E., DeSimone, J.M., Mirkin, C.A., Nanotechnology: an Enduring Bridge Between Engineering and Medicine. National Academy of Engineering, The Bridge (2013) 7-15.

Garcia A., Mack P., Williams, S., Fromen, C.A., Shen, T.W., Pillai, J., Kuehl, P., Napier, M.E., DeSimone, J.M., Maynor, B.W., Microfabricated Engineered Particle Systems for Respiratory Drug Delivery and Other Pharmaceutical Applications. Journal of Drug Delivery (2011) 941243.

Wang, Y., Merkel, T.J., Chen, K.; Fromen, C.A., Betts, D.E., DeSimone, J.M., Generation of a Library of Particles Having Controlled Sizes and Shapes via the Mechanical Elongation of Master Templates. Langmuir 27 (2011) 524-528.