Publications

2019

D’Ambrosio EA*, Drake WR*, Mashayekh S*, Ukaegbu OI, Brown AR, Grimes CL. Modulation of the Nod-like receptors NOD1 and NOD2: A Chemist’s Perspective. Bioorganic medicinal chemistry letters. (2019). in press

Lazor KM, Zhou J, DeMeester KE, D’Ambrosio EA, Grimes CL. Synthesis and application of methyl N,O-hydroxylamine muramyl peptides. ChemBioChem. (2019). in press

2018

McDonald ND, DeMeester KE, Lewis AL, Grimes CL, Boyed EF. Structural and functional characterization of a modified legionaminic acid involved in glycosylation of a bacterial lipopolysaccharide. Journal of Biological Chemistry.(2018). 293(49), 19113–19126

PV Chang, CL Grimes. Designer Dendrons To Dissect Innate Immune Signaling. ACS Central Science (2018) 4 (8),  948–949

DeMeester KE, Liang H, Jensen MR, Jones ZS, D’Ambrosio EA, Scinto SL, Zhou J, Grimes CL. Synthesis of functionalized N-acetyl muramic acids to probe bacterial cell wall recycling and biosynthesis. JACS. (2018) 140 (30), 9458–9465

Liang H,  Zhou G, Ge Y, D’Ambrosio EA, Eidem TMBlanchard C, Shehatou C, Chatare VKDunman PMValentine AMVoelz VAGrimes CL, Andrade RB. Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus. Bioorganic and Medicinal Chemistry (2018) 26 (12), 3453-3460

Drake WR, Hou CW, Zachara NE, Grimes CL.New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT. Journal of bioenergetics and biomembranes. (2018) 50 (3), 231-240

Burch JM, Mashayekh S, Wykoff DD, Grimes CL. Bacterial Derived Carbohydrates Bind Cyr1 and Trigger Hyphal growth in Candida albicans. ACS Infectous Diseases. (2018) 4,  53-58

2017

Wang Y, Lazor KM, DeMeester KE, Liang H, Heiss TK, Grimes CL. Postsynthetic Modification of Bacterial Peptidoglycan Using Bioorthogonal N-Acetylcysteamine Analogs and Peptidoglycan O-Acetyltransferase B. JACS. (2017) 139, 13596-13599.

Schaefer AK, Wastyk HC, Mohanan V, Hou CW, Lauro ML, Melnyk JE, Burch JM, Grimes CL. Crohn’s Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70. Biochemistry. (2017), 56, 4445-4448.

Schaefer AK*, Melnyk JE*, Baksh MM, Lazor KM, Finn MG, Grimes CL. Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2. ACS Chemical Biology. (2017) 12, 2216-2224.

Liang H*, DeMeester KE*, Hou CW, Parent MA, Caplan JL, Grimes CL. Metabolic labeling of the carbohydrate core in bacterial peptidoglycan and its applications. Nature Communications. (2017) 8, 15015.

Lauro ML, D’Ambrosio EA, Bahnson BJ, Grimes CL. Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2. ACS Infectious Diseases. (2017) 3, 264-270.

2016

Hou, C-W, Lauro, M.L., Grimes, C.L., “Redefining the Defensive Line: Critical Components of the Innate Immune System”, ACS Infectious Diseases. (2016), 2, 746.

Lauro, M., Burch, J., Grimes, C.L, “The effect of Nod2 on the microbiota in Crohn’s disease” Curr Opin Biotechnol. (2016), 40, 97.

2015

Hou, C-W, Mohanan, V, Zachara, N.E, Grimes, C.L., “Identification and biological consequences of the OGlcNAc modification of the human innate immune receptor, Nod2” Glycobiology, (2016), 26, 13.

Grimes, C.L, White, H.B, “Passing the Baton: Passing the Baton: Mentoring for Adoption of Active-learning Pedagogies by Research-active Junior Faculty.” Biochem. Molec. Biol. Educ., (2015), 43, 345.

Melnyk, J.E., Mohanan, V., Schaefer, A.K., Hou, C-H., Grimes, C.L., Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2, JACS, (2015)137, 6987.

2014

Mohanan, V., Grimes, C.L., The Molecular Chaperone HSP70 binds to and stabilizes NOD2, an important protein in Crohn’s Disease, J. Biol. Chem, (2014), 289, 18987.

