Our goal is to characterize the biological basis of variation in quantitative traits as it relates to poultry breeding and genetics programs. Our research is currently focused on modern broiler chickens. We study the genetic basis of differences in traits of agricultural importance, including emerging muscle disorders in broiler chickens. Using diverse multidisciplinary approaches, we aim to track the flow of biological information from DNA to RNA, its translation to protein, and eventually its impact on metabolism at cellular and molecular levels. Genome-wide association studies (GWAS), next-generation DNA- and RNA-sequencing, detecting genomic signatures of positive selection, and finding genes with allele specific expression (ASE) are among the major approaches that we are currently using to find genes underlying variation in important traits.