Overview

Located on the ground floor of the Ammon Pinizzotto Biopharmaceutical Innovation Center on the UD STAR Campus, this Neo 400 MHz NMR spectrometer was installed in 2022. It is equipped with a 5-mm Bruker iProbe and sample changer (SampleCase) for rapid turn-around NMR service. The iProbe has broadband channel that covers a frequency range from 109Ag to 31P and 19F and an optimized proton channel for 1H detection. This spectrometer, maintained by the NMR Center staff along with a Laboratory coordinator in APBio, is primarily used to support synthetic chemists, biochemists, and material scientists on the STAR campus.

This instrument accepts sample submission 24/7. The day-queue is reserved for short experiments such as 1D 1H, 13C, 19F, and 31P spectra. The night-queue is reserved for experiments that require more than one hour of instrument time such as 13C NMR for dilute samples and two-dimensional experiments (COSY, HMQC, HSQC, NOESY).

Instrument usage is recorded by the ICONNMR software package and further processed for billing using the laboratory management software iLab. Data acquired on the Neo 400 NMR spectrometer is automatically transferred to our NMR data server.

Training and Access

Level 1 training (offered in the NMR Center on main campus) covering magnet laboratory safety, sample preparation, sample loading/unloading, experiment selection, instrument automation, and data processing is available for all researchers at the University of Delaware and is a prerequisite for access to this instrument.

This instrument is primarily operated as a walk-up instrument that accepts sample submission 24/7 without reservations. The queue is based on the principle of first come first serve.  

Funding Information

  1. Discovery of Chemical Probes and Therapeutic Leads, NIH COBRE P20GM104316 (Principal Investigator: Joseph Fox) 2014-present
  2. University of Delaware MRSEC – Center for Hybrid, Active, and Responsive Materials (CHARM), NSF DMR2011824 (Principal Investigator: Thomas Epps, Co-Principal Investigators: Darrin Pochan, LaShanda Korley, Joshua Zide, April Kloxin) 2020-present