1. I’m an off-campus user but is it fine if I want to drop off my sample or I want to visit the lab?
    • Yes. You may drop off your sample and follow the procedure for on-campus submissions. If you want to visit, email me with a few days lead time and we’ll see what we can arrange.
  2. How is billing done?
    • Internal samples are billed through iLab. External samples are billed per completed structure (not per sample).
  3. Where can I see a complete list of publications from results coming from this lab?
    • Publications that acknowledge the NIH for experiments performed on the D8 Venture diffractometer installed in 2020 are listed in NCBI. Prior work by Glenn P. A. Yap or Svilen Bobev can be searched with SciFinder.
  4. Should I just have structure of my final product(s)?
    • This depends on the focus of the manuscript. In any case, if the intermediate steps yield solid compounds and, especially if these are new compounds, it is useful to characterize them, I recommend to try to crystallize and obtain a structure. I have seen multiple times when the supposed intermediate compound in a multistep synthesis was not what was expected. More data is always better than less data!
  5. Can you determine the absolute chirality?
    • Yes, we can. If the compound has a heavy atom (i.e. atoms with elements heavier than sulfur) and the crystal is of average quality, we can usually determine absolute chirality directly by anomalous scattering. If the compound does not have a “heavy atom” but has a known chiral moiety that is retained during synthesis, then we can obtain the absolute configuration using relative configuration. Using Cu radiation even in the absence of heavy atoms, we have been able to obtain absolute configuration by anomalous scattering if the crystal quality allows collection of high resolution, high 2θ data.
  6. Can you tell me which industrial companies you work with?
    • No. NDA prohibits disclosure.
  7. What do I do if my question is not in this list?