New Method for Quat Center Formation

Congratulations to Kelsey Cobb, Javon Rabb-Lynch, Megan Hoerrner, Alex Manders, and Qi Zhou on their recent development of a stereospecific Suzuki–Miyaura cross-coupling of allylic pivalates to set all-carbon quaternary stereocenters (http://pubs.acs.org/doi/full/10.1021/acs.orglett.7b02063)! This reaction is enabled by a simple nickel/BISBI catalyst system, and enables efficient formation of allylic products with internal alkenes.

The Latest from our Lab: Cross Couplings via C–N Bond Cleavage

Congratulations to Corey Basch, Jennie Liao, Jianyu Xu, and Jake Piane for their recent discovery of a new nickel-catalyzed cross coupling of alkyl pyridinium salts (http://pubs.acs.org/doi/abs/10.1021/jacs.7b02389)! When coupled with efficient formation of pyridinium salts from primary amines, this reaction enables the use of alkyl amines to alkyl arenes. It is the first cross coupling of an alkyl amine derivative with unactivated alkyl groups.

Congratulations, Dr. Cobb!

Congratulations to Dr. Kelsey Cobb on the successful defense of your thesis! Kelsey’s research focused on new nickel-catalyzed cross couplings of amine and alcohol derivatives to prepare highly enantioenriched products. We wish you all the best in your next position at Solenis!

Congratulations, Dr. Liu!

Congratulations to Dr. Jixin Liu on the successful defense of your thesis! In our group, Jixin pioneered the development of diastereoselective and enantioselective alkynylations of oxocarbenium and iminium ion intermediates. We wish you all the best in your next position at Adesis!