Motor network deficits in Parkinson’s disease
Motor impairment is the most relevant clinical feature in Parkinson’s disease (PD). Several projects in our lab are focused on neuroimaging of motor control in PD. In particular, we are using multi-modal magnetic resonance imaging (MRI) to examine the functional and structural brain changes underlying upper and lower limb dysfunction in PD.
Motor phenotypes in Parkinson’s disease
Distinct motor subtypes of Parkinson’s disease (PD) have been described based on clinical observation. Subtyping of patients is an important step for diagnosis, predicting the rate of progression, but also for determining inclusion in clinical trials and the development of individualized treatment plans based on motor symptoms. Current projects aim to develop non-invasive imaging markers that could objectively identify motor subtypes and contribute to a better understanding of the heterogeneity within the PD population.