Kyle D. Meadows

PhD Student in Biomedical Engineering
University of Delaware
meadowkd at udel.edu

 

Education
BSE in Biomedical Engineering
Duke University, 2015

 

Magnetic Resonance Imaging of Fibrous Soft Tissue Degeneration

My research focuses on using magnetic resonance imaging (MRI) to track degeneration of fibrous soft tissues in the spine and knee. Specifically, I can explore changes in structure, biochemical content, and load transfer before and after injury. Further I can relate these changes to post-dissection measures to better explain the progression of degeneration and its ramifications.

MR images of lumbar spine in flexed (left) and extended (right) postures

Quantitative MRI of healthy and torn porcine meniscus

Peer Reviewed Publications

  1. Kyle D. Meadows, Curtis L. Johnson, John M. Peloquin, Richard G. Spencer, Edward J. Vresilovic, Dawn M. Elliott. “Impact of Pulse Sequence, Analysis Method, and Signal to Noise Ratio on the Accuracy of Intervertebral Disc T2 Measurement,” JOR Spine. 2020;e1102. https://doi.org/10.1002/jsp2.1102.
  2. Sonia Bansal, Liane M. Miller, Jay M. Patel, Kyle D. Meadows, Michael R. Eby, Kamiel S. Saleh, Anthony R. Martin, Brendan D. Stoeckl, Michael Hast, Dawn M. Elliott, Miltiadis H. Zgonis, Robert L. Mauck. “Unloading of the Medial Meniscus Results in Cartilage Degeneration and Meniscus Remodeling in a Large Animal Model,” J Orthop Res. 2020;10.1002/jor.24694. https://doi.org/10.1002/jor.24694
  3. Babak N. Safa, Kyle D. Meadows, Spencer E. Szczesny, Dawn M. Elliott. “Exposure to Buffer Solution Alters Tendon Hydration and Mechanics,” Journal of Biomechanics 61 (2017) 18-25. https://doi.org/10.1016/j.jbiomech.2017.06.045

Conference Proceedings

  1. Meadows, KD; Bansal S; Peloquin JM; Miller LM; Patel JM; Saleh KS; Hast MW; Zgonis MH; Mauck RL; Elliott DM. “MRI of Meniscus and Cartilage Changes after Meniscus Injury in a Large Animal Model,”: Biomedical Engineering Society Annual Meeting (BMES), Philadelphia, PA, Oct 2019. (Oral presentation)
  2. Meadows, KD; Bansal S; Peloquin JM; Miller LM; Patel JM; Saleh KS; Hast MW; Zgonis MH; Mauck RL; Elliott DM. “Non-Invasive MRI Assessment of Meniscus and Cartilage Changes in a Large Animal Model of Meniscus Injury,”: Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), Seven Springs, PA, Jun 2019. (Oral presentation)
  3. Meadows, KD; Bansal S; Peloquin JM; Miller LM; Patel JM; Saleh KS; Hast MW; Zgonis MH; Mauck RL; Elliott DM. “Non-Invasive MRI Assessment of Meniscus and Cartilage Changes in a Large Animal Model of Meniscus Injury,”: Center for Biomechanical Engineering Research Symposium (CBER), Newark, DE, Apr 2019. (Oral presentation)
  4. Meadows, KD; Peloquin JM; Johnson CJ; Spencer R; Elliott DM. “Accuracy of Quantitative MRI T2 Measurements of the Intervertebral Disc with Noise and a Noise Floor,”: Philadelphia Spine Research Society Annual Meeting (PSRS), Philadelphia, PA, Nov 2018. (Oral presentation)
  5. Peloquin JM; Meadows, KD; Vresilovic EJ; Elliott DM. “In Vivo Measurement of 3D Disc Strain and Degenerative Variation Using MRI,”: International Society for the Study of the Lumbar Spine Annual Meeting (ISSLS), Banff, Canada, May 2018. (Oral presentation)
  6. Meadows, KD; Peloquin JM; Vresilovic EJ; Elliott DM. “In Vivo MRI Quantification of Human Disc Compression and Flexion/Extension,”: Orthopaedic Research Society Annual Meeting (ORS), New Orleans, LA, Mar 2018. (Oral presentation in Spotlight Session)
  7. Peloquin JM; Meadows, KD; Vresilovic EJ; Elliott DM. “In Vivo Human Intervertebral Disc Strain From 3D MRI and its Degeneration-dependent Variation,”: ORS, New Orleans, LA, Mar 2018. (Oral presentation)
  8. Meadows, KD; Peloquin JM; Vresilovic EJ; Elliott DM. “In Vivo MRI Quantification of Human Disc Compression and Flexion/Extension,”: Philadelphia Spine Research Society Annual Meeting (PSRS), Lake Harmony, PA, Oct 2017. (Oral presentation)
  9. Meadows, KD; Peloquin JM; Vresilovic EJ; Elliott DM. “MRI Quantification of In Vivo Human Disc Mechanical Function During Diurnal Compression and Induced Flexion/Extension,”: Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), Tucson, AZ, Jun 2017. (Oral presentation)
  10. Meadows, KD; Claeson AA; DeLucca JF; Peloquin JM; Vresilovic EJ; Elliott DM. “Human Cartilaginous Endplate Discontinuities: FLASH MRI for Potential Clinical Diagnostics,”: International Society for the Study of the Lumbar Spine Annual Meeting (ISSLS), Athens, Greece, May/Jun 2017. (Poster presentation)
  11. Meadows, KD; Peloquin JM; Vresilovic EJ; Elliott DM. “MRI Quantification of In Vivo Human Disc Mechanical Function During Diurnal Compression and Induced Flexion/Extension,”: Center for Biomechanical Engineering Research Symposium (CBER), Newark, DE, Mar 2017. (Poster presentation)
  12. Meadows, KD; Claeson AA; DeLucca JF; Vresilovic EJ; Elliott DM. “FLASH MRI for Potential Clinical Diagnostics of Cartilaginous Endplate Discontinuities,”: PSRS, Philadelphia, PA, Nov 2016. (Oral presentation)
  13. Safa, BN; Meadows, KD; Szczesny, SE; Elliott, DM. “Long-term Exposure to Buffer Solution Alters Tendon Structure and Mechanics-Implications for Fatigue Studies.” SB3C, National Harbor, MD, June 2016 (M.Sc. level poster competition 3rd place)