chemcail-logoOur research program is highly interdisciplinary, encompassing chemistry, biology and medicine. Our current efforts are directed toward understanding the chemistry and biology of protein post-translational modification (PTM) by ubiquitin (Ub) and eukaryotic DNA damage tolerance. We focus on the function, structure and regulation of enzymes and protein complexes involved in reversible protein ubiquitylation and DNA damage tolerance The current projects include developing chemical approaches for protein ubiquitylation; synthesis of ubiquitin-based probes, the regulation and inhibition of deubiquitinase (DUB) complex;  and molecular mechanism of DNA damage tolerance. We investigate these problems at a molecular level by employing a broad spectrum of chemical, structural, and biological approaches.

We look for talented graduate students and postdoctoral fellows with interests and expertise in biochemistry, organic synthesis, structural biology, and molecular & cell biology. Please contact us at zzhuang@udel.edu or (302) 831-8940 if you are interested in joining our research group.