Molecular Physiology Seminar – Denis Guttridge

September 17, 2018 @ 1:00 pm – 2:00 pm
Location: STAR Atrium

Denis Guttridge, PhD
Medical University of South Carolina
Director of the Darby Children’s Research Institute
Associate Director of Translational Science in the Hollings Cancer Center

Title: Insights Into Cancer Cachexia and What Patient Data Can Tell Us
Abstract: Cachexia is a multifactorial condition tightly associated with chronic illnesses including, but not limited to cancer, chronic obstructive pulmonary disease, heart failure, chronic kidney disease, and rheumatoid arthritis. The syndrome 
is characterized by depletion of skeletal muscle and adipose tissues leading to pronounced weight loss that severely impacts patient morbidity and mortality. For cancer, estimates indicate that the prevalence of cachexia is 50-80%, which accounts for 20% deaths. However, in advanced cancers such as pancreatic cancer, which has a high incidence of cachexia, the mortality rate climbs to a staggering 80%. Muscle wasting in cachexia is thought to be driven by principally two mechanisms, one regulated by the ubiquitin proteasome pathway and the other by the autophagy system. Both are activated in skeletal myofibers by inflammatory cytokines that act through specific transcription factors to mediate the expression of specific components of the proteasome and autophagy systems. However, another mechanism controlling muscle turnover, proposed more recently by our laboratory, involves the failure of skeletal muscle cells to properly regenerate during a cachexia condition. This latter mechanism will be discussed in more details in the lecture. A second point in the lecture will be to discuss the currently used mouse models of cancer cachexia and whether they accurately recapitulate the features of cachexia in pancreatic cancer patients.

Seminar hosted by Dr. Matthew Hudson in association with KAAP

Biomechanics Seminar – Elena Grabowski

October 26, 2018 @ 10:00 am – 11:00 am
Location: STAR Atrium

Alena Grabowski, PhD
VA Research Healthcare Scientist
Assistant Professor at the University of Colorado Boulder

TitleThe effects of using running prostheses for athletes with transtibial amputations and implications for inclusion in Olympic track & field competition
Running-specific leg prostheses (RSPs) are made of carbon fiber, mimic the spring-like function of tendons, and allow elastic energy storage and return during level-ground steady-speed running; however, unlike biological legs, passive-elastic RSPs cannot generate mechanical power anew, vary stiffness, or allow ground clearance during leg swing. Previous research shows that athletes with transtibial amputations (TTAs) using RSPs have different biomechanics across running speeds (Grabowski et al. 2010), impaired starting block acceleration (Taboga et al. 2014) and slower curve-running performance (Taboga et al. 2016) compared to non-amputees. Dr. Grabowski will present a series of studies that assess the biomechanics, metabolic costs, and performance of athletes with unilateral and bilateral TTAs who use RSPs for running, sprinting, and jumping. Specifically, she will present scientific research regarding the effects of using RSPs and the implications of these findings for fairness in sport competition such as the Olympic Games.

Seminar hosted by Dr. Elisa Arch in association with KAAP

Concussion Seminar – Anthony Kontos

November 30, 2018 @ 12:00 pm – 1:00 pm
Location: STAR Atrium

Anthony Kontos, PhD
Director of Research for the UPMC Sports Medicine Concussion Program
Associate Professor in the Department of Orthopaedic Surgery
University of Pittsburgh

Title: One Size Does NOT Fit All: A Clinical Profiles Approach to Concussion Assessment and Treatment
Abstract: Concussion is a heterogenous injury for which a “one size fits all” approach is ineffective. The current presentation will discuss an emerging clinical profiles approach to assessing and treating this injury. Emphasis will be on the role of a comprehensive assessment including risk factors, symptoms, cognitive, vestibular, ocular, and psychological tools. Targeted and active treatments will also be discussed. The overarching theme of the presentation is that concussion is a treatable injury.

Seminar hosted by Dr. Thomas Kaminski in association with KAAP

Cardiovascular Seminar – Phil Ainslie

February 8, 2019

Innovative Technology Seminar – Adam Persky

March 2019

Motor Control Seminar – David Vaillancourt

April 2019