Elizabeth L. Isaac, Lauren N. Tumbelty, and William J. Chain. Transformation of a N,N-Dimethylaniline N-oxide into a Tetrahydroquinoline Scaffold via a Formal Polonovski-Povarov Reaction

Ali Amiri Naeini, Alexandre A. Ziegelmeier, and William J. Chain. Recent Developments with Icetexane Natural Products

Hatch, C.E., Martin, M.I., Gilmartin, P.H., Xiong, L., Beam, D.J., Yap, G.P.A., Von Bargen, M.J., Rosenthal, J., Chain, W.J. Electrochemically Mediated Oxidation of Sensitive Propargylic Benzylic Alcohols

Zhenhua Wu, Jean-Simon Suppo, Sarka Tumova, Jonathan Strope, Fernando Bravo, Melody Moy, Ethan S. Weinstein, Cody J. Peer, William D. Figg, William J. Chain, Antonio M. Echavarren, David J. Beech, and John A. Beutler. Bridgehead Modifications of Englerin A Reduce TRPC4 Activity and Intravenous Toxicity but not Cell Growth Inhibition. ACS Med. Chem. Lett. 2020, 11 (9), 1711-1716. 

Hayley Reed, Tyler R. Paul, and William J. Chain. Synthesis of Halogenated Anilines by Treatment of N,N‑Dialkylaniline N‑Oxides with Thionyl Halides. J. Org. Chem. 2018, 83 (18), 11359-11368. 

Timothy S. Bush, Glenn P. A. Yap, and William J. Chain. Transformation of N,N‑Dimethylaniline N‑Oxides into Diverse Tetrahydroquinoline Scaffolds via Formal Povarov Reactions. Org. Lett. 2018, 20 (17), 5406-5409. 

Daniel J. Moon; Mohammad Al-Amin; Robert S. Lewis; Kimberly M. Arnold; Glenn P. A. Yap; Jennifer Sims-Mourtada; William J. Chain; A Strategy Toward Icetexane Natural Products.. J. Org. Chem. 10.1002/ejoc.20180070. 

Zhenhua Wu; Senzhi Zhao; David M. Fash; Zhenwu Li; William J. Chain; John A. Beutler. Englerins: A Comprehensive Review. J. Nat. Prod. 2017, 80 (3), 771-781. 

Fash, D. M.; Peer, C. J.; Li, Z.; Talisman, I. J; Hayavi, S.; Sulzmaier, F. J.; Ramos, J. W.; Sourbier, C.; Neckers, L.; Figg, W. D.; Beutler, J. A.; Chain, W. J. Synthesis of a Stable and Orally Bioavailable Englerin Analogue.  Bioorg. Med. Chem. Lett. 2016, 26, 2641–2644.

Lewis, R. S.; Garza, C. J.; Dang, A. T.; Pedro, T.-K. A.; Chain, W. J. Michael Additions of Highly Basic Enolates to ortho-Quinone Methides. Org. Lett. 2015, 17, 2278–2281.

Lewis, R. S.; Nakashige, M. L.; Chain, W. J.  Transformation of N,N-Dimethylaniline-N-oxides into N-methylindolines by a Tandem Polonovski-Mannich Reaction. Tetrahedron Lett. 2015, 56, 3531–3533.

Lewis, R. S.; Wisthoff, M. F.; Grissmerson, J.; Chain, W. J. Metal-Free Functionalization of N,N-Dialkylanilines via Temporary Oxidation to N,N-Dialkylaniline-N-Oxides and Group Transfer.  Org. Lett.  2014,16, 3832–3835.

Chain, W. J.  The Upside of Panic:  Developing a Synthesis of Englerin A.  Invited Contribution to Strategies and Tactics in Organic Synthesis, 2013 (Harmata, M., Ed.), Volume 9, pp. 79–104.

Sulzmaier, F. J.; Li, Z.; Nakashige, M. L.; Fash, D. M.; Chain, W. J.; Ramos, J. W.  Englerin A selectively induces necrosis in human renal cancer cells.  PLoS ONE. 2012, 7, e48032.  

Chen, M.-T.; Vicic, D. A.; Chain, W. J.; Turner, M. L.; Navarro, O. Inhibited Catalyst Activation in (N-Heterocyclic carbene)PdCl2(diethylamine) Complexes by Intramolecular Hydrogen Bonding.  Organometallics. 2011, 30, 6770–6773.

Chain, W. J. Synthetic Strategies Toward the Guaiane Sesquiterpene Englerin A. Synlett. 2011, 2605–2608.

\Li, Z.; Nakashige, M.; Chain, W. J. A Brief Synthesis of (–)-Englerin A.  J. Am. Chem. Soc. 2011, 133, 6553–6556.

Dubinina, G. G.; Chain, W. J.  Reactions of Azepinones With Electrophiles.  Tetrahedron Lett.  2011, 52, 939–942.

Dubinina, G. G.; Yoshida, W. Y.; Chain, W. J.  On the Preparation of Azepinones.  Tetrahedron Lett. 2010, 51, 5325–5327.

Publications from Supervised Career

Kummer, D. A.; Chain, W. J.; Morales, M. R.; Quiroga, O.; Myers, A. G.  Stereocontrolled Alkylative Construction of Quaternary Carbon Centers.  J. Am. Chem. Soc. 2008, 130, 13231–13233.

Chain, W. J.; Myers, A. G.  A Convenient, NMR-Based Method for the Analysis of Diastereomeric Mixtures of Pseudoephedrine Amides.  Org. Lett. 2007, 9, 355–357.

Harki, D. A.; Graci, J. D.; Galarraga, J. E.; Chain, W. J.; Cameron, C. E.; Peterson, B. R.  Synthesis and Antiviral Activity of 5-Substituted Cytidine Analogues:  Identification of a Potent Inhibitor of Viral RNA-Dependent RNA Polymerases.  J. Med. Chem. 2006, 49, 6166–6169.