Vasodilatory Function in Young and Postmenopausal Women
Purpose:
The purpose of this study is to learn more about blood vessel function and the ability of the blood vessels to dilate in women. With advancing age, blood vessel function declines and cardiovascular disease risk increases. There are several substances made by the body that control blood vessel function. We previously have shown one substance, endothelin-1 (ET-1), to play an important role in contributing to decreased blood vessel function in postmenopausal women. The aims of this study are to examine how ET-1 interacts with other substances (angiotensin II and norepinephrine) that can reduce the ability of the blood vessel to dilate. To do this we will use a technique called microdialysis.
Inclusion:
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Exclusion:
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Your Participation:
Full participation in this study will require 3 visits. Each visit may last from one to five hours. The first visit will take place at the Nurse Managed Primary Care Center. The second and third visits will take place in our lab. Both of these facilities are located at 540 S. College Avenue (STAR Health Sciences Complex) in Newark, DE.
Your participation in this research study is entirely voluntary and you have the right to stop at any time.
Compensation:
You will receive compensation for full completion of the study. Compensation will be described during the consent process.