2012

Grimes, C.L.*, Ariyananda, L.D., Melnyk, J.E., O’Shea, E.K, The Innate Immune Protein, Nod2, Binds directly to MDP, a bacterial cell wall fragment. JACS, (2012) 134, 13535. (CLG is corresponding author)

Leimkuhler Grimes Post-Doctoral and Graduate Publications:

Grimes, C.L., Podolsky, D.K., O’Shea, E.K., Synthesis of Biologically Active Biotinylated Muramyl Dipeptides, Bioorg Med Chem Lett., 2010. 20(20): p. 6061-3.  

Hu, Y., Al-Mestarihi, A., Grimes, C.L., Kahne, D., and Bachmann, B.O., A unifying nitrososynthase involved in nitrosugar biosynthesis. JACS, 2008. 130(47): p. 15756-7. 

Leimkuhler, C., Fridman, M., Lupoli, T., Walker, S., Walsh, C.T., and Kahne, D., Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. JACS, 2007. 129(34): p. 10546-50.

Howard-Jones, A.R., Kruger, R.G., Lu, W., Tao, J., Leimkuhler, C., Kahne, D., and Walsh, C.T., Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. JACS, 2007. 129(33): p. 10082-3.

Adachi, M., Zhang, Y., Leimkuhler, C., Sun, B., LaTour, J.V., and Kahne, D.E., Degradation and reconstruction of moenomycin A and derivatives: dissecting the function of the isoprenoid chain. JACS, 2006. 128(43): p. 14012-3.

Lu, W., Leimkuhler, C., Gatto, G.J., Jr., Kruger, R.G., Oberthur, M., Kahne, D., and Walsh, C.T., AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A. Chem Biol, 2005. 12(5): p. 527-34.

Leimkuhler, C., Chen, L., Barrett, D., Panzone, G., Sun, B., Falcone, B., Oberthur, M., Donadio, S., Walker, S., and Kahne, D., Differential inhibition of Staphylococcus aureus PBP2 by glycopeptide antibiotics. JACS, 2005. 127(10): p. 3250-1.

Kahne, D., Leimkuhler, C., Lu, W., and Walsh, C., Glycopeptide and lipoglycopeptide antibiotics. Chem Rev, 2005. 105(2): p. 425-48.

Leimkuhler, C., Chen, Z., Kruger, R.G., Oberthur, M., Lu, W., Walsh, C.T., and Kahne, D., Glycosylation of glycopeptides:  a comparision of chemoenzymatic and chemical methods. Tetrahedron:  Asymmetry, 2005. 16(2): p. 599-603.

Yuan, Y., Chung, H.S., Leimkuhler, C., Walsh, C.T., Kahne, D., and Walker, S., In Vitro Reconstitution of EryCIII Activity for the Preparation of Unnatural Macrolides. JACS, 2005. 127(41): p. 14128-14129. 

Barrett, D., Leimkuhler, C., Chen, L., Walker, D., Kahne, D., and Walker, S., Kinetic Characterization of the Glycosyltransferase Module of Staphylococcus aureus PBP2. J Bacteriol, 2005. 187(6): p. 2215-7.

Oberthur, M., Leimkuhler, C., Kruger, R.G., Lu, W., Walsh, C.T., and Kahne, D., A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases. JACS, 2005. 127(30): p. 10747-52.

Lu, W., Leimkuhler, C., Oberthur, M., Kahne, D., and Walsh, C.T., AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A. Biochemistry, 2004. 43(15): p. 4548-58.

Lu, W., Oberthur, M., Leimkuhler, C., Tao, J., Kahne, D., and Walsh, C.T., Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin. Proc Natl Acad Sci U S A, 2004. 101(13): p. 4390-5. 

Oberthur, M., Leimkuhler, C., and Kahne, D., A practical method for the stereoselective generation of beta-2-deoxy glycosyl phosphates. Org Lett, 2004. 6(17): p. 2873-6.

 

Leimkuhler Grimes Undergraduate Publications:

Belardi, J. K., Curtis, L. A., Clareen, S. S., Shimp, H. L., Leimkuhler, C. E., Simonowicz, N. L. and Casillas, E. “A Nazarov Approach to 4-Benzoyloxymethyl-cyclopent-2-enone, a Precursor to the Helminthosporols.” Synth Comm 2005, 35, 1633-1640.

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