Modeling drug delivery in the lymph node
Dr. Ryan Zurakowski
Associate Professor, Department of Biomedical Engineering, University of Delaware, DE
In this talk I will discuss the history of my group’s involvement in HIV cure research, from our early investigations into optimal treatment scheduling, which led to a collaboration with the IRSI-CAIXA institute in Barcelona. This collaboration resulted in the discovery of evidence of cryptic viremia in apparently suppressed patients, and further collaborations with the Ragon Institute at Harvard/MGH, the Doherty Institute at the University of Melbourne, and UCSF. Insights from these led us to realize the importance of the 3D structure of the lymph node in cryptic HIV viremia, which has led to our current ongoing collaboration with the Gleghorn Lab at UD, interrogating the mechanisms of drug delivery and exclusion in the lymph node.
Dr. Zurakowski received a Ph.D. in Electrical and Computer Engineering from University of California at Santa Barbara. He is currently an Associate Professor in the Department of Biomedical Engineering at UD. He is also a Faculty Fellow at the Delaware Biotechnology Institute. Dr. Zurakowski is a Program Faculty of the new NIH T32 Predoctoral Training Grant in Computational Biology, Bioinformatics, and Biomedical Data Science (CBB). He will serve among the faculty mentors for the first cohort of T32 Fellows funded by this prestigious award (Grant Number T32GM142603) starting Fall 2022. Dr. Zurakowski’s areas of research include mathematical modeling, cryptic HIV replication, information-optimal experiment design and censored-data estimation. More specifically, his group develops mathematical models of diseases. The models developed made a number of significant contributions to the understanding of HIV disease.
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