Fromen Research Group

Engineering Particle-Lung Interactions

Welcome to the Fromen Research Group!  Our research is all about the lungs. We seek to advance understanding of the unique environment of the airways, from fluid dynamics to mucosal immunology. Armed with this foundation, we develop new therapeutics and analytical tools to treat a range of diseases specific to the lungs.

Recent Awards

Congratulations are in order for some amazing recent accomplishments!

First, congratulations to Kartik Bomb and the whole team for their recent publication in Biomaterials Science: Destructive fibrotic teamwork: how both microenvironment stiffness and profibrotic interleukin 13 impair alveolar macrophage phenotype and function! This work was the culmination of a collaborative research project with the April Kloxin group detailing macrophage responses in fibrotic microenvironments. Check out the paper here. Congratulations to the whole team and also to Prof Fromen; this article is featured in the Biomaterials Science Emerging Investigator Series collection for 2022! Check out the feature about her here.

Congratulations to Emily Kolewe for being recognized as a winner of a Rosalind Franklin Society Award in Science! Emily received this award based on her paper published last year in the Journal of Aerosol Medicine and Pulmonary Drug Delivery (Realizing Lobe-Specific Aerosol Targeting in a 3D-Printed In Vitro Lung Model). Check out the anthology of all of the Award winners including Emily which you can access here

Finally, congrats again to Emily Kolewe and the whole team for their recent publication in Computers in Biology and Medicine: Spatial aerosol deposition correlated to anatomic feature development in 6-year-old upper airway computational models! This work details differences in the anatomy of 6- year- old patients and how that influences inhaled drug delivery – it has been a fun collaboration with our computational collaborator, Prof. Yu Feng, and our clinical collaborator, Dr. Jenna Briddell. Congrats to the whole team and check out the paper here.

Summer 2022 Wrap up

It’s hard to believe that summer is coming to an end already… the Fromen lab has had a productive summer working with our awesome summer students and we are very proud of all they have accomplished!

Current Fromen lab undergraduates Saurav and Joaquina both completed their Summer Scholar’s virtual posters this past week.

Saurav worked with senior graduate student Emily Kolewe and his poster was titled “Studying interpatient variability by modeling aerosol particle deposition in pediatric airways”.

Joaquina worked at the interface of the 3D printing and call culture groups this summer, pioneering a new project area. Her poster was titled “Design of 3D pritned devices for pre-metered doses of nebulized drugs on cells cultured at the air-liquid interface”. A link to her poster video can be found here.

Congrats to both of you on your awesome work this summer and looking forward to more fun in the lab this upcoming year!

The Fromen lab was also lucky to host UD Rise Academy scholar Emmanuel Ortiz for an Experiential Learning opportunity in the group. Emmanuel is an incoming Chemical Engineering freshman who worked with Fromen lab graduate students as he prepared to start his first year of college at UD. With the lab, Emmanuel learned how to synthesize nanoparticles, honed his pipette skills, 3D printed his own part, and was able to gain first hand research experience. On Friday, he gave a presentation of his experience at the UD Rise Closing Ceremony.

Congrats Emmanuel on an awesome job this summer! We wish you lots of luck on starting your college career in a few short weeks and hope to see you back in the lab soon!

Finally, we have a big congratulations to incoming graduate student, Jodi Graf for her contributions this summer. She worked with graduate student Emma Sudduth synthesizing nanoparticles for on-going research in the group, while also pioneering two new project pilots to bring the group into new directions. 

Congrats on an awesome summer Jodi! We hope you had a great experience in the Fromen lab and wish you luck starting your PhD program this fall!

Last but not least in our summer round up, the Fromen lab gathered at the end of July for a summer lab retreat at Lums Pond. We worked together on crafting a shared lab values statement and brainstormed collaborative research projects together. (Check out our finalized statement on our Values page). We also played some goofy team building games and mastered walking across lines in synchronized fashion (which is harder than it looks!). Overall it was a great experience and a lot of fun was had by all!

Thanks team for your hard work this summer and looking forward to a great year ahead!

PhD #2!

Congratulations to the newly minted Dr. Zach Stillman, the Fromen lab’s second PhD graduate!!! Zach defended his thesis earlier this week, entitled “Evaluating the Properties and Uses of Metal-Organic Framework (MOF) and Polymer Nanoparticles for Applications in Vaccines and Pulmonary Drug Delivery”. Zach is on the job market for teaching positions and will be staying on with the Fromen lab for the rest of the summer. Many huge congratulations to Zach —  as an inaugural Fromie, he has done so much to shape the research and culture in the group and we are so thankful for your hard work! We are so proud of your accomplishments and can’t wait to see what you accomplish next!

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