Aberrant protein levels and activities contribute to numerous diseases, including cancers, cardiovascular disease, diabetes, and neurodegenerative diseases. No current therapy dynamically degrades excess protein(s) to treat diseases. The ability to tightly coordinate the levels of cellular proteins is critical for normal healthy cells to maintain homeostasis. We are developing new strategies that elicit dynamic and reversible protein degradation, which would overcome the challenges associated with targeting elevated levels of essential proteins.
Project 4. Dynamic modulation of cellular functions by controlled protein degradation (NSF)
