VASCULAR PHYSIOLOGY LAB

ABOUT

The focus of the Vascular Physiology Lab is studying vascular function/dysfunction in healthy and diseased states, with particular emphasis on chronic kidney disease. Additionally, vascular responses to exercise and diet are studied. A variety of techniques are utilized to examine macro- and microvascular function as well as arterial stiffness in humans and animal models.

LAB PERSONNEL

Dave Edwards

Associate Professor

Kenneth Kirschner

Associate Scientist

Danielle Kirkman

Post Doctoral Fellow

Meghan Ramick

PhD candidate

Bryce Muth

PhD Student

Sophie Guderian

PhD Student

Joseph Stock

PhD Student

Liza Walker

PhD Student

CURRENT PROJECTS

Studies in Chronic Kidney Disease (CKD)
Exercise Training in CKD
The lab is currently investigating the effect of exercise training on vascular function in patients with CKD. We are also interested in understanding the mechanisms of exercise intolerance in CKD.

Mechanisms of impaired vascular function in CKD
The lab continues to study the mechanisms of impaired vascular function in CKD. We are also currently performing intervention studies to determine the effect of several with nutraceuticals on vascular function and exercise/physical performance in CKD.

Vascular Effects of Dietary Salt in Humans with Salt-Resistant BP
In collaboration with Dr. Bill Farquhar and his Cardiovascular Research Lab, we are exploring the effects of dietary salt on vascular function. Our hypothesis is that excess dietary salt adversely affects vascular function, independent of blood pressure.

Publications
  • Edwards DG, Farquhar WB. Vascular effects of dietary salt. Curr Opinion Nephrol Hypertens. 2015; 24:8-13.
  • Farquhar WB, Edwards DG, Jurkovitz CT, Weintraub WS. Dietary sodium and health: More than just blood pressure. J Am Coll Cardiol, 2015; 65:1042-1050.
  • Kuczmarski JM, Martens CR, Kim J, Lennon-Edwards SL, Edwards DG. Cardiac Function is Preserved Following 4-Weeks of Voluntary Wheel Running in a Rodent Model of Chronic Kidney Disease. J Appl Phys, 2014; 117:482-91.
  • Martens CR, Kuczmarski JM, Kim J, Guers JJ, Harris MB, Lennon-Edwards S, Edwards DG. Voluntary wheel running augments aortic L-arginine transport and endothelial function in rats with chronic kidney disease. Am J Physiol Renal Physiol, 2014; 307:418-26.
  • Lennon-Edwards SL, Ramick MG, Matthews EL, Brian MS, Farquhar WB, Edwards DG. Salt loading has more deleterious effect on flow-mediated dilation in salt-resistant males compared to females. Nutr Metab Cardiovasc Disease, 2014; 24:990-5.
  • DuPont JJ, Ramick MG, Farquhar WB, Townsend RR, Edwards DG. NADPH oxidase-derived superoxide contributes to impaired cutaneous microvascular function in chronic kidney disease. Am J Physiol Renal Physiol, 2014; 306:1499-1506.
  • Lennon-Edwards SL, Schellhardt T, Allman B, Edwards DG. Lower potassium Intake is associated with increased wave reflection in young healthy adults. Nutr J, 2014; 13:39. doi: 10.1186/1475-2891-13-39.
  • Ehrenthal DB, Goldstein ND, Rogers S, Townsend RR, Edwards DG. Arterial stiffness and wave reflection one year after a pregnancy complicated by hypertension. J Clin Hypertens, 2014; 16(10):695-9.
  • Kuczmarski JM, Martens CR, Lennon-Edwards SL, Edwards DG. Cardiac function and tolerance to ischemia-reperfusion injury chronic kidney disease. Nephrol Dial Transplant 2014, 29:1514-24.
  • Martens CR, Kuczmarski JM, Lennon-Edwards SL, Edwards DG. Impaired L-arginine uptake but not arginase contributes to endothelial dysfunction in rats with chronic kidney disease. J Cardiovasc Pharmacol 2014; 63:40-48.
  • Dupont JJ, Greaney JL, Wenner MM, Lennon-Edwards SL, Sanders PW, Farquhar WB, Edwards DG. High dietary sodium intake impairs endothelial-dependent dilation in healthy salt-resistant humans. J Hypertension 2013; 31:530-536.
Funding
  • 1 R01 HL113514, PI Edwards
  • 1 R01 HL104106, PIs Edwards and Farquhar
  • ACSM Foundation Research Grant, PI Ramick (doctoral student